6DNF

Cryo-EM structure of the mitochondrial calcium uniporter MCU from the fungus Cyphellophora europaea

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005262	molecular_function	calcium channel activity
A	0005743	cellular_component	mitochondrial inner membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0015292	molecular_function	uniporter activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0036444	biological_process	calcium import into the mitochondrion
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051289	biological_process	protein homotetramerization
A	0051560	biological_process	mitochondrial calcium ion homeostasis
A	0070588	biological_process	calcium ion transmembrane transport
A	1990246	cellular_component	uniplex complex
B	0005262	molecular_function	calcium channel activity
B	0005743	cellular_component	mitochondrial inner membrane
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0015292	molecular_function	uniporter activity
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0036444	biological_process	calcium import into the mitochondrion
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051289	biological_process	protein homotetramerization
B	0051560	biological_process	mitochondrial calcium ion homeostasis
B	0070588	biological_process	calcium ion transmembrane transport
B	1990246	cellular_component	uniplex complex
C	0005262	molecular_function	calcium channel activity
C	0005743	cellular_component	mitochondrial inner membrane
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0015292	molecular_function	uniporter activity
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0036444	biological_process	calcium import into the mitochondrion
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051289	biological_process	protein homotetramerization
C	0051560	biological_process	mitochondrial calcium ion homeostasis
C	0070588	biological_process	calcium ion transmembrane transport
C	1990246	cellular_component	uniplex complex
D	0005262	molecular_function	calcium channel activity
D	0005743	cellular_component	mitochondrial inner membrane
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0015292	molecular_function	uniporter activity
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0036444	biological_process	calcium import into the mitochondrion
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051289	biological_process	protein homotetramerization
D	0051560	biological_process	mitochondrial calcium ion homeostasis
D	0070588	biological_process	calcium ion transmembrane transport
D	1990246	cellular_component	uniplex complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CA A 403

Chain	Residue
A	GLU228
B	GLU228
C	GLU228
D	GLU228

---

site_id	AC2
Number of Residues	1
Details	binding site for residue DGG B 402

Chain	Residue
B	TYR232

---

site_id	AC3
Number of Residues	1
Details	binding site for residue DGG B 403

Chain	Residue
B	LEU233

---

site_id	AC4
Number of Residues	1
Details	binding site for residue DGG D 501

Chain	Residue
D	TYR232

---

site_id	AC5
Number of Residues	1
Details	binding site for residue DGG D 502

Chain	Residue
D	LEU233

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	164
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29995857","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DNF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	36
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"29995857","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"29995857","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29995857","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---