6DS2

Crystal structure of Ni(II)-bound human calprotectin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002523	biological_process	leukocyte migration involved in inflammatory response
A	0002544	biological_process	chronic inflammatory response
A	0002790	biological_process	peptide secretion
A	0002793	biological_process	positive regulation of peptide secretion
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006914	biological_process	autophagy
A	0006915	biological_process	apoptotic process
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0008017	molecular_function	microtubule binding
A	0008270	molecular_function	zinc ion binding
A	0010043	biological_process	response to zinc ion
A	0014002	biological_process	astrocyte development
A	0018119	biological_process	peptidyl-cysteine S-nitrosylation
A	0030307	biological_process	positive regulation of cell growth
A	0030593	biological_process	neutrophil chemotaxis
A	0032119	biological_process	sequestering of zinc ion
A	0032496	biological_process	response to lipopolysaccharide
A	0034121	biological_process	regulation of toll-like receptor signaling pathway
A	0034774	cellular_component	secretory granule lumen
A	0035425	biological_process	autocrine signaling
A	0035662	molecular_function	Toll-like receptor 4 binding
A	0042742	biological_process	defense response to bacterium
A	0045087	biological_process	innate immune response
A	0045111	cellular_component	intermediate filament cytoskeleton
A	0045471	biological_process	response to ethanol
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0050544	molecular_function	arachidonate binding
A	0050729	biological_process	positive regulation of inflammatory response
A	0050786	molecular_function	RAGE receptor binding
A	0050832	biological_process	defense response to fungus
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051493	biological_process	regulation of cytoskeleton organization
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0070062	cellular_component	extracellular exosome
A	0070488	biological_process	neutrophil aggregation
A	1990660	cellular_component	calprotectin complex
A	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
A	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
B	0002523	biological_process	leukocyte migration involved in inflammatory response
B	0002544	biological_process	chronic inflammatory response
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0006914	biological_process	autophagy
B	0006915	biological_process	apoptotic process
B	0006935	biological_process	chemotaxis
B	0006954	biological_process	inflammatory response
B	0007267	biological_process	cell-cell signaling
B	0008017	molecular_function	microtubule binding
B	0008270	molecular_function	zinc ion binding
B	0010976	biological_process	positive regulation of neuron projection development
B	0014002	biological_process	astrocyte development
B	0016209	molecular_function	antioxidant activity
B	0030307	biological_process	positive regulation of cell growth
B	0030593	biological_process	neutrophil chemotaxis
B	0032119	biological_process	sequestering of zinc ion
B	0034121	biological_process	regulation of toll-like receptor signaling pathway
B	0034774	cellular_component	secretory granule lumen
B	0035425	biological_process	autocrine signaling
B	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
B	0035662	molecular_function	Toll-like receptor 4 binding
B	0035821	biological_process	modulation of process of another organism
B	0042742	biological_process	defense response to bacterium
B	0043542	biological_process	endothelial cell migration
B	0045087	biological_process	innate immune response
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0050544	molecular_function	arachidonate binding
B	0050729	biological_process	positive regulation of inflammatory response
B	0050786	molecular_function	RAGE receptor binding
B	0050832	biological_process	defense response to fungus
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0051493	biological_process	regulation of cytoskeleton organization
B	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0062023	cellular_component	collagen-containing extracellular matrix
B	0070062	cellular_component	extracellular exosome
B	0070488	biological_process	neutrophil aggregation
B	0098869	biological_process	cellular oxidant detoxification
B	1990660	cellular_component	calprotectin complex
B	1990662	cellular_component	S100A9 complex
B	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
B	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
C	0002523	biological_process	leukocyte migration involved in inflammatory response
