Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6DUQ

Structure of a Rho-NusG KOW domain complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006353	biological_process	DNA-templated transcription termination
A	0008186	molecular_function	ATP-dependent activity, acting on RNA
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
B	0000166	molecular_function	nucleotide binding
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006353	biological_process	DNA-templated transcription termination
B	0008186	molecular_function	ATP-dependent activity, acting on RNA
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0042802	molecular_function	identical protein binding
C	0000166	molecular_function	nucleotide binding
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0006353	biological_process	DNA-templated transcription termination
C	0008186	molecular_function	ATP-dependent activity, acting on RNA
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0042802	molecular_function	identical protein binding
D	0000166	molecular_function	nucleotide binding
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006353	biological_process	DNA-templated transcription termination
D	0008186	molecular_function	ATP-dependent activity, acting on RNA
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0042802	molecular_function	identical protein binding
E	0000166	molecular_function	nucleotide binding
E	0003676	molecular_function	nucleic acid binding
E	0003723	molecular_function	RNA binding
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0006353	biological_process	DNA-templated transcription termination
E	0008186	molecular_function	ATP-dependent activity, acting on RNA
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0042802	molecular_function	identical protein binding
F	0000166	molecular_function	nucleotide binding
F	0003676	molecular_function	nucleic acid binding
F	0003723	molecular_function	RNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0006353	biological_process	DNA-templated transcription termination
F	0008186	molecular_function	ATP-dependent activity, acting on RNA
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0042802	molecular_function	identical protein binding
G	0000166	molecular_function	nucleotide binding
G	0003676	molecular_function	nucleic acid binding
G	0003723	molecular_function	RNA binding
G	0004386	molecular_function	helicase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005829	cellular_component	cytosol
G	0006353	biological_process	DNA-templated transcription termination
G	0008186	molecular_function	ATP-dependent activity, acting on RNA
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0042802	molecular_function	identical protein binding
H	0000166	molecular_function	nucleotide binding
H	0003676	molecular_function	nucleic acid binding
H	0003723	molecular_function	RNA binding
H	0004386	molecular_function	helicase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005829	cellular_component	cytosol
H	0006353	biological_process	DNA-templated transcription termination
H	0008186	molecular_function	ATP-dependent activity, acting on RNA
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0042802	molecular_function	identical protein binding
I	0000166	molecular_function	nucleotide binding
I	0003676	molecular_function	nucleic acid binding
I	0003723	molecular_function	RNA binding
I	0004386	molecular_function	helicase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005829	cellular_component	cytosol
I	0006353	biological_process	DNA-templated transcription termination
I	0008186	molecular_function	ATP-dependent activity, acting on RNA
I	0016020	cellular_component	membrane
I	0016787	molecular_function	hydrolase activity
I	0042802	molecular_function	identical protein binding
J	0000166	molecular_function	nucleotide binding
J	0003676	molecular_function	nucleic acid binding
J	0003723	molecular_function	RNA binding
J	0004386	molecular_function	helicase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005829	cellular_component	cytosol
J	0006353	biological_process	DNA-templated transcription termination
J	0008186	molecular_function	ATP-dependent activity, acting on RNA
J	0016020	cellular_component	membrane
J	0016787	molecular_function	hydrolase activity
J	0042802	molecular_function	identical protein binding
K	0000166	molecular_function	nucleotide binding
K	0003676	molecular_function	nucleic acid binding
K	0003723	molecular_function	RNA binding
K	0004386	molecular_function	helicase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005829	cellular_component	cytosol
K	0006353	biological_process	DNA-templated transcription termination
K	0008186	molecular_function	ATP-dependent activity, acting on RNA
K	0016020	cellular_component	membrane
K	0016787	molecular_function	hydrolase activity
K	0042802	molecular_function	identical protein binding
L	0000166	molecular_function	nucleotide binding
L	0003676	molecular_function	nucleic acid binding
L	0003723	molecular_function	RNA binding
L	0004386	molecular_function	helicase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005829	cellular_component	cytosol
L	0006353	biological_process	DNA-templated transcription termination
L	0008186	molecular_function	ATP-dependent activity, acting on RNA
L	0016020	cellular_component	membrane
L	0016787	molecular_function	hydrolase activity
L	0042802	molecular_function	identical protein binding
M	0032784	biological_process	regulation of DNA-templated transcription elongation
N	0032784	biological_process	regulation of DNA-templated transcription elongation
O	0032784	biological_process	regulation of DNA-templated transcription elongation
P	0032784	biological_process	regulation of DNA-templated transcription elongation
Q	0032784	biological_process	regulation of DNA-templated transcription elongation
R	0032784	biological_process	regulation of DNA-templated transcription elongation
S	0032784	biological_process	regulation of DNA-templated transcription elongation
T	0032784	biological_process	regulation of DNA-templated transcription elongation
U	0032784	biological_process	regulation of DNA-templated transcription elongation
V	0032784	biological_process	regulation of DNA-templated transcription elongation
W	0032784	biological_process	regulation of DNA-templated transcription elongation
X	0032784	biological_process	regulation of DNA-templated transcription elongation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ADP L 1000

