6DRY
Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004993 | molecular_function | G protein-coupled serotonin receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue H8D A 2001 |
| Chain | Residue |
| A | ASP135 |
| A | THR140 |
| A | VAL208 |
| A | LEU209 |
| A | PHE217 |
| A | GLY221 |
| A | ALA225 |
| A | PHE340 |
| A | LEU362 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CLR A 2002 |
| Chain | Residue |
| A | ILE61 |
| A | GLY70 |
| A | TYR394 |
| A | TYR399 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue OLA A 2003 |
| Chain | Residue |
| A | GLY185 |
| A | LYS193 |
| A | ASP216 |
| A | PHE217 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue OLC A 2004 |
| Chain | Residue |
| A | HIS55 |
| A | ALA58 |
| A | SER150 |
| A | MET233 |
| A | TYR237 |
| A | THR240 |
| A | SER323 |
| A | LEU326 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue PEG A 2005 |
| Chain | Residue |
| A | TYR380 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 2006 |
| Chain | Residue |
| A | GLN1041 |
| A | LYS1047 |
| A | ASP1060 |
| A | ARG1062 |
| A | HIS1063 |
| A | HIS1063 |
| A | ASP1066 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 A 2007 |
| Chain | Residue |
| A | ARG388 |
| A | GLY392 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwHLCAISVDRYIaI |
| Chain | Residue | Details |
| A | ALA141-ILE157 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581 |
| Chain | Residue | Details |
| A | ALA57-VAL79 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 29 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581 |
| Chain | Residue | Details |
| A | SER80-ASN90 | |
| A | ASP152-THR171 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581 |
| Chain | Residue | Details |
| A | TYR91-LEU113 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 52 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581 |
| Chain | Residue | Details |
| A | THR114-PRO129 | |
| A | LYS193-ASP216 | |
| A | THR346-MET360 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581 |
| Chain | Residue | Details |
| A | ALA130-VAL151 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581 |
| Chain | Residue | Details |
| A | ALA172-ILE192 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581 |
| Chain | Residue | Details |
| A | PHE217-LEU239 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581 |
| Chain | Residue | Details |
| A | VAL325-ILE345 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581 |
| Chain | Residue | Details |
| A | LEU361-LEU382 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23519215, ECO:0007744|PDB:4IB4, ECO:0007744|PDB:4NC3 |
| Chain | Residue | Details |
| A | ASP135 | |
| A | THR140 | |
| A | LEU209 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | SITE: Hydrophobic barrier that decreases the speed of ligand binding and dissociation => ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| A | LEU209 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
| Chain | Residue | Details |
| A | CYS397 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | TRP1007 |