C	0002544	biological_process	chronic inflammatory response
C	0002790	biological_process	peptide secretion
C	0002793	biological_process	positive regulation of peptide secretion
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0006914	biological_process	autophagy
C	0006915	biological_process	apoptotic process
C	0006935	biological_process	chemotaxis
C	0006954	biological_process	inflammatory response
C	0008017	molecular_function	microtubule binding
C	0008270	molecular_function	zinc ion binding
C	0010043	biological_process	response to zinc ion
C	0014002	biological_process	astrocyte development
C	0018119	biological_process	peptidyl-cysteine S-nitrosylation
C	0030307	biological_process	positive regulation of cell growth
C	0030593	biological_process	neutrophil chemotaxis
C	0032119	biological_process	sequestering of zinc ion
C	0032496	biological_process	response to lipopolysaccharide
C	0034121	biological_process	regulation of toll-like receptor signaling pathway
C	0034774	cellular_component	secretory granule lumen
C	0035425	biological_process	autocrine signaling
C	0035662	molecular_function	Toll-like receptor 4 binding
C	0042742	biological_process	defense response to bacterium
C	0045087	biological_process	innate immune response
C	0045111	cellular_component	intermediate filament cytoskeleton
C	0045471	biological_process	response to ethanol
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0050544	molecular_function	arachidonate binding
C	0050729	biological_process	positive regulation of inflammatory response
C	0050786	molecular_function	RAGE receptor binding
C	0050832	biological_process	defense response to fungus
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0051493	biological_process	regulation of cytoskeleton organization
C	0062023	cellular_component	collagen-containing extracellular matrix
C	0070062	cellular_component	extracellular exosome
C	0070488	biological_process	neutrophil aggregation
C	1990660	cellular_component	calprotectin complex
C	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
C	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
D	0002523	biological_process	leukocyte migration involved in inflammatory response
D	0002544	biological_process	chronic inflammatory response
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0006914	biological_process	autophagy
D	0006915	biological_process	apoptotic process
D	0006935	biological_process	chemotaxis
D	0006954	biological_process	inflammatory response
D	0007267	biological_process	cell-cell signaling
D	0008017	molecular_function	microtubule binding
D	0008270	molecular_function	zinc ion binding
D	0010976	biological_process	positive regulation of neuron projection development
D	0014002	biological_process	astrocyte development
D	0016209	molecular_function	antioxidant activity
D	0030307	biological_process	positive regulation of cell growth
D	0030593	biological_process	neutrophil chemotaxis
D	0032119	biological_process	sequestering of zinc ion
D	0034121	biological_process	regulation of toll-like receptor signaling pathway
D	0034774	cellular_component	secretory granule lumen
D	0035425	biological_process	autocrine signaling
D	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
D	0035662	molecular_function	Toll-like receptor 4 binding
D	0035821	biological_process	modulation of process of another organism
D	0042742	biological_process	defense response to bacterium
D	0043542	biological_process	endothelial cell migration
D	0045087	biological_process	innate immune response
D	0046872	molecular_function	metal ion binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0050544	molecular_function	arachidonate binding
D	0050729	biological_process	positive regulation of inflammatory response
D	0050786	molecular_function	RAGE receptor binding
D	0050832	biological_process	defense response to fungus
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0051493	biological_process	regulation of cytoskeleton organization
D	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0062023	cellular_component	collagen-containing extracellular matrix
D	0070062	cellular_component	extracellular exosome
D	0070488	biological_process	neutrophil aggregation
D	0098869	biological_process	cellular oxidant detoxification
D	1990660	cellular_component	calprotectin complex
D	1990662	cellular_component	S100A9 complex
D	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
D	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
E	0002523	biological_process	leukocyte migration involved in inflammatory response
