6DWO
Crystal structure of alpha-1-2-mannosidase from Enterococcus faecalis V583
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000224 | molecular_function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| A | 0006516 | biological_process | glycoprotein catabolic process |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000224 | molecular_function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| B | 0006516 | biological_process | glycoprotein catabolic process |
| B | 0030246 | molecular_function | carbohydrate binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000224 | molecular_function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| C | 0006516 | biological_process | glycoprotein catabolic process |
| C | 0030246 | molecular_function | carbohydrate binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000224 | molecular_function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| D | 0006516 | biological_process | glycoprotein catabolic process |
| D | 0030246 | molecular_function | carbohydrate binding |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 801 |
| Chain | Residue |
| A | ALA13 |
| A | GLN15 |
| A | HIS50 |
| A | GLU52 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 802 |
| Chain | Residue |
| A | HOH952 |
| A | HOH1052 |
| A | ASN562 |
| A | GLN563 |
| A | ASP604 |
| A | GOL807 |
| A | GOL808 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue K A 803 |
| Chain | Residue |
| A | ASN20 |
| A | THR597 |
| A | TYR599 |
| A | HOH923 |
| A | HOH1172 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 804 |
| Chain | Residue |
| A | ARG97 |
| A | LEU113 |
| A | ASP554 |
| A | HOH1068 |
| A | HOH1212 |
| A | HOH1263 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 805 |
| Chain | Residue |
| A | THR12 |
| A | ASN14 |
| A | CYS23 |
| A | LEU24 |
| A | TRP47 |
| A | PHE49 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 806 |
| Chain | Residue |
| A | ARG114 |
| A | TYR115 |
| A | ASN536 |
| A | VAL537 |
| A | HOH1225 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 807 |
| Chain | Residue |
| A | TRP68 |
| A | MET359 |
| A | GLU494 |
| A | HIS545 |
| A | GLU546 |
| A | ASP602 |
| A | ASP604 |
| A | CA802 |
| A | GOL808 |
| A | HOH1052 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 808 |
| Chain | Residue |
| A | TRP312 |
| A | ASP313 |
| A | TRP350 |
| A | MET359 |
| A | GLU494 |
| A | ASN562 |
| A | ASP604 |
| A | CA802 |
| A | GOL807 |
| A | HOH1088 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 809 |
| Chain | Residue |
| A | GLY45 |
| A | SER46 |
| A | ARG60 |
| A | GLN64 |
| A | ASP71 |
| A | HOH959 |
| A | HOH1227 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 1001 |
| Chain | Residue |
| B | ASN562 |
| B | GLN563 |
| B | ASP604 |
| B | GOL1006 |
| B | GOL1007 |
| B | HOH1166 |
| B | HOH1429 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue K B 1002 |
| Chain | Residue |
| B | ASN20 |
| B | THR597 |
| B | TYR599 |
| B | HOH1202 |
| B | HOH1326 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 1003 |
| Chain | Residue |
| B | ASN109 |
| B | THR118 |
| B | THR131 |
| B | ASP133 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue ACT B 1004 |
| Chain | Residue |
| A | PRO655 |
| B | ARG97 |
| B | ASP554 |
| B | HOH1229 |
| B | HOH1368 |
| B | HOH1487 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 1005 |
| Chain | Residue |
| B | ARG114 |
| B | TYR115 |
| B | ASN536 |
| B | VAL537 |
| B | HOH1125 |
| site_id | AD6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 1006 |
| Chain | Residue |
| B | TRP68 |
| B | GLU494 |
| B | HIS545 |
| B | GLU546 |
| B | ASP602 |
| B | ASP604 |
| B | CA1001 |
| B | GOL1007 |
| B | HOH1429 |
| site_id | AD7 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 1007 |
| Chain | Residue |
| B | MET359 |
| B | GLU494 |
| B | ASN562 |
| B | GLN563 |
| B | ASP604 |
| B | CA1001 |
| B | GOL1006 |
| B | TRP312 |
| B | ASP313 |
