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6DU8

Human Polycsytin 2-l1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001581biological_processdetection of chemical stimulus involved in sensory perception of sour taste
A0005227molecular_functioncalcium-activated cation channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005272molecular_functionsodium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006812biological_processmonoatomic cation transport
A0007224biological_processsmoothened signaling pathway
A0008092molecular_functioncytoskeletal protein binding
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0009415biological_processresponse to water
A0009986cellular_componentcell surface
A0015269molecular_functioncalcium-activated potassium channel activity
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0031410cellular_componentcytoplasmic vesicle
A0033040molecular_functionsour taste receptor activity
A0034703cellular_componentcation channel complex
A0034704cellular_componentcalcium channel complex
A0035725biological_processsodium ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0043227cellular_componentmembrane-bounded organelle
A0043231cellular_componentintracellular membrane-bounded organelle
A0043235cellular_componentreceptor complex
A0044325molecular_functiontransmembrane transporter binding
A0046872molecular_functionmetal ion binding
A0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
A0050915biological_processsensory perception of sour taste
A0050982biological_processdetection of mechanical stimulus
A0051262biological_processprotein tetramerization
A0051289biological_processprotein homotetramerization
A0051371molecular_functionmuscle alpha-actinin binding
A0051393molecular_functionalpha-actinin binding
A0060170cellular_componentciliary membrane
A0070588biological_processcalcium ion transmembrane transport
A0071467biological_processcellular response to pH
A0071468biological_processcellular response to acidic pH
A0071805biological_processpotassium ion transmembrane transport
A0097730cellular_componentnon-motile cilium
A0098662biological_processinorganic cation transmembrane transport
B0001581biological_processdetection of chemical stimulus involved in sensory perception of sour taste
B0005227molecular_functioncalcium-activated cation channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005272molecular_functionsodium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005929cellular_componentcilium
B0006812biological_processmonoatomic cation transport
B0007224biological_processsmoothened signaling pathway
B0008092molecular_functioncytoskeletal protein binding
B0008324molecular_functionmonoatomic cation transmembrane transporter activity
B0009415biological_processresponse to water
B0009986cellular_componentcell surface
B0015269molecular_functioncalcium-activated potassium channel activity
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0031410cellular_componentcytoplasmic vesicle
B0033040molecular_functionsour taste receptor activity
B0034703cellular_componentcation channel complex
B0034704cellular_componentcalcium channel complex
B0035725biological_processsodium ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0043227cellular_componentmembrane-bounded organelle
B0043231cellular_componentintracellular membrane-bounded organelle
B0043235cellular_componentreceptor complex
B0044325molecular_functiontransmembrane transporter binding
B0046872molecular_functionmetal ion binding
B0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
B0050915biological_processsensory perception of sour taste
B0050982biological_processdetection of mechanical stimulus
B0051262biological_processprotein tetramerization
B0051289biological_processprotein homotetramerization
B0051371molecular_functionmuscle alpha-actinin binding
B0051393molecular_functionalpha-actinin binding
B0060170cellular_componentciliary membrane
B0070588biological_processcalcium ion transmembrane transport
B0071467biological_processcellular response to pH
B0071468biological_processcellular response to acidic pH
B0071805biological_processpotassium ion transmembrane transport
B0097730cellular_componentnon-motile cilium
B0098662biological_processinorganic cation transmembrane transport
C0001581biological_processdetection of chemical stimulus involved in sensory perception of sour taste
C0005227molecular_functioncalcium-activated cation channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005272molecular_functionsodium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0006812biological_processmonoatomic cation transport
C0007224biological_processsmoothened signaling pathway
C0008092molecular_functioncytoskeletal protein binding
C0008324molecular_functionmonoatomic cation transmembrane transporter activity
C0009415biological_processresponse to water
C0009986cellular_componentcell surface
C0015269molecular_functioncalcium-activated potassium channel activity
C0015629cellular_componentactin cytoskeleton
C0016020cellular_componentmembrane
C0031410cellular_componentcytoplasmic vesicle
C0033040molecular_functionsour taste receptor activity
C0034703cellular_componentcation channel complex
C0034704cellular_componentcalcium channel complex
C0035725biological_processsodium ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0043227cellular_componentmembrane-bounded organelle
C0043231cellular_componentintracellular membrane-bounded organelle
C0043235cellular_componentreceptor complex
C0044325molecular_functiontransmembrane transporter binding
C0046872molecular_functionmetal ion binding
C0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
C0050915biological_processsensory perception of sour taste
C0050982biological_processdetection of mechanical stimulus
C0051262biological_processprotein tetramerization
C0051289biological_processprotein homotetramerization
C0051371molecular_functionmuscle alpha-actinin binding
C0051393molecular_functionalpha-actinin binding
C0060170cellular_componentciliary membrane
C0070588biological_processcalcium ion transmembrane transport
C0071467biological_processcellular response to pH
C0071468biological_processcellular response to acidic pH
C0071805biological_processpotassium ion transmembrane transport
C0097730cellular_componentnon-motile cilium
C0098662biological_processinorganic cation transmembrane transport
D0001581biological_processdetection of chemical stimulus involved in sensory perception of sour taste
D0005227molecular_functioncalcium-activated cation channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005272molecular_functionsodium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005783cellular_componentendoplasmic reticulum
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005929cellular_componentcilium
D0006812biological_processmonoatomic cation transport
D0007224biological_processsmoothened signaling pathway
D0008092molecular_functioncytoskeletal protein binding
D0008324molecular_functionmonoatomic cation transmembrane transporter activity
D0009415biological_processresponse to water
D0009986cellular_componentcell surface
D0015269molecular_functioncalcium-activated potassium channel activity
D0015629cellular_componentactin cytoskeleton
D0016020cellular_componentmembrane
D0031410cellular_componentcytoplasmic vesicle
D0033040molecular_functionsour taste receptor activity
D0034703cellular_componentcation channel complex
D0034704cellular_componentcalcium channel complex
D0035725biological_processsodium ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0043227cellular_componentmembrane-bounded organelle
D0043231cellular_componentintracellular membrane-bounded organelle
D0043235cellular_componentreceptor complex
D0044325molecular_functiontransmembrane transporter binding
D0046872molecular_functionmetal ion binding
D0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
D0050915biological_processsensory perception of sour taste
D0050982biological_processdetection of mechanical stimulus
D0051262biological_processprotein tetramerization
D0051289biological_processprotein homotetramerization
D0051371molecular_functionmuscle alpha-actinin binding
D0051393molecular_functionalpha-actinin binding
D0060170cellular_componentciliary membrane
D0070588biological_processcalcium ion transmembrane transport
D0071467biological_processcellular response to pH
D0071468biological_processcellular response to acidic pH
D0071805biological_processpotassium ion transmembrane transport
D0097730cellular_componentnon-motile cilium
D0098662biological_processinorganic cation transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1520
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:30004384
ChainResidueDetails
AMET1-GLU103
CHIS377-SER384
CLYS455-GLY479
CALA558-SER805
DMET1-GLU103
DHIS377-SER384
DLYS455-GLY479
DALA558-SER805
AHIS377-SER384
ALYS455-GLY479
AALA558-SER805
BMET1-GLU103
BHIS377-SER384
BLYS455-GLY479
BALA558-SER805
CMET1-GLU103