E	0002544	biological_process	chronic inflammatory response
E	0002790	biological_process	peptide secretion
E	0002793	biological_process	positive regulation of peptide secretion
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005886	cellular_component	plasma membrane
E	0006914	biological_process	autophagy
E	0006915	biological_process	apoptotic process
E	0006935	biological_process	chemotaxis
E	0006954	biological_process	inflammatory response
E	0008017	molecular_function	microtubule binding
E	0008270	molecular_function	zinc ion binding
E	0010043	biological_process	response to zinc ion
E	0014002	biological_process	astrocyte development
E	0018119	biological_process	peptidyl-cysteine S-nitrosylation
E	0030307	biological_process	positive regulation of cell growth
E	0030593	biological_process	neutrophil chemotaxis
E	0032119	biological_process	sequestering of zinc ion
E	0032496	biological_process	response to lipopolysaccharide
E	0034121	biological_process	regulation of toll-like receptor signaling pathway
E	0034774	cellular_component	secretory granule lumen
E	0035425	biological_process	autocrine signaling
E	0035662	molecular_function	Toll-like receptor 4 binding
E	0042742	biological_process	defense response to bacterium
E	0045087	biological_process	innate immune response
E	0045111	cellular_component	intermediate filament cytoskeleton
E	0045471	biological_process	response to ethanol
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050544	molecular_function	arachidonate binding
E	0050729	biological_process	positive regulation of inflammatory response
E	0050786	molecular_function	RAGE receptor binding
E	0050832	biological_process	defense response to fungus
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0051493	biological_process	regulation of cytoskeleton organization
E	0062023	cellular_component	collagen-containing extracellular matrix
E	0070062	cellular_component	extracellular exosome
E	0070488	biological_process	neutrophil aggregation
E	1990660	cellular_component	calprotectin complex
E	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
E	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
F	0002523	biological_process	leukocyte migration involved in inflammatory response
F	0002544	biological_process	chronic inflammatory response
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0006914	biological_process	autophagy
F	0006915	biological_process	apoptotic process
F	0006935	biological_process	chemotaxis
F	0006954	biological_process	inflammatory response
F	0007267	biological_process	cell-cell signaling
F	0008017	molecular_function	microtubule binding
F	0008270	molecular_function	zinc ion binding
F	0010976	biological_process	positive regulation of neuron projection development
F	0014002	biological_process	astrocyte development
F	0016209	molecular_function	antioxidant activity
F	0030307	biological_process	positive regulation of cell growth
F	0030593	biological_process	neutrophil chemotaxis
F	0032119	biological_process	sequestering of zinc ion
F	0034121	biological_process	regulation of toll-like receptor signaling pathway
F	0034774	cellular_component	secretory granule lumen
F	0035425	biological_process	autocrine signaling
F	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
F	0035662	molecular_function	Toll-like receptor 4 binding
F	0035821	biological_process	modulation of process of another organism
F	0042742	biological_process	defense response to bacterium
F	0043542	biological_process	endothelial cell migration
F	0045087	biological_process	innate immune response
F	0046872	molecular_function	metal ion binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0050544	molecular_function	arachidonate binding
F	0050729	biological_process	positive regulation of inflammatory response
F	0050786	molecular_function	RAGE receptor binding
F	0050832	biological_process	defense response to fungus
F	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
F	0051493	biological_process	regulation of cytoskeleton organization
F	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
F	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
F	0062023	cellular_component	collagen-containing extracellular matrix
F	0070062	cellular_component	extracellular exosome
F	0070488	biological_process	neutrophil aggregation
F	0098869	biological_process	cellular oxidant detoxification
F	1990660	cellular_component	calprotectin complex
F	1990662	cellular_component	S100A9 complex
F	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
F	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
G	0002523	biological_process	leukocyte migration involved in inflammatory response
