6DU8

Human Polycsytin 2-l1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001581	biological_process	detection of chemical stimulus involved in sensory perception of sour taste
A	0005227	molecular_function	calcium-activated cation channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006816	biological_process	calcium ion transport
A	0007224	biological_process	smoothened signaling pathway
A	0008092	molecular_function	cytoskeletal protein binding
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0009415	biological_process	response to water
A	0009986	cellular_component	cell surface
A	0015269	molecular_function	calcium-activated potassium channel activity
A	0015629	cellular_component	actin cytoskeleton
A	0016020	cellular_component	membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0033040	molecular_function	sour taste receptor activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034703	cellular_component	cation channel complex
A	0034704	cellular_component	calcium channel complex
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0042805	molecular_function	actinin binding
A	0042995	cellular_component	cell projection
A	0043235	cellular_component	receptor complex
A	0044325	molecular_function	transmembrane transporter binding
A	0046872	molecular_function	metal ion binding
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0050912	biological_process	detection of chemical stimulus involved in sensory perception of taste
A	0050915	biological_process	sensory perception of sour taste
A	0050982	biological_process	detection of mechanical stimulus
A	0051262	biological_process	protein tetramerization
A	0051289	biological_process	protein homotetramerization
A	0051371	molecular_function	muscle alpha-actinin binding
A	0051393	molecular_function	alpha-actinin binding
A	0060170	cellular_component	ciliary membrane
A	0070588	biological_process	calcium ion transmembrane transport
A	0071467	biological_process	cellular response to pH
A	0071468	biological_process	cellular response to acidic pH
A	0071805	biological_process	potassium ion transmembrane transport
A	0097730	cellular_component	non-motile cilium
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0098662	biological_process	inorganic cation transmembrane transport
A	0160128	molecular_function	pH-gated monoatomic ion channel activity
A	1990760	molecular_function	osmolarity-sensing monoatomic cation channel activity
B	0001581	biological_process	detection of chemical stimulus involved in sensory perception of sour taste
B	0005227	molecular_function	calcium-activated cation channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0006816	biological_process	calcium ion transport
B	0007224	biological_process	smoothened signaling pathway
B	0008092	molecular_function	cytoskeletal protein binding
B	0008324	molecular_function	monoatomic cation transmembrane transporter activity
B	0009415	biological_process	response to water
B	0009986	cellular_component	cell surface
B	0015269	molecular_function	calcium-activated potassium channel activity
B	0015629	cellular_component	actin cytoskeleton
B	0016020	cellular_component	membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0033040	molecular_function	sour taste receptor activity
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034703	cellular_component	cation channel complex
B	0034704	cellular_component	calcium channel complex
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0042805	molecular_function	actinin binding
B	0042995	cellular_component	cell projection
B	0043235	cellular_component	receptor complex
B	0044325	molecular_function	transmembrane transporter binding
B	0046872	molecular_function	metal ion binding
B	0046873	molecular_function	metal ion transmembrane transporter activity
B	0050912	biological_process	detection of chemical stimulus involved in sensory perception of taste
B	0050915	biological_process	sensory perception of sour taste
B	0050982	biological_process	detection of mechanical stimulus
B	0051262	biological_process	protein tetramerization
B	0051289	biological_process	protein homotetramerization
B	0051371	molecular_function	muscle alpha-actinin binding
B	0051393	molecular_function	alpha-actinin binding
B	0060170	cellular_component	ciliary membrane
B	0070588	biological_process	calcium ion transmembrane transport
B	0071467	biological_process	cellular response to pH
B	0071468	biological_process	cellular response to acidic pH
B	0071805	biological_process	potassium ion transmembrane transport
B	0097730	cellular_component	non-motile cilium
B	0098655	biological_process	monoatomic cation transmembrane transport
B	0098662	biological_process	inorganic cation transmembrane transport
B	0160128	molecular_function	pH-gated monoatomic ion channel activity
B	1990760	molecular_function	osmolarity-sensing monoatomic cation channel activity
C	0001581	biological_process	detection of chemical stimulus involved in sensory perception of sour taste
C	0005227	molecular_function	calcium-activated cation channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0006816	biological_process	calcium ion transport
C	0007224	biological_process	smoothened signaling pathway
C	0008092	molecular_function	cytoskeletal protein binding
