Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6DU8

Human Polycsytin 2-l1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001581biological_processdetection of chemical stimulus involved in sensory perception of sour taste
A0005227molecular_functioncalcium-activated cation channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005272molecular_functionsodium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0006816biological_processcalcium ion transport
A0007224biological_processsmoothened signaling pathway
A0008092molecular_functioncytoskeletal protein binding
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0009415biological_processresponse to water
A0009986cellular_componentcell surface
A0015269molecular_functioncalcium-activated potassium channel activity
A0016020cellular_componentmembrane
A0031410cellular_componentcytoplasmic vesicle
A0033040molecular_functionsour taste receptor activity
A0034220biological_processmonoatomic ion transmembrane transport
A0034703cellular_componentcation channel complex
A0034704cellular_componentcalcium channel complex
A0035725biological_processsodium ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0042805molecular_functionactinin binding
A0043235cellular_componentreceptor complex
A0044325molecular_functiontransmembrane transporter binding
A0046872molecular_functionmetal ion binding
A0046873molecular_functionmetal ion transmembrane transporter activity
A0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
A0050915biological_processsensory perception of sour taste
A0050982biological_processdetection of mechanical stimulus
A0051262biological_processprotein tetramerization
A0051289biological_processprotein homotetramerization
A0051371molecular_functionmuscle alpha-actinin binding
A0051393molecular_functionalpha-actinin binding
A0055085biological_processtransmembrane transport
A0060170cellular_componentciliary membrane
A0070588biological_processcalcium ion transmembrane transport
A0071467biological_processcellular response to pH
A0071468biological_processcellular response to acidic pH
A0071805biological_processpotassium ion transmembrane transport
A0097730cellular_componentnon-motile cilium
A0098655biological_processmonoatomic cation transmembrane transport
A0160128molecular_functionpH-gated monoatomic ion channel activity
A1990760molecular_functionosmolarity-sensing monoatomic cation channel activity
B0001581biological_processdetection of chemical stimulus involved in sensory perception of sour taste
B0005227molecular_functioncalcium-activated cation channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005272molecular_functionsodium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006812biological_processmonoatomic cation transport
B0006816biological_processcalcium ion transport
B0007224biological_processsmoothened signaling pathway
B0008092molecular_functioncytoskeletal protein binding
B0008324molecular_functionmonoatomic cation transmembrane transporter activity
B0009415biological_processresponse to water
B0009986cellular_componentcell surface
B0015269molecular_functioncalcium-activated potassium channel activity
B0016020cellular_componentmembrane
B0031410cellular_componentcytoplasmic vesicle
B0033040molecular_functionsour taste receptor activity
B0034220biological_processmonoatomic ion transmembrane transport
B0034703cellular_componentcation channel complex
B0034704cellular_componentcalcium channel complex
B0035725biological_processsodium ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0042805molecular_functionactinin binding
B0043235cellular_componentreceptor complex
B0044325molecular_functiontransmembrane transporter binding
B0046872molecular_functionmetal ion binding
B0046873molecular_functionmetal ion transmembrane transporter activity
B0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
B0050915biological_processsensory perception of sour taste
B0050982biological_processdetection of mechanical stimulus
B0051262biological_processprotein tetramerization
B0051289biological_processprotein homotetramerization
B0051371molecular_functionmuscle alpha-actinin binding
B0051393molecular_functionalpha-actinin binding
B0055085biological_processtransmembrane transport
B0060170cellular_componentciliary membrane
B0070588biological_processcalcium ion transmembrane transport
B0071467biological_processcellular response to pH
B0071468biological_processcellular response to acidic pH
B0071805biological_processpotassium ion transmembrane transport
B0097730cellular_componentnon-motile cilium
B0098655biological_processmonoatomic cation transmembrane transport
B0160128molecular_functionpH-gated monoatomic ion channel activity
B1990760molecular_functionosmolarity-sensing monoatomic cation channel activity
C0001581biological_processdetection of chemical stimulus involved in sensory perception of sour taste
C0005227molecular_functioncalcium-activated cation channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005272molecular_functionsodium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006812biological_processmonoatomic cation transport