G	0002544	biological_process	chronic inflammatory response
G	0002790	biological_process	peptide secretion
G	0002793	biological_process	positive regulation of peptide secretion
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0006914	biological_process	autophagy
G	0006915	biological_process	apoptotic process
G	0006935	biological_process	chemotaxis
G	0006954	biological_process	inflammatory response
G	0008017	molecular_function	microtubule binding
G	0008270	molecular_function	zinc ion binding
G	0010043	biological_process	response to zinc ion
G	0014002	biological_process	astrocyte development
G	0018119	biological_process	peptidyl-cysteine S-nitrosylation
G	0030307	biological_process	positive regulation of cell growth
G	0030593	biological_process	neutrophil chemotaxis
G	0032119	biological_process	sequestering of zinc ion
G	0032496	biological_process	response to lipopolysaccharide
G	0034121	biological_process	regulation of toll-like receptor signaling pathway
G	0034774	cellular_component	secretory granule lumen
G	0035425	biological_process	autocrine signaling
G	0035662	molecular_function	Toll-like receptor 4 binding
G	0042742	biological_process	defense response to bacterium
G	0045087	biological_process	innate immune response
G	0045111	cellular_component	intermediate filament cytoskeleton
G	0045471	biological_process	response to ethanol
G	0046872	molecular_function	metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0050544	molecular_function	arachidonate binding
G	0050729	biological_process	positive regulation of inflammatory response
G	0050786	molecular_function	RAGE receptor binding
G	0050832	biological_process	defense response to fungus
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0051493	biological_process	regulation of cytoskeleton organization
G	0062023	cellular_component	collagen-containing extracellular matrix
G	0070062	cellular_component	extracellular exosome
G	0070488	biological_process	neutrophil aggregation
G	1990660	cellular_component	calprotectin complex
G	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
G	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
H	0002523	biological_process	leukocyte migration involved in inflammatory response
H	0002544	biological_process	chronic inflammatory response
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0006914	biological_process	autophagy
H	0006915	biological_process	apoptotic process
H	0006935	biological_process	chemotaxis
H	0006954	biological_process	inflammatory response
H	0007267	biological_process	cell-cell signaling
H	0008017	molecular_function	microtubule binding
H	0008270	molecular_function	zinc ion binding
H	0010976	biological_process	positive regulation of neuron projection development
H	0014002	biological_process	astrocyte development
H	0016209	molecular_function	antioxidant activity
H	0030307	biological_process	positive regulation of cell growth
H	0030593	biological_process	neutrophil chemotaxis
H	0032119	biological_process	sequestering of zinc ion
H	0034121	biological_process	regulation of toll-like receptor signaling pathway
H	0034774	cellular_component	secretory granule lumen
H	0035425	biological_process	autocrine signaling
H	0035606	biological_process	peptidyl-cysteine S-trans-nitrosylation
H	0035662	molecular_function	Toll-like receptor 4 binding
H	0035821	biological_process	modulation of process of another organism
H	0042742	biological_process	defense response to bacterium
H	0043542	biological_process	endothelial cell migration
H	0045087	biological_process	innate immune response
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0050544	molecular_function	arachidonate binding
H	0050729	biological_process	positive regulation of inflammatory response
H	0050786	molecular_function	RAGE receptor binding
H	0050832	biological_process	defense response to fungus
H	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
H	0051493	biological_process	regulation of cytoskeleton organization
H	0060264	biological_process	regulation of respiratory burst involved in inflammatory response
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
H	0062023	cellular_component	collagen-containing extracellular matrix
H	0070062	cellular_component	extracellular exosome
H	0070488	biological_process	neutrophil aggregation
H	0098869	biological_process	cellular oxidant detoxification
H	1990660	cellular_component	calprotectin complex
H	1990662	cellular_component	S100A9 complex
H	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
H	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue NA A 101

