6DL7

Human mitochondrial ClpP in complex with ONC201 (TIC10)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0006508	biological_process	proteolysis
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0006508	biological_process	proteolysis
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue ONC A 301

Chain	Residue
A	LEU79
G	HOH415
A	GLU82
A	HIS116
A	TYR118
A	TRP146
A	LEU170
G	SER108
G	THR135
G	TYR138

---

site_id	AC2
Number of Residues	10
Details	binding site for residue ONC B 301

Chain	Residue
A	LEU104
A	SER108
A	THR135
A	TYR138
A	HOH409
B	LEU79
B	GLU82
B	HIS116
B	TYR118
B	TRP146

---

site_id	AC3
Number of Residues	9
Details	binding site for residue ONC C 301

Chain	Residue
B	LEU104
B	SER108
B	THR135
B	HOH416
C	LEU79
C	GLU82
C	HIS116
C	TYR118
C	TRP146

---

site_id	AC4
Number of Residues	10
Details	binding site for residue ONC D 301

Chain	Residue
C	LEU104
C	SER108
C	THR135
C	TYR138
C	HOH421
D	LEU79
D	GLU82
D	HIS116
D	TYR118
D	TRP146

---

site_id	AC5
Number of Residues	9
Details	binding site for residue ONC E 301

Chain	Residue
D	LEU104
D	SER108
D	THR135
D	TYR138
D	HOH424
E	GLU82
E	HIS116
E	TYR118
E	TRP146

---

site_id	AC6
Number of Residues	11
Details	binding site for residue ONC F 301

Chain	Residue
E	ILE100
E	LEU104
E	SER108
E	THR135
E	HOH424
F	LEU79
F	GLU82
F	HIS116
F	TYR118
F	TRP146
F	VAL148

---

site_id	AC7
Number of Residues	10
Details	binding site for residue ONC G 301

Chain	Residue
F	SER108
F	THR135
F	TYR138
F	HOH426
G	LEU79
G	GLU82
G	HIS116
G	TYR118
G	TRP146
G	VAL148

---

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TwcVGqAASMGS

Chain	Residue	Details
A	THR145-SER156

---

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RhslPnsrIMIHQP

Chain	Residue	Details
A	ARG167-PRO180

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"11923310","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"O88696","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---