6DVZ
Cryo-EM structure of mouse TRPV3-Y564A in complex with 2-Aminoethoxydiphenyl borate (2-APB)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0009266 | biological_process | response to temperature stimulus |
| A | 0016020 | cellular_component | membrane |
| A | 0042636 | biological_process | negative regulation of hair cycle |
| A | 0043235 | cellular_component | receptor complex |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0090280 | biological_process | positive regulation of calcium ion import |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005764 | cellular_component | lysosome |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0009266 | biological_process | response to temperature stimulus |
| B | 0016020 | cellular_component | membrane |
| B | 0042636 | biological_process | negative regulation of hair cycle |
| B | 0043235 | cellular_component | receptor complex |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0090280 | biological_process | positive regulation of calcium ion import |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005261 | molecular_function | monoatomic cation channel activity |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005764 | cellular_component | lysosome |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0009266 | biological_process | response to temperature stimulus |
| C | 0016020 | cellular_component | membrane |
| C | 0042636 | biological_process | negative regulation of hair cycle |
| C | 0043235 | cellular_component | receptor complex |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0090280 | biological_process | positive regulation of calcium ion import |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005262 | molecular_function | calcium channel activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005764 | cellular_component | lysosome |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0009266 | biological_process | response to temperature stimulus |
| D | 0016020 | cellular_component | membrane |
| D | 0042636 | biological_process | negative regulation of hair cycle |
| D | 0043235 | cellular_component | receptor complex |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0090280 | biological_process | positive regulation of calcium ion import |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue FZ4 A 801 |
| Chain | Residue |
| A | HIS417 |
| A | LEU420 |
| A | HIS426 |
| A | HIS430 |
| A | ARG693 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue FZ4 A 802 |
| Chain | Residue |
| A | PHE526 |
| A | TYR565 |
| A | SER444 |
| A | TRP493 |
| A | LYS500 |
| A | GLU501 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue FZ4 A 803 |
| Chain | Residue |
| A | VAL458 |
| A | ARG462 |
| A | ARG464 |
| A | ARG487 |
| A | TYR540 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue FZ4 B 802 |
| Chain | Residue |
| B | SER444 |
| B | TRP493 |
| B | LYS500 |
| B | GLU501 |
| B | PHE526 |
| B | TYR565 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue FZ4 C 802 |
| Chain | Residue |
| C | SER444 |
| C | TRP493 |
| C | LYS500 |
| C | GLU501 |
| C | PHE526 |
| C | TYR565 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue FZ4 D 802 |
| Chain | Residue |
| D | SER444 |
| D | TRP493 |
| D | LYS500 |
| D | GLU501 |
| D | PHE526 |
| D | TYR565 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide FZ4 B 801 and HIS B 426 |
| Chain | Residue |
| B | HIS417 |
| B | LEU420 |
| B | LEU422 |
| B | PRO424 |
| B | LEU425 |
| B | THR427 |
| B | LEU428 |
| B | LEU429 |
| B | HIS430 |
| B | ARG693 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide FZ4 B 801 and HIS B 426 |
| Chain | Residue |
| B | HIS417 |
| B | LEU420 |
| B | LEU422 |
| B | PRO424 |
| B | LEU425 |
| B | THR427 |
| B | LEU428 |
| B | LEU429 |
| B | HIS430 |
| B | ARG693 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide FZ4 B 801 and ARG B 693 |
| Chain | Residue |
| B | HIS417 |
| B | LEU420 |
| B | HIS426 |
| B | HIS430 |
| B | GLU689 |
| B | ARG690 |
| B | ILE691 |
| B | TRP692 |
| B | LEU694 |
| B | GLN695 |
| B | ARG696 |
| B | ALA697 |