C	0008324	molecular_function	monoatomic cation transmembrane transporter activity
C	0009415	biological_process	response to water
C	0009986	cellular_component	cell surface
C	0015269	molecular_function	calcium-activated potassium channel activity
C	0015629	cellular_component	actin cytoskeleton
C	0016020	cellular_component	membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0033040	molecular_function	sour taste receptor activity
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034703	cellular_component	cation channel complex
C	0034704	cellular_component	calcium channel complex
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0042805	molecular_function	actinin binding
C	0042995	cellular_component	cell projection
C	0043235	cellular_component	receptor complex
C	0044325	molecular_function	transmembrane transporter binding
C	0046872	molecular_function	metal ion binding
C	0046873	molecular_function	metal ion transmembrane transporter activity
C	0050912	biological_process	detection of chemical stimulus involved in sensory perception of taste
C	0050915	biological_process	sensory perception of sour taste
C	0050982	biological_process	detection of mechanical stimulus
C	0051262	biological_process	protein tetramerization
C	0051289	biological_process	protein homotetramerization
C	0051371	molecular_function	muscle alpha-actinin binding
C	0051393	molecular_function	alpha-actinin binding
C	0060170	cellular_component	ciliary membrane
C	0070588	biological_process	calcium ion transmembrane transport
C	0071467	biological_process	cellular response to pH
C	0071468	biological_process	cellular response to acidic pH
C	0071805	biological_process	potassium ion transmembrane transport
C	0097730	cellular_component	non-motile cilium
C	0098655	biological_process	monoatomic cation transmembrane transport
C	0098662	biological_process	inorganic cation transmembrane transport
C	0160128	molecular_function	pH-gated monoatomic ion channel activity
C	1990760	molecular_function	osmolarity-sensing monoatomic cation channel activity
D	0001581	biological_process	detection of chemical stimulus involved in sensory perception of sour taste
D	0005227	molecular_function	calcium-activated cation channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005929	cellular_component	cilium
D	0006811	biological_process	monoatomic ion transport
D	0006812	biological_process	monoatomic cation transport
D	0006816	biological_process	calcium ion transport
D	0007224	biological_process	smoothened signaling pathway
D	0008092	molecular_function	cytoskeletal protein binding
D	0008324	molecular_function	monoatomic cation transmembrane transporter activity
D	0009415	biological_process	response to water
D	0009986	cellular_component	cell surface
D	0015269	molecular_function	calcium-activated potassium channel activity
D	0015629	cellular_component	actin cytoskeleton
D	0016020	cellular_component	membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0033040	molecular_function	sour taste receptor activity
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034703	cellular_component	cation channel complex
D	0034704	cellular_component	calcium channel complex
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0042805	molecular_function	actinin binding
D	0042995	cellular_component	cell projection
D	0043235	cellular_component	receptor complex
D	0044325	molecular_function	transmembrane transporter binding
D	0046872	molecular_function	metal ion binding
D	0046873	molecular_function	metal ion transmembrane transporter activity
D	0050912	biological_process	detection of chemical stimulus involved in sensory perception of taste
D	0050915	biological_process	sensory perception of sour taste
D	0050982	biological_process	detection of mechanical stimulus
D	0051262	biological_process	protein tetramerization
D	0051289	biological_process	protein homotetramerization
D	0051371	molecular_function	muscle alpha-actinin binding
D	0051393	molecular_function	alpha-actinin binding
D	0060170	cellular_component	ciliary membrane
D	0070588	biological_process	calcium ion transmembrane transport
D	0071467	biological_process	cellular response to pH
D	0071468	biological_process	cellular response to acidic pH
D	0071805	biological_process	potassium ion transmembrane transport
D	0097730	cellular_component	non-motile cilium
D	0098655	biological_process	monoatomic cation transmembrane transport
D	0098662	biological_process	inorganic cation transmembrane transport
D	0160128	molecular_function	pH-gated monoatomic ion channel activity
D	1990760	molecular_function	osmolarity-sensing monoatomic cation channel activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	472
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30004384","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	188
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30004384","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	56
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"30004384","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"A2A259","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30004384","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DU8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---