Chain	Residue
K	ARG366
L	PHE355
L	MG1001
L	BEF1002
K	LYS367
L	PRO179
L	LYS181
L	ALA182
L	GLY183
L	LYS184
L	THR185
L	MET186

site_id	AC2
Number of Residues	3
Details	binding site for residue MG L 1001

Chain	Residue
L	THR185
L	ADP1000
L	BEF1002

site_id	AC3
Number of Residues	8
Details	binding site for residue BEF L 1002

Chain	Residue
K	ARG366
L	PRO180
L	LYS181
L	LYS184
L	ARG212
L	LEU320
L	ADP1000
L	MG1001

site_id	AC4
Number of Residues	12
Details	binding site for residue ADP A 1000

Chain	Residue
A	PRO179
A	LYS181
A	ALA182
A	GLY183
A	LYS184
A	THR185
A	MET186
A	PHE355
A	MG1001
A	BEF1002
F	ARG366
F	LYS367

site_id	AC5
Number of Residues	3
Details	binding site for residue MG A 1001

Chain	Residue
A	THR185
A	ADP1000
A	BEF1002

site_id	AC6
Number of Residues	8
Details	binding site for residue BEF A 1002

Chain	Residue
A	PRO180
A	LYS181
A	LYS184
A	ARG212
A	LEU320
A	ADP1000
A	MG1001
F	ARG366

site_id	AC7
Number of Residues	12
Details	binding site for residue ADP G 1000

Chain	Residue
G	PRO179
G	LYS181
G	ALA182
G	GLY183
G	LYS184
G	THR185
G	MET186
G	PHE355
G	MG1001
G	BEF1002
L	ARG366
L	LYS367

site_id	AC8
Number of Residues	3
Details	binding site for residue MG G 1001

Chain	Residue
G	THR185
G	ADP1000
G	BEF1002

site_id	AC9
Number of Residues	8
Details	binding site for residue BEF G 1002

Chain	Residue
G	PRO180
G	LYS181
G	LYS184
G	ARG212
G	LEU320
G	ADP1000
G	MG1001
L	ARG366

site_id	AD1
Number of Residues	12
Details	binding site for residue ADP B 1000

Chain	Residue
A	ARG366
A	LYS367
B	PRO179
B	LYS181
B	ALA182
B	GLY183
B	LYS184
B	THR185
B	MET186
B	PHE355
B	MG1001
B	BEF1002

site_id	AD2
Number of Residues	3
Details	binding site for residue MG B 1001

Chain	Residue
B	THR185
B	ADP1000
B	BEF1002

site_id	AD3
Number of Residues	8
Details	binding site for residue BEF B 1002

Chain	Residue
A	ARG366
B	PRO180
B	LYS181
B	LYS184
B	ARG212
B	LEU320
B	ADP1000
B	MG1001

site_id	AD4
Number of Residues	12
Details	binding site for residue ADP H 1000

Chain	Residue
H	THR185
H	MET186
H	PHE355
H	MG1001
H	BEF1002
G	ARG366
G	LYS367
H	PRO179
H	LYS181
H	ALA182
H	GLY183
H	LYS184

site_id	AD5
Number of Residues	3
Details	binding site for residue MG H 1001

Chain	Residue
H	THR185
H	ADP1000
H	BEF1002

site_id	AD6
Number of Residues	8
Details	binding site for residue BEF H 1002

Chain	Residue
G	ARG366
H	PRO180
H	LYS181
H	LYS184
H	ARG212
H	LEU320
H	ADP1000
H	MG1001

site_id	AD7
Number of Residues	12
Details	binding site for residue ADP C 1000

Chain	Residue
B	ARG366
B	LYS367
C	PRO179
C	LYS181
C	ALA182
C	GLY183
C	LYS184
C	THR185
C	MET186
C	PHE355
C	MG1001
C	BEF1002

site_id	AD8
Number of Residues	3
Details	binding site for residue MG C 1001

Chain	Residue
C	THR185
C	ADP1000
C	BEF1002

site_id	AD9
Number of Residues	8
Details	binding site for residue BEF C 1002

Chain	Residue
B	ARG366
C	PRO180
C	LYS181
C	LYS184
C	ARG212
C	LEU320
C	ADP1000
C	MG1001

