6DVZ

Cryo-EM structure of mouse TRPV3-Y564A in complex with 2-Aminoethoxydiphenyl borate (2-APB)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0007015	biological_process	actin filament organization
A	0007231	biological_process	osmosensory signaling pathway
A	0009266	biological_process	response to temperature stimulus
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042636	biological_process	negative regulation of hair cycle
A	0042802	molecular_function	identical protein binding
A	0043235	cellular_component	receptor complex
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0090280	biological_process	positive regulation of calcium ion import
A	0098703	biological_process	calcium ion import across plasma membrane
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0007015	biological_process	actin filament organization
B	0007231	biological_process	osmosensory signaling pathway
B	0009266	biological_process	response to temperature stimulus
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042636	biological_process	negative regulation of hair cycle
B	0042802	molecular_function	identical protein binding
B	0043235	cellular_component	receptor complex
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0090280	biological_process	positive regulation of calcium ion import
B	0098703	biological_process	calcium ion import across plasma membrane
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0007015	biological_process	actin filament organization
C	0007231	biological_process	osmosensory signaling pathway
C	0009266	biological_process	response to temperature stimulus
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042636	biological_process	negative regulation of hair cycle
C	0042802	molecular_function	identical protein binding
C	0043235	cellular_component	receptor complex
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0090280	biological_process	positive regulation of calcium ion import
C	0098703	biological_process	calcium ion import across plasma membrane
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005886	cellular_component	plasma membrane
D	0005929	cellular_component	cilium
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0007015	biological_process	actin filament organization
D	0007231	biological_process	osmosensory signaling pathway
D	0009266	biological_process	response to temperature stimulus
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042636	biological_process	negative regulation of hair cycle
D	0042802	molecular_function	identical protein binding
D	0043235	cellular_component	receptor complex
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0090280	biological_process	positive regulation of calcium ion import
D	0098703	biological_process	calcium ion import across plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue FZ4 A 801

Chain	Residue
A	HIS417
A	LEU420
A	HIS426
A	HIS430
A	ARG693

---

site_id	AC2
Number of Residues	6
Details	binding site for residue FZ4 A 802

Chain	Residue
A	PHE526
A	TYR565
A	SER444
A	TRP493
A	LYS500
A	GLU501

---

site_id	AC3
Number of Residues	5
Details	binding site for residue FZ4 A 803

Chain	Residue
A	VAL458
A	ARG462
A	ARG464
A	ARG487
A	TYR540

---

site_id	AC4
Number of Residues	6
Details	binding site for residue FZ4 B 802

Chain	Residue
B	SER444
B	TRP493
B	LYS500
B	GLU501
B	PHE526
B	TYR565

---

site_id	AC5
Number of Residues	6
Details	binding site for residue FZ4 C 802

Chain	Residue
C	SER444
C	TRP493
C	LYS500
C	GLU501
C	PHE526
C	TYR565

---

site_id	AC6
Number of Residues	6
Details	binding site for residue FZ4 D 802

Chain	Residue
D	SER444
D	TRP493
D	LYS500
D	GLU501
D	PHE526
D	TYR565

---

site_id	AC7
Number of Residues	10
Details	binding site for Di-peptide FZ4 B 801 and HIS B 426

Chain	Residue
B	HIS417
B	LEU420
B	LEU422
B	PRO424
B	LEU425
B	THR427
B	LEU428
B	LEU429
B	HIS430
B	ARG693

---

site_id	AC8
Number of Residues	10
Details	binding site for Di-peptide FZ4 B 801 and HIS B 426

Chain	Residue
B	HIS417
B	LEU420
B	LEU422
B	PRO424
B	LEU425
B	THR427
B	LEU428
B	LEU429
B	HIS430
B	ARG693

---

site_id	AC9
Number of Residues	12
Details	binding site for Di-peptide FZ4 B 801 and ARG B 693

Chain	Residue
B	HIS417
B	LEU420
B	HIS426
B	HIS430
B	GLU689
B	ARG690
B	ILE691
B	TRP692
B	LEU694
B	GLN695
B	ARG696
B	ALA697

---

site_id	AD1
Number of Residues	13
Details	binding site for Di-peptide FZ4 B 803 and ARG B 487

Chain	Residue
B	VAL458
B	ARG462
B	ARG464
B	ALA474
B	GLN483
B	LEU484
B	LEU485
B	GLY486
B	MET488
B	PHE489
B	VAL490
B	LEU491
B	TYR540

---

site_id	AD2
Number of Residues	10
Details	binding site for Di-peptide FZ4 C 801 and HIS C 426

Chain	Residue
C	HIS417
C	LEU420
C	LEU422
C	PRO424
C	LEU425
C	THR427
C	LEU428
C	LEU429
C	HIS430
C	ARG693

---

site_id	AD3
Number of Residues	12
Details	binding site for Di-peptide FZ4 C 801 and ARG C 693

Chain	Residue
C	ARG696
C	ALA697
C	HIS417
C	LEU420
C	HIS426
C	HIS430
C	GLU689
C	ARG690
C	ILE691
C	TRP692
C	LEU694
C	GLN695

---

site_id	AD4
Number of Residues	10
Details	binding site for Di-peptide FZ4 C 801 and HIS C 426

Chain	Residue
C	HIS417
C	LEU420
C	LEU422
C	PRO424
C	LEU425
C	THR427
C	LEU428
C	LEU429
C	HIS430
C	ARG693

---

site_id	AD5
Number of Residues	13
Details	binding site for Di-peptide FZ4 C 803 and ARG C 487

Chain	Residue
C	VAL458
C	ARG462
C	ARG464
C	ALA474
C	GLN483
C	LEU484
C	LEU485
C	GLY486
C	MET488
C	PHE489
C	VAL490
C	LEU491
C	TYR540

---

site_id	AD6
Number of Residues	10
Details	binding site for Di-peptide FZ4 D 801 and HIS D 426

Chain	Residue
D	HIS417
D	LEU420
D	LEU422
D	PRO424
D	LEU425
D	THR427
D	LEU428
D	LEU429
D	HIS430
D	ARG693

---

site_id	AD7
Number of Residues	12
Details	binding site for Di-peptide FZ4 D 801 and ARG D 693

Chain	Residue
D	HIS417
D	LEU420
D	HIS426
D	HIS430
D	GLU689
D	ARG690
D	ILE691
D	TRP692
D	LEU694
D	GLN695
D	ARG696
D	ALA697

---

site_id	AD8
Number of Residues	10
Details	binding site for Di-peptide FZ4 D 801 and HIS D 426

Chain	Residue
D	HIS417
D	LEU420
D	LEU422
D	PRO424
D	LEU425
D	THR427
D	LEU428
D	LEU429
D	HIS430
D	ARG693

---

site_id	AD9
Number of Residues	13
Details	binding site for Di-peptide FZ4 D 803 and ARG D 487

Chain	Residue
D	VAL458
D	ARG462
D	ARG464
D	ALA474
D	GLN483
D	LEU484
D	LEU485
D	GLY486
D	MET488
D	PHE489
D	VAL490
D	LEU491
D	TYR540

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	140
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	48
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	152
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	100
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	144
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	124
Details	Repeat: {"description":"ANK 1","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	112
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	116
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	120
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	128
Details	Repeat: {"description":"ANK 5","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	88
Details	Repeat: {"description":"ANK 6","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	88
Details	Repeat: {"description":"ANK 7","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---