6DMM

Crystal structure of the G23A mutant of human alpha defensin HNP4.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0006952	biological_process	defense response
B	0005576	cellular_component	extracellular region
B	0006952	biological_process	defense response
C	0005576	cellular_component	extracellular region
C	0006952	biological_process	defense response
D	0005576	cellular_component	extracellular region
D	0006952	biological_process	defense response
E	0005576	cellular_component	extracellular region
E	0006952	biological_process	defense response
F	0005576	cellular_component	extracellular region
F	0006952	biological_process	defense response
G	0005576	cellular_component	extracellular region
G	0006952	biological_process	defense response
H	0005576	cellular_component	extracellular region
H	0006952	biological_process	defense response
I	0005576	cellular_component	extracellular region
I	0006952	biological_process	defense response
J	0005576	cellular_component	extracellular region
J	0006952	biological_process	defense response
K	0005576	cellular_component	extracellular region
K	0006952	biological_process	defense response
L	0005576	cellular_component	extracellular region
L	0006952	biological_process	defense response

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue SO4 A 101

Chain	Residue
A	ARG10
A	ARG11

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 B 101

Chain	Residue
A	ARG32
B	ARG10
B	ARG11
B	HOH206
K	ARG15

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MPD B 102

Chain	Residue
E	PHE26
H	VAL24
B	PHE26
E	LEU6

---

site_id	AC4
Number of Residues	8
Details	binding site for residue SO4 D 101

Chain	Residue
A	ARG5
A	ARG10
A	GLU13
D	ARG15
D	ASN18
D	HOH203
D	HOH215
I	VAL1

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 D 102

Chain	Residue
D	ARG10
D	ARG11
E	ARG32
I	ARG15

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 E 101

Chain	Residue
E	VAL1
H	ASN18
H	HOH201
K	ARG10

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 F 101

Chain	Residue
C	ARG32
F	ARG10
F	ARG11

---

site_id	AC8
Number of Residues	6
Details	binding site for residue SO4 G 101

Chain	Residue
C	VAL1
G	ARG5
G	ARG10
G	HOH203
J	ASN18
J	HOH201

---

site_id	AC9
Number of Residues	7
Details	binding site for residue SO4 G 102

Chain	Residue
C	ARG5
C	ARG10
F	ASN18
F	SER25
F	THR27
F	HOH201
G	ARG11

---

site_id	AD1
Number of Residues	8
Details	binding site for residue SO4 H 101

Chain	Residue
A	HOH203
H	ARG15
H	ASN18
H	THR27
H	HOH205
H	HOH207
K	ARG10
K	HOH211

---

site_id	AD2
Number of Residues	9
Details	binding site for residue SO4 H 102

Chain	Residue
D	ARG10
H	VAL1
H	THR31
H	HOH220
H	HOH221
I	ARG15
I	ASN18
I	HOH212
J	HOH216

---

site_id	AD3
Number of Residues	2
Details	binding site for residue SO4 H 103

Chain	Residue
H	ARG5
H	ARG10

---

site_id	AD4
Number of Residues	6
Details	binding site for residue SO4 I 101

Chain	Residue
A	VAL1
A	THR31
I	ARG5
I	ARG10
L	ASN18
L	HOH207

---

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 J 101

Chain	Residue
C	ARG15
J	ARG10
J	ARG11

---

site_id	AD6
Number of Residues	9
Details	binding site for residue SO4 J 102

Chain	Residue
G	ARG10
J	ARG15
J	ASN18
J	THR27
J	HOH206
J	HOH207
J	HOH209
J	HOH217
J	HOH223

---

site_id	AD7
Number of Residues	3
Details	binding site for residue SO4 J 103

Chain	Residue
B	VAL1
J	ARG5
J	ARG10

---

site_id	AD8
Number of Residues	1
Details	binding site for residue MPD J 104

Chain	Residue
J	VAL24

---

site_id	AD9
Number of Residues	8
Details	binding site for residue SO4 K 101

Chain	Residue
B	ARG10
J	VAL1
J	THR31
K	ARG15
K	GLY17
K	ASN18
K	HOH201
K	HOH209

---

site_id	AE1
Number of Residues	6
Details	binding site for residue SO4 L 101

Chain	Residue
F	ARG10
G	ARG15
G	ASN18
L	VAL1
L	THR31
L	HOH226

---

site_id	AE2
Number of Residues	9
Details	binding site for residue SO4 L 102

Chain	Residue
L	ARG15
L	ASN18
L	THR27
L	HOH202
L	HOH212
L	HOH215
L	HOH218
L	HOH219
I	ARG10

---

site_id	AE3
Number of Residues	4
Details	binding site for residue SO4 L 103

Chain	Residue
K	ARG32
L	ARG10
L	ARG11
L	HOH201

---

site_id	AE4
Number of Residues	1
Details	binding site for residue SO4 L 104

Chain	Residue
D	PHE26

---

site_id	AE5
Number of Residues	8
Details	binding site for residue SO4 L 105

Chain	Residue
A	ARG15
A	ASN18
A	THR27
K	ARG32
K	HOH206
L	ARG10
L	HOH205
L	HOH214

---

site_id	AE6
Number of Residues	8
Details	binding site for residue SO4 L 106

Chain	Residue
F	VAL1
F	THR31
F	HOH208
L	ARG5
L	ARG10
L	HOH204
L	HOH216
L	HOH223

---

Functional Information from PROSITE/UniProt

site_id	PS00269
Number of Residues	29
Details	DEFENSIN Mammalian defensins signature. CsCrlvf.CrrtelrvGnCligavsftyCC

Chain	Residue	Details
A	CYS2-CYS30

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Peptide: {"description":"Defensin alpha 4","featureId":"PRO_0000006782","evidences":[{"source":"PubMed","id":"15489334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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