| site_id | AD1 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide FZ4 B 803 and ARG B 487 |
| Chain | Residue |
| B | VAL458 |
| B | ARG462 |
| B | ARG464 |
| B | ALA474 |
| B | GLN483 |
| B | LEU484 |
| B | LEU485 |
| B | GLY486 |
| B | MET488 |
| B | PHE489 |
| B | VAL490 |
| B | LEU491 |
| B | TYR540 |
| site_id | AD2 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide FZ4 C 801 and HIS C 426 |
| Chain | Residue |
| C | HIS417 |
| C | LEU420 |
| C | LEU422 |
| C | PRO424 |
| C | LEU425 |
| C | THR427 |
| C | LEU428 |
| C | LEU429 |
| C | HIS430 |
| C | ARG693 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide FZ4 C 801 and ARG C 693 |
| Chain | Residue |
| C | ARG696 |
| C | ALA697 |
| C | HIS417 |
| C | LEU420 |
| C | HIS426 |
| C | HIS430 |
| C | GLU689 |
| C | ARG690 |
| C | ILE691 |
| C | TRP692 |
| C | LEU694 |
| C | GLN695 |
| site_id | AD4 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide FZ4 C 801 and HIS C 426 |
| Chain | Residue |
| C | HIS417 |
| C | LEU420 |
| C | LEU422 |
| C | PRO424 |
| C | LEU425 |
| C | THR427 |
| C | LEU428 |
| C | LEU429 |
| C | HIS430 |
| C | ARG693 |
| site_id | AD5 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide FZ4 C 803 and ARG C 487 |
| Chain | Residue |
| C | VAL458 |
| C | ARG462 |
| C | ARG464 |
| C | ALA474 |
| C | GLN483 |
| C | LEU484 |
| C | LEU485 |
| C | GLY486 |
| C | MET488 |
| C | PHE489 |
| C | VAL490 |
| C | LEU491 |
| C | TYR540 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide FZ4 D 801 and HIS D 426 |
| Chain | Residue |
| D | HIS417 |
| D | LEU420 |
| D | LEU422 |
| D | PRO424 |
| D | LEU425 |
| D | THR427 |
| D | LEU428 |
| D | LEU429 |
| D | HIS430 |
| D | ARG693 |
| site_id | AD7 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide FZ4 D 801 and ARG D 693 |
| Chain | Residue |
| D | HIS417 |
| D | LEU420 |
| D | HIS426 |
| D | HIS430 |
| D | GLU689 |
| D | ARG690 |
| D | ILE691 |
| D | TRP692 |
| D | LEU694 |
| D | GLN695 |
| D | ARG696 |
| D | ALA697 |
| site_id | AD8 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide FZ4 D 801 and HIS D 426 |
| Chain | Residue |
| D | HIS417 |
| D | LEU420 |
| D | LEU422 |
| D | PRO424 |
| D | LEU425 |
| D | THR427 |
| D | LEU428 |
| D | LEU429 |
| D | HIS430 |
| D | ARG693 |
| site_id | AD9 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide FZ4 D 803 and ARG D 487 |
| Chain | Residue |
| D | VAL458 |
| D | ARG462 |
| D | ARG464 |
| D | ALA474 |
| D | GLN483 |
| D | LEU484 |
| D | LEU485 |
| D | GLY486 |
| D | MET488 |
| D | PHE489 |
| D | VAL490 |
| D | LEU491 |
| D | TYR540 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 480 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | MET440-TYR460 | |
| B | GLU546-THR566 | |
| B | PHE590-GLU610 | |
| B | TYR650-LEU670 | |
| C | MET440-TYR460 | |
| C | MET488-LEU508 | |
| C | PHE524-TYR544 | |
| C | GLU546-THR566 | |
| C | PHE590-GLU610 | |
| C | TYR650-LEU670 | |
| D | MET440-TYR460 | |
| A | MET488-LEU508 | |
| D | MET488-LEU508 | |
| D | PHE524-TYR544 | |
| D | GLU546-THR566 | |
| D | PHE590-GLU610 | |
| D | TYR650-LEU670 | |
| A | PHE524-TYR544 | |
| A | GLU546-THR566 | |
| A | PHE590-GLU610 | |
| A | TYR650-LEU670 | |
| B | MET440-TYR460 | |
| B | MET488-LEU508 | |
| B | PHE524-TYR544 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 108 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR461-ARG487 | |
| A | LYS545 | |
| B | TYR461-ARG487 | |
| B | LYS545 | |
| C | TYR461-ARG487 | |
| C | LYS545 | |
| D | TYR461-ARG487 | |
| D | LYS545 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 624 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG509-HIS523 | |
| D | ARG509-HIS523 | |
| D | ARG567-LYS589 | |
| D | ASN671-VAL794 | |
| A | ARG567-LYS589 | |
| A | ASN671-VAL794 | |
| B | ARG509-HIS523 | |
| B | ARG567-LYS589 | |
| B | ASN671-VAL794 | |
| C | ARG509-HIS523 | |
| C | ARG567-LYS589 | |
| C | ASN671-VAL794 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 64 |
| Details | INTRAMEM: Pore-forming => ECO:0000255 |
| Chain | Residue | Details |
| A | SER621-ILE637 | |
| B | SER621-ILE637 | |
| C | SER621-ILE637 | |
| D | SER621-ILE637 |