C0006816biological_processcalcium ion transport
C0007224biological_processsmoothened signaling pathway
C0008092molecular_functioncytoskeletal protein binding
C0008324molecular_functionmonoatomic cation transmembrane transporter activity
C0009415biological_processresponse to water
C0009986cellular_componentcell surface
C0015269molecular_functioncalcium-activated potassium channel activity
C0016020cellular_componentmembrane
C0031410cellular_componentcytoplasmic vesicle
C0033040molecular_functionsour taste receptor activity
C0034220biological_processmonoatomic ion transmembrane transport
C0034703cellular_componentcation channel complex
C0034704cellular_componentcalcium channel complex
C0035725biological_processsodium ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0042805molecular_functionactinin binding
C0043235cellular_componentreceptor complex
C0044325molecular_functiontransmembrane transporter binding
C0046872molecular_functionmetal ion binding
C0046873molecular_functionmetal ion transmembrane transporter activity
C0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
C0050915biological_processsensory perception of sour taste
C0050982biological_processdetection of mechanical stimulus
C0051262biological_processprotein tetramerization
C0051289biological_processprotein homotetramerization
C0051371molecular_functionmuscle alpha-actinin binding
C0051393molecular_functionalpha-actinin binding
C0055085biological_processtransmembrane transport
C0060170cellular_componentciliary membrane
C0070588biological_processcalcium ion transmembrane transport
C0071467biological_processcellular response to pH
C0071468biological_processcellular response to acidic pH
C0071805biological_processpotassium ion transmembrane transport
C0097730cellular_componentnon-motile cilium
C0098655biological_processmonoatomic cation transmembrane transport
C0160128molecular_functionpH-gated monoatomic ion channel activity
C1990760molecular_functionosmolarity-sensing monoatomic cation channel activity
D0001581biological_processdetection of chemical stimulus involved in sensory perception of sour taste
D0005227molecular_functioncalcium-activated cation channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005272molecular_functionsodium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006812biological_processmonoatomic cation transport
D0006816biological_processcalcium ion transport
D0007224biological_processsmoothened signaling pathway
D0008092molecular_functioncytoskeletal protein binding
D0008324molecular_functionmonoatomic cation transmembrane transporter activity
D0009415biological_processresponse to water
D0009986cellular_componentcell surface
D0015269molecular_functioncalcium-activated potassium channel activity
D0016020cellular_componentmembrane
D0031410cellular_componentcytoplasmic vesicle
D0033040molecular_functionsour taste receptor activity
D0034220biological_processmonoatomic ion transmembrane transport
D0034703cellular_componentcation channel complex
D0034704cellular_componentcalcium channel complex
D0035725biological_processsodium ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0042805molecular_functionactinin binding
D0043235cellular_componentreceptor complex
D0044325molecular_functiontransmembrane transporter binding
D0046872molecular_functionmetal ion binding
D0046873molecular_functionmetal ion transmembrane transporter activity
D0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
D0050915biological_processsensory perception of sour taste
D0050982biological_processdetection of mechanical stimulus
D0051262biological_processprotein tetramerization
D0051289biological_processprotein homotetramerization
D0051371molecular_functionmuscle alpha-actinin binding
D0051393molecular_functionalpha-actinin binding
D0055085biological_processtransmembrane transport
D0060170cellular_componentciliary membrane
D0070588biological_processcalcium ion transmembrane transport
D0071467biological_processcellular response to pH
D0071468biological_processcellular response to acidic pH
D0071805biological_processpotassium ion transmembrane transport
D0097730cellular_componentnon-motile cilium
D0098655biological_processmonoatomic cation transmembrane transport
D0160128molecular_functionpH-gated monoatomic ion channel activity
D1990760molecular_functionosmolarity-sensing monoatomic cation channel activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues472
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30004384","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues188
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30004384","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues56
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"30004384","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"A2A259","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30004384","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DU8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

PDB statisticsPDBj update infoContact PDBjnumon