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6DNZ

Trypanosoma brucei PRMT1 enzyme-prozyme heterotetrameric complex with AdoHcy

Functional Information from GO Data
ChainGOidnamespacecontents
A0003729molecular_functionmRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0006338biological_processchromatin remodeling
A0006355biological_processregulation of DNA-templated transcription
A0008168molecular_functionmethyltransferase activity
A0009267biological_processcellular response to starvation
A0016273molecular_functionarginine N-methyltransferase activity
A0016274molecular_functionprotein-arginine N-methyltransferase activity
A0016740molecular_functiontransferase activity
A0018216biological_processpeptidyl-arginine methylation
A0019222biological_processregulation of metabolic process
A0019919biological_processpeptidyl-arginine methylation, to asymmetrical-dimethyl arginine
A0032259biological_processmethylation
A0035241molecular_functionprotein-arginine omega-N monomethyltransferase activity
A0035242molecular_functionprotein-arginine omega-N asymmetric methyltransferase activity
A0042054molecular_functionhistone methyltransferase activity
A0045821biological_processpositive regulation of glycolytic process
A2001157biological_processnegative regulation of L-proline catabolic process to L-glutamate
B0003729molecular_functionmRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0006338biological_processchromatin remodeling
B0006355biological_processregulation of DNA-templated transcription
B0008168molecular_functionmethyltransferase activity
B0016274molecular_functionprotein-arginine N-methyltransferase activity
B0016740molecular_functiontransferase activity
B0018216biological_processpeptidyl-arginine methylation
B0032259biological_processmethylation
B0042054molecular_functionhistone methyltransferase activity
C0003729molecular_functionmRNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0006338biological_processchromatin remodeling
C0006355biological_processregulation of DNA-templated transcription
C0008168molecular_functionmethyltransferase activity
C0009267biological_processcellular response to starvation
C0016273molecular_functionarginine N-methyltransferase activity
C0016274molecular_functionprotein-arginine N-methyltransferase activity
C0016740molecular_functiontransferase activity
C0018216biological_processpeptidyl-arginine methylation
C0019222biological_processregulation of metabolic process
C0019919biological_processpeptidyl-arginine methylation, to asymmetrical-dimethyl arginine
C0032259biological_processmethylation
C0035241molecular_functionprotein-arginine omega-N monomethyltransferase activity
C0035242molecular_functionprotein-arginine omega-N asymmetric methyltransferase activity
C0042054molecular_functionhistone methyltransferase activity
C0045821biological_processpositive regulation of glycolytic process
C2001157biological_processnegative regulation of L-proline catabolic process to L-glutamate
D0003729molecular_functionmRNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0006338biological_processchromatin remodeling
D0006355biological_processregulation of DNA-templated transcription
D0008168molecular_functionmethyltransferase activity
D0016274molecular_functionprotein-arginine N-methyltransferase activity
D0016740molecular_functiontransferase activity
D0018216biological_processpeptidyl-arginine methylation
D0032259biological_processmethylation
D0042054molecular_functionhistone methyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue SAH A 401
ChainResidue
ATYR22
ASER85
AGLY109
ALYS110
AVAL111
AGLU112
AGLU126
AMSE137
ATHR140
AHOH502
AHOH511
AHIS28
AHOH535
AARG37
AGLY61
ACYS62
AILE66
ALEU67
AASP83
ACYS84

site_idAC2
Number of Residues6
Detailsbinding site for residue TRS A 402
ChainResidue
AASP169
AGLN171
ATYR172
AASP202
ATHR203
AGLN208

site_idAC3
Number of Residues4
Detailsbinding site for residue GOL B 401
ChainResidue
BHIS102
BLEU103
BGLY104
BGLU171

site_idAC4
Number of Residues18
Detailsbinding site for residue SAH C 401
ChainResidue
CTYR22
CHIS28
CARG37
CGLY61
CCYS62
CTHR64
CILE66
CLEU67
CASP83
CCYS84
CSER85
CGLY109
CLYS110
CVAL111
CGLU112
CMSE137
CTHR140
CHOH515

site_idAC5
Number of Residues5
Detailsbinding site for residue TRS C 402
ChainResidue
CASP169
CTYR172
CASP202
CTHR203
CGLN208

site_idAC6
Number of Residues4
Detailsbinding site for residue GOL D 401
ChainResidue
DASP214
DPHE217
DARG248
DHOH510

247947

PDB entries from 2026-01-21

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