6DQ4
LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR GSK-J1
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue K0I A 601 |
| Chain | Residue |
| A | ARG73 |
| A | LYS501 |
| A | LEU536 |
| A | MN602 |
| A | GOL605 |
| A | DMS611 |
| A | HOH731 |
| A | TYR409 |
| A | ALA411 |
| A | ASP412 |
| A | TYR472 |
| A | PHE480 |
| A | HIS483 |
| A | GLU485 |
| A | ASN493 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 602 |
| Chain | Residue |
| A | HIS483 |
| A | GLU485 |
| A | K0I601 |
| A | HOH726 |
| A | HOH731 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | LYS45 |
| A | ARG73 |
| A | HIS509 |
| A | TYR553 |
| A | HOH740 |
| A | HOH764 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | PHE61 |
| A | ILE459 |
| A | TRP497 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 605 |
| Chain | Residue |
| A | PHE480 |
| A | CYS481 |
| A | HIS483 |
| A | GLN535 |
| A | K0I601 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 606 |
| Chain | Residue |
| A | MET380 |
| A | PRO381 |
| A | GLU485 |
| A | HIS487 |
| A | TRP488 |
| A | HOH704 |
| A | HOH763 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 607 |
| Chain | Residue |
| A | ARG69 |
| A | PHE70 |
| A | THR71 |
| A | ASP417 |
| A | PHE418 |
| A | HOH702 |
| A | HOH703 |
| A | HOH854 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 608 |
| Chain | Residue |
| A | ASN556 |
| A | HOH735 |
| A | HOH795 |
| A | HOH881 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 609 |
| Chain | Residue |
| A | GLU64 |
| A | VAL65 |
| A | LYS66 |
| A | ARG429 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 610 |
| Chain | Residue |
| A | GLY353 |
| A | GLN356 |
| A | ALA357 |
| A | MET384 |
| A | TRP488 |
| A | SER508 |
| A | PRO567 |
| A | HOH848 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue DMS A 611 |
| Chain | Residue |
| A | LYS45 |
| A | GLN75 |
| A | ARG76 |
| A | GLU79 |
| A | CYS481 |
| A | LEU536 |
| A | K0I601 |
| A | HOH754 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 612 |
| Chain | Residue |
| A | MET518 |
| A | ASP531 |
| A | HIS534 |
| A | GLN535 |
| A | TYR570 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 41 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Motif: {"description":"GSGFP motif","evidences":[{"source":"UniProtKB","id":"Q3UXZ9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214401","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27499454","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214401","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27499454","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
