6DNF
Cryo-EM structure of the mitochondrial calcium uniporter MCU from the fungus Cyphellophora europaea
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0015292 | molecular_function | uniporter activity |
| A | 0036444 | biological_process | calcium import into the mitochondrion |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| A | 1990246 | cellular_component | uniplex complex |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0015292 | molecular_function | uniporter activity |
| B | 0036444 | biological_process | calcium import into the mitochondrion |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| B | 1990246 | cellular_component | uniplex complex |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0005743 | cellular_component | mitochondrial inner membrane |
| C | 0015292 | molecular_function | uniporter activity |
| C | 0036444 | biological_process | calcium import into the mitochondrion |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0051289 | biological_process | protein homotetramerization |
| C | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| C | 1990246 | cellular_component | uniplex complex |
| D | 0005262 | molecular_function | calcium channel activity |
| D | 0005743 | cellular_component | mitochondrial inner membrane |
| D | 0015292 | molecular_function | uniporter activity |
| D | 0036444 | biological_process | calcium import into the mitochondrion |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0051289 | biological_process | protein homotetramerization |
| D | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| D | 1990246 | cellular_component | uniplex complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 403 |
| Chain | Residue |
| A | GLU228 |
| B | GLU228 |
| C | GLU228 |
| D | GLU228 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue DGG B 402 |
| Chain | Residue |
| B | TYR232 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue DGG B 403 |
| Chain | Residue |
| B | LEU233 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue DGG D 501 |
| Chain | Residue |
| D | TYR232 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue DGG D 502 |
| Chain | Residue |
| D | LEU233 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 164 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29995857","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DNF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"29995857","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"29995857","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29995857","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