site_id	AE1
Number of Residues	12
Details	binding site for residue ADP I 1000

Chain	Residue
H	ARG366
H	LYS367
I	PRO179
I	LYS181
I	ALA182
I	GLY183
I	LYS184
I	THR185
I	MET186
I	PHE355
I	MG1001
I	BEF1002

site_id	AE2
Number of Residues	3
Details	binding site for residue MG I 1001

Chain	Residue
I	THR185
I	ADP1000
I	BEF1002

site_id	AE3
Number of Residues	8
Details	binding site for residue BEF I 1002

Chain	Residue
H	ARG366
I	PRO180
I	LYS181
I	LYS184
I	ARG212
I	LEU320
I	ADP1000
I	MG1001

site_id	AE4
Number of Residues	12
Details	binding site for residue ADP D 1000

Chain	Residue
C	ARG366
C	LYS367
D	PRO179
D	LYS181
D	ALA182
D	GLY183
D	LYS184
D	THR185
D	MET186
D	PHE355
D	MG1001
D	BEF1002

site_id	AE5
Number of Residues	3
Details	binding site for residue MG D 1001

Chain	Residue
D	THR185
D	ADP1000
D	BEF1002

site_id	AE6
Number of Residues	8
Details	binding site for residue BEF D 1002

Chain	Residue
C	ARG366
D	PRO180
D	LYS181
D	LYS184
D	ARG212
D	LEU320
D	ADP1000
D	MG1001

site_id	AE7
Number of Residues	12
Details	binding site for residue ADP K 1000

Chain	Residue
J	ARG366
J	LYS367
K	PRO179
K	LYS181
K	ALA182
K	GLY183
K	LYS184
K	THR185
K	MET186
K	PHE355
K	MG1001
K	BEF1002

site_id	AE8
Number of Residues	3
Details	binding site for residue MG K 1001

Chain	Residue
K	THR185
K	ADP1000
K	BEF1002

site_id	AE9
Number of Residues	8
Details	binding site for residue BEF K 1002

Chain	Residue
J	ARG366
K	PRO180
K	LYS181
K	LYS184
K	ARG212
K	LEU320
K	ADP1000
K	MG1001

site_id	AF1
Number of Residues	12
Details	binding site for residue ADP F 1000

Chain	Residue
E	ARG366
E	LYS367
F	PRO179
F	LYS181
F	ALA182
F	GLY183
F	LYS184
F	THR185
F	MET186
F	PHE355
F	MG1001
F	BEF1002

site_id	AF2
Number of Residues	3
Details	binding site for residue MG F 1001

Chain	Residue
F	THR185
F	ADP1000
F	BEF1002

site_id	AF3
Number of Residues	8
Details	binding site for residue BEF F 1002

Chain	Residue
E	ARG366
F	PRO180
F	LYS181
F	LYS184
F	ARG212
F	LEU320
F	ADP1000
F	MG1001

site_id	AF4
Number of Residues	12
Details	binding site for residue ADP J 1000

Chain	Residue
I	ARG366
I	LYS367
J	PRO179
J	LYS181
J	ALA182
J	GLY183
J	LYS184
J	THR185
J	MET186
J	PHE355
J	MG1001
J	BEF1002

site_id	AF5
Number of Residues	3
Details	binding site for residue MG J 1001

Chain	Residue
J	THR185
J	ADP1000
J	BEF1002

site_id	AF6
Number of Residues	8
Details	binding site for residue BEF J 1002

Chain	Residue
I	ARG366
J	PRO180
J	LYS181
J	LYS184
J	ARG212
J	LEU320
J	ADP1000
J	MG1001

site_id	AF7
Number of Residues	12
Details	binding site for residue ADP E 1000

Chain	Residue
D	ARG366
D	LYS367
E	PRO179
E	LYS181
E	ALA182
E	GLY183
E	LYS184
E	THR185
E	MET186
E	PHE355
E	MG1001
E	BEF1002

site_id	AF8
Number of Residues	3
Details	binding site for residue MG E 1001

Chain	Residue
E	THR185
E	ADP1000
E	BEF1002

site_id	AF9
Number of Residues	8
Details	binding site for residue BEF E 1002

Chain	Residue
D	ARG366
E	PRO180
E	LYS181
E	LYS184
E	ARG212
E	LEU320
E	ADP1000
E	MG1001

Functional Information from PROSITE/UniProt

site_id	PS01014
Number of Residues	10
Details	NUSG Transcription termination factor nusG signature. IFGRaTPVeL

Chain	Residue	Details
M	ILE164-LEU173

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	900
Details	Domain: {"description":"Rho RNA-BD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01203","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	108
Details	Region: {"description":"RNA-binding 1"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	48
Details	Region: {"description":"RNA-binding 2"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	60
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	72
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Site: {"description":"RNA-binding 2"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)