Chain	Residue
A	SER20
A	LYS23
A	ASN25
A	ALA28
A	TYR30
A	HOH230

---

site_id	AC2
Number of Residues	6
Details	binding site for residue NA A 102

Chain	Residue
A	ALA65
A	GLU70
A	HOH214
A	ASP59
A	ASN61
A	ASP63

---

site_id	AC3
Number of Residues	6
Details	binding site for residue NI B 201

Chain	Residue
A	HIS17
A	HIS27
B	HIS91
B	HIS95
B	HIS103
B	HIS105

---

site_id	AC4
Number of Residues	5
Details	binding site for residue NI C 101

Chain	Residue
C	HIS83
C	HIS87
D	HIS20
D	ASP30
D	HOH338

---

site_id	AC5
Number of Residues	6
Details	binding site for residue NA C 102

Chain	Residue
C	SER20
C	LYS23
C	ASN25
C	ALA28
C	TYR30
C	HOH220

---

site_id	AC6
Number of Residues	6
Details	binding site for residue NA C 103

Chain	Residue
C	ASP59
C	ASN61
C	ASP63
C	ALA65
C	GLU70
C	HOH205

---

site_id	AC7
Number of Residues	6
Details	binding site for residue NI D 201

Chain	Residue
C	HIS17
C	HIS27
D	HIS91
D	HIS95
D	HIS103
D	HIS105

---

site_id	AC8
Number of Residues	6
Details	binding site for residue NA D 202

Chain	Residue
D	SER23
D	LEU26
D	HIS28
D	THR31
D	HOH313
D	HOH325

---

site_id	AC9
Number of Residues	5
Details	binding site for residue NI E 101

Chain	Residue
E	HIS83
E	HIS87
F	HIS20
F	ASP30
F	HOH307

---

site_id	AD1
Number of Residues	5
Details	binding site for residue NA E 102

Chain	Residue
E	SER20
E	LYS23
E	ASN25
E	ALA28
E	HOH224

---

site_id	AD2
Number of Residues	6
Details	binding site for residue NA E 103

Chain	Residue
E	ASP59
E	ASN61
E	ASP63
E	ALA65
E	GLU70
E	HOH220

---

site_id	AD3
Number of Residues	6
Details	binding site for residue NI F 201

Chain	Residue
E	HIS17
E	HIS27
F	HIS91
F	HIS95
F	HIS103
F	HIS105

---

site_id	AD4
Number of Residues	6
Details	binding site for residue NA F 202

Chain	Residue
F	SER23
F	LEU26
F	HIS28
F	THR31
F	HOH312
F	HOH313

---

site_id	AD5
Number of Residues	6
Details	binding site for residue NA G 101

Chain	Residue
G	SER20
G	LYS23
G	ASN25
G	ALA28
G	TYR30
G	HOH201

---

site_id	AD6
Number of Residues	6
Details	binding site for residue NA G 102

Chain	Residue
G	ASP59
G	ASN61
G	ASP63
G	ALA65
G	GLU70
G	HOH204

---

site_id	AD7
Number of Residues	6
Details	binding site for residue NI H 201

Chain	Residue
G	HIS17
G	HIS27
H	HIS91
H	HIS95
H	HIS103
H	HIS105

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DTNADKQLSfeEF

Chain	Residue	Details
B	ASP67-PHE79
A	ASP59-PHE71

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. IMedLDtnaDkqlSFeEFimLM

Chain	Residue	Details
B	ILE62-MET83
A	TRP54-VAL75

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000305|PubMed:17553524

Chain	Residue	Details
B	HIS20
F	ASP30
F	HIS91
F	HIS95
H	HIS20
H	ASP30
H	HIS91
H	HIS95
G	HIS27
G	ASP33
G	HIS83
B	ASP30
G	HIS87
B	HIS91
B	HIS95
D	HIS20
D	ASP30
D	HIS91
D	HIS95
F	HIS20

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:11851337, ECO:0000269|PubMed:17553524, ECO:0007744|PDB:1IRJ, ECO:0007744|PDB:1XK4

Chain	Residue	Details
B	SER23
D	GLU36
F	SER23
F	LEU26
F	HIS28
F	THR31
F	GLU36
H	SER23
H	LEU26
H	HIS28
H	THR31
B	LEU26
H	GLU36
B	HIS28
B	THR31
B	GLU36
D	SER23
D	LEU26
D	HIS28
D	THR31

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:11851337, ECO:0000269|PubMed:17553524, ECO:0007744|PDB:1IRJ, ECO:0007744|PDB:1XK4

Chain	Residue	Details
B	ASP67
D	GLU78
F	ASP67
F	ASN69
F	ASP71
F	GLN73
F	GLU78
H	ASP67
H	ASN69
H	ASP71
H	GLN73
B	ASN69
H	GLU78
B	ASP71
B	GLN73
B	GLU78
D	ASP67
D	ASN69
D	ASP71
D	GLN73

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Blocked amino end (Thr)

Chain	Residue	Details
B	THR2
D	THR2
F	THR2
H	THR2

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine; transient => ECO:0000305|PubMed:25417112

Chain	Residue	Details
B	SER3
D	SER3
F	SER3
H	SER3

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Pros-methylhistidine => ECO:0000250|UniProtKB:P50116

Chain	Residue	Details
B	HIS105
D	HIS105
F	HIS105
H	HIS105

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:15331440, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:2478889, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:19367720, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	THR113
D	THR113
F	THR113
H	THR113

---