| B | TRP350 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 1008 |
| Chain | Residue |
| B | ALA13 |
| B | ASN14 |
| B | GLN15 |
| B | HIS50 |
| B | GLU52 |
| B | HOH1230 |
| B | HOH1411 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 1009 |
| Chain | Residue |
| B | GLY45 |
| B | SER46 |
| B | TRP48 |
| B | ARG60 |
| B | GLN64 |
| B | GLY70 |
| B | ASP71 |
| B | HIS74 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 1010 |
| Chain | Residue |
| B | LYS162 |
| B | ASP173 |
| B | SER175 |
| B | TYR177 |
| B | HOH1258 |
| B | HOH1282 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 B 1011 |
| Chain | Residue |
| B | SER17 |
| B | THR41 |
| B | THR55 |
| B | PHE90 |
| B | GLN93 |
| B | HOH1107 |
| B | HOH1242 |
| B | HOH1389 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 1001 |
| Chain | Residue |
| C | ASN562 |
| C | GLN563 |
| C | ASP604 |
| C | GOL1005 |
| C | GOL1006 |
| C | HOH1147 |
| C | HOH1343 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue K C 1002 |
| Chain | Residue |
| C | ASN20 |
| C | THR597 |
| C | TYR599 |
| C | HOH1169 |
| C | HOH1297 |
| C | HOH1449 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue ACT C 1003 |
| Chain | Residue |
| C | THR12 |
| C | ASN14 |
| C | CYS23 |
| C | TRP47 |
| C | PHE49 |
| C | HOH1363 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT C 1004 |
| Chain | Residue |
| C | ARG97 |
| C | LEU113 |
| C | ASP554 |
| C | HOH1246 |
| C | HOH1272 |
| site_id | AE7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 1005 |
| Chain | Residue |
| C | TRP68 |
| C | GLU494 |
| C | HIS545 |
| C | GLU546 |
| C | ASP602 |
| C | ASP604 |
| C | CA1001 |
| C | GOL1006 |
| C | HOH1343 |
| site_id | AE8 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 1006 |
| Chain | Residue |
| C | ASP313 |
| C | TRP350 |
| C | MET359 |
| C | GLU494 |
| C | ASN562 |
| C | ASP604 |
| C | CA1001 |
| C | GOL1005 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 1007 |
| Chain | Residue |
| C | SER46 |
| C | TRP48 |
| C | ARG60 |
| C | GLN64 |
| C | ASP71 |
| C | HIS74 |
| C | HOH1382 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 1008 |
| Chain | Residue |
| C | ALA13 |
| C | ASN14 |
| C | GLN15 |
| C | HIS50 |
| C | GLU52 |
| C | HOH1151 |
| C | HOH1417 |
| site_id | AF2 |
| Number of Residues | 7 |
| Details | binding site for residue CA D 1001 |
| Chain | Residue |
| D | ASN562 |
| D | GLN563 |
| D | ASP604 |
| D | GOL1006 |
| D | GOL1007 |
| D | HOH1149 |
| D | HOH1370 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue K D 1002 |
| Chain | Residue |
| D | ASN20 |
| D | THR597 |
| D | TYR599 |
| D | HOH1108 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue ACT D 1003 |
| Chain | Residue |
| D | ASN14 |
| D | CYS23 |
| D | LEU24 |
| D | TRP47 |
| D | PHE49 |
| D | HOH1386 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue ACT D 1004 |
| Chain | Residue |
| C | PRO655 |
| D | ARG97 |
| D | LEU113 |
| D | ASP554 |
| D | HOH1189 |
| D | HOH1214 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue ACT D 1005 |
| Chain | Residue |
| D | ARG114 |
| D | TYR115 |
| D | ASN536 |
| D | VAL537 |
| site_id | AF7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 1006 |
| Chain | Residue |
| D | TRP68 |
| D | GLU494 |
| D | HIS545 |
| D | GLU546 |
| D | ASP602 |
| D | ASP604 |
| D | CA1001 |
| D | GOL1007 |
| D | HOH1370 |
| site_id | AF8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 1007 |
| Chain | Residue |
| D | TRP312 |
| D | ASP313 |
| D | TRP350 |
| D | MET359 |
| D | GLU494 |
| D | ASN562 |
| D | ASP604 |
| D | CA1001 |
| D | GOL1006 |
| site_id | AF9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 1008 |
| Chain | Residue |
| D | ALA13 |
| D | ASN14 |
| D | GLN15 |
| D | HIS50 |
| D | GLU52 |
| D | HOH1228 |
| site_id | AG1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 1009 |
| Chain | Residue |
| D | GLY45 |
| D | SER46 |
| D | ARG60 |
| D | GLN64 |
| D | ASP71 |
