6DW0

Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (Whole map)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0004890	molecular_function	GABA-A receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0004890	molecular_function	GABA-A receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0004890	molecular_function	GABA-A receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0004890	molecular_function	GABA-A receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006821	biological_process	chloride transport
D	0007214	biological_process	gamma-aminobutyric acid signaling pathway
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0004890	molecular_function	GABA-A receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC

Chain	Residue	Details
E	CYS136-CYS150
D	CYS151-CYS165
C	CYS138-CYS152

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	438
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
E	HIS1-TYR220
B	HIS1-TYR220
C	TYR347-GLN361
A	GLN1-PHE225
A	ASN274-THR283
A	TYR347-GLN361

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site_id	SWS_FT_FI2
Number of Residues	172
Details	TRANSMEM: Helical => ECO:0000305

Chain	Residue	Details
E	PHE221-ILE242
E	ALA246-LEU268
E	ALA280-VAL302
E	TRP323-VAL344
B	PHE221-ILE242
B	ALA246-LEU268
B	ALA280-VAL302
B	TRP323-VAL344

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: in chain B => ECO:0000250|UniProtKB:P28472

Chain	Residue	Details
E	TYR97
E	SER156
E	THR202
B	TYR97
B	SER156
B	THR202

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: in chain A => ECO:0000269|PubMed:30044221, ECO:0007744|PDB:6DW0, ECO:0007744|PDB:6DW1

Chain	Residue	Details
E	TYR157
B	TYR157
A	ARG66
A	THR129

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN8
B	ASN8

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site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30044221, ECO:0007744|PDB:6DW0, ECO:0007744|PDB:6DW1

Chain	Residue	Details
E	ASN80
E	ASN149
B	ASN80
B	ASN149

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