site_idSWS_FT_FI2
Number of Residues472
DetailsTRANSMEM: Helical => ECO:0000305|PubMed:30004384
ChainResidueDetails
ALEU104-SER124
BTRP434-PHE454
BPHE480-PHE499
BGLY537-LEU557
CLEU104-SER124
CVAL357-ILE376
CILE385-ILE405
CTRP434-PHE454
CPHE480-PHE499
CGLY537-LEU557
DLEU104-SER124
AVAL357-ILE376
DVAL357-ILE376
DILE385-ILE405
DTRP434-PHE454
DPHE480-PHE499
DGLY537-LEU557
AILE385-ILE405
ATRP434-PHE454
APHE480-PHE499
AGLY537-LEU557
BLEU104-SER124
BVAL357-ILE376
BILE385-ILE405

site_idSWS_FT_FI3
Number of Residues1112
DetailsTOPO_DOM: Extracellular => ECO:0000305|PubMed:30004384
ChainResidueDetails
ASER125-GLU356
CPHE406-PHE433
CGLY500-LYS511
CASN527-LEU536
DSER125-GLU356
DPHE406-PHE433
DGLY500-LYS511
DASN527-LEU536
APHE406-PHE433
AGLY500-LYS511
AASN527-LEU536
BSER125-GLU356
BPHE406-PHE433
BGLY500-LYS511
BASN527-LEU536
CSER125-GLU356

site_idSWS_FT_FI4
Number of Residues56
DetailsINTRAMEM: Pore-forming => ECO:0000305|PubMed:30004384
ChainResidueDetails
ACYS512-TYR526
BCYS512-TYR526
CCYS512-TYR526
DCYS512-TYR526

site_idSWS_FT_FI5
Number of Residues16
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
AASP646
CASP648
CASN650
CGLU657
DASP646
DASP648
DASN650
DGLU657
AASP648
AASN650
AGLU657
BASP646
BASP648
BASN650
BGLU657
CASP646

site_idSWS_FT_FI6
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:27754867
ChainResidueDetails
ACYS38
BCYS38
CCYS38
DCYS38

site_idSWS_FT_FI7
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN177
DASN177
DASN241
DASN505
AASN241
AASN505
BASN177
BASN241
BASN505
CASN177
CASN241
CASN505

site_idSWS_FT_FI8
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30004384, ECO:0007744|PDB:6DU8
ChainResidueDetails
AASN207
BASN207
CASN207
DASN207

221371

PDB entries from 2024-06-19

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