6DUJ

Crystal structure of A51V variant of Human Cytochrome c

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
A	0006915	biological_process	apoptotic process
A	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
A	0009055	molecular_function	electron transfer activity
A	0020037	molecular_function	heme binding
A	0043293	cellular_component	apoptosome
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
A	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005829	cellular_component	cytosol
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C	0006915	biological_process	apoptotic process
C	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
C	0009055	molecular_function	electron transfer activity
C	0020037	molecular_function	heme binding
C	0043293	cellular_component	apoptosome
C	0045333	biological_process	cellular respiration
C	0046872	molecular_function	metal ion binding
C	0070469	cellular_component	respirasome
C	0097193	biological_process	intrinsic apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue HEC A 201

Chain	Residue
A	LYS13
A	TYR46
A	TYR48
A	THR49
A	VAL51
A	ASN52
A	TRP59
A	LEU68
A	THR78
A	LYS79
A	MET80
A	CYS14
A	ILE81
A	PHE82
A	HOH309
A	CYS17
A	HIS18
A	THR28
A	GLY29
A	PRO30
A	THR40
A	GLY41

---

site_id	AC2
Number of Residues	28
Details	binding site for Di-peptide HEC C 201 and CYS C 14

Chain	Residue
C	PHE10
C	LYS13
C	SER15
C	GLN16
C	GLN16
C	CYS17
C	HIS18
C	THR28
C	THR28
C	PRO30
C	LEU35
C	THR40
C	GLY41
C	TYR46
C	TYR48
C	THR49
C	ASN52
C	TRP59
C	LEU64
C	TYR67
C	LEU68
C	THR78
C	LYS79
C	MET80
C	ILE81
C	PHE82
C	HOH309
C	HOH310

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: covalent => ECO:0000255|PROSITE-ProRule:PRU00433, ECO:0000269|PubMed:23150584

Chain	Residue	Details
A	CYS14
A	CYS17
C	CYS14
C	CYS17

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000255|PROSITE-ProRule:PRU00433, ECO:0000269|PubMed:23150584

Chain	Residue	Details
A	HIS18
C	HIS18

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	MET80
C	MET80

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N-acetylglycine => ECO:0000269|PubMed:13933734

Chain	Residue	Details
A	GLY1
C	GLY1

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62894

Chain	Residue	Details
A	TYR48
A	TYR97
C	TYR48
C	TYR97

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62897

Chain	Residue	Details
A	LYS55
C	LYS55

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62897

Chain	Residue	Details
A	LYS72
C	LYS72

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62897

Chain	Residue	Details
A	LYS99
C	LYS99

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