6DK0
Human sigma-1 receptor bound to NE-100
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005635 | cellular_component | nuclear envelope |
| A | 0005637 | cellular_component | nuclear inner membrane |
| A | 0005640 | cellular_component | nuclear outer membrane |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006869 | biological_process | lipid transport |
| A | 0007399 | biological_process | nervous system development |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0016020 | cellular_component | membrane |
| A | 0030426 | cellular_component | growth cone |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0038003 | biological_process | G protein-coupled opioid receptor signaling pathway |
| A | 0038023 | molecular_function | signaling receptor activity |
| A | 0042995 | cellular_component | cell projection |
| A | 0043523 | biological_process | regulation of neuron apoptotic process |
| A | 0045202 | cellular_component | synapse |
| A | 0045211 | cellular_component | postsynaptic membrane |
| A | 0070161 | cellular_component | anchoring junction |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0098839 | cellular_component | postsynaptic density membrane |
| B | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005635 | cellular_component | nuclear envelope |
| B | 0005637 | cellular_component | nuclear inner membrane |
| B | 0005640 | cellular_component | nuclear outer membrane |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006869 | biological_process | lipid transport |
| B | 0007399 | biological_process | nervous system development |
| B | 0014069 | cellular_component | postsynaptic density |
| B | 0016020 | cellular_component | membrane |
| B | 0030426 | cellular_component | growth cone |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0038003 | biological_process | G protein-coupled opioid receptor signaling pathway |
| B | 0038023 | molecular_function | signaling receptor activity |
| B | 0042995 | cellular_component | cell projection |
| B | 0043523 | biological_process | regulation of neuron apoptotic process |
| B | 0045202 | cellular_component | synapse |
| B | 0045211 | cellular_component | postsynaptic membrane |
| B | 0070161 | cellular_component | anchoring junction |
| B | 0070207 | biological_process | protein homotrimerization |
| B | 0098839 | cellular_component | postsynaptic density membrane |
| C | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005635 | cellular_component | nuclear envelope |
| C | 0005637 | cellular_component | nuclear inner membrane |
| C | 0005640 | cellular_component | nuclear outer membrane |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0005811 | cellular_component | lipid droplet |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006869 | biological_process | lipid transport |
| C | 0007399 | biological_process | nervous system development |
| C | 0014069 | cellular_component | postsynaptic density |
| C | 0016020 | cellular_component | membrane |
| C | 0030426 | cellular_component | growth cone |
| C | 0031410 | cellular_component | cytoplasmic vesicle |
| C | 0038003 | biological_process | G protein-coupled opioid receptor signaling pathway |
| C | 0038023 | molecular_function | signaling receptor activity |
| C | 0042995 | cellular_component | cell projection |
| C | 0043523 | biological_process | regulation of neuron apoptotic process |
| C | 0045202 | cellular_component | synapse |
| C | 0045211 | cellular_component | postsynaptic membrane |
| C | 0070161 | cellular_component | anchoring junction |
| C | 0070207 | biological_process | protein homotrimerization |
| C | 0098839 | cellular_component | postsynaptic density membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue GKY A 301 |
| Chain | Residue |
| A | VAL84 |
| A | TRP164 |
| A | MET170 |
| A | GLU172 |
| A | THR181 |
| A | ALA185 |
| A | TYR206 |
| A | TYR103 |
| A | PHE107 |
| A | SER117 |
| A | TYR120 |
| A | ILE124 |
| A | ASP126 |
| A | PHE133 |
| A | HIS154 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | ARG208 |
| A | ARG211 |
| A | HOH404 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | GLN38 |
| A | ARG39 |
| A | ARG175 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 304 |
| Chain | Residue |
| A | ASP53 |
| A | HIS54 |
| A | ASN167 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | ARG204 |
| A | HOH403 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | ARG60 |
| C | SER130 |
| C | GLY131 |
| C | PRO148 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 A 307 |
| Chain | Residue |
| A | ARG137 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 308 |
| Chain | Residue |
| A | LEU79 |
| A | TRP81 |
| A | CYS94 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 309 |
| Chain | Residue |
| A | LEU30 |
| A | LEU100 |
| A | VAL177 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue OLC A 310 |
| Chain | Residue |
| A | ARG119 |
| A | TRP121 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 311 |
| Chain | Residue |
| A | ARG39 |
| A | ARG175 |
| C | GLN221 |
| site_id | AD3 |
| Number of Residues | 14 |
| Details | binding site for residue GKY B 301 |
| Chain | Residue |
| B | MET93 |
| B | LEU95 |
| B | TYR103 |
| B | SER117 |
| B | TYR120 |
| B | ASP126 |
| B | PHE133 |
| B | HIS154 |
| B | TRP164 |
| B | GLU172 |
| B | ILE178 |
| B | THR181 |
| B | ALA185 |
| B | TYR206 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | ARG208 |
| B | ARG211 |
| B | HOH406 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| B | ARG204 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 304 |
| Chain | Residue |
| B | ARG39 |
| B | ARG175 |
| B | HOH405 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 305 |
| Chain | Residue |
| B | ASP53 |
| B | HIS54 |
| B | SER130 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 306 |
| Chain | Residue |
| A | ARG114 |
| B | ARG114 |
| B | HOH403 |
| B | HOH404 |
| C | ARG114 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue GOL B 307 |
| Chain | Residue |
| B | TRP81 |
| site_id | AE1 |
| Number of Residues | 15 |
| Details | binding site for residue GKY C 301 |
| Chain | Residue |
| C | VAL84 |
| C | MET93 |
| C | LEU95 |
| C | TYR103 |
| C | LEU105 |
| C | TYR120 |
| C | ILE124 |
| C | HIS154 |
| C | VAL162 |
| C | TRP164 |
| C | GLU172 |
| C | LEU182 |
| C | ALA185 |
| C | THR202 |
| C | TYR206 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 302 |
| Chain | Residue |
| C | ARG208 |
| C | ARG211 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 303 |
| Chain | Residue |
| C | ARG39 |
| C | ARG175 |
| C | HOH418 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 304 |
| Chain | Residue |
| C | ARG204 |
| C | ARG204 |
| C | HOH402 |
| C | HOH402 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue GOL C 305 |
| Chain | Residue |
| C | TRP81 |
| C | HOH412 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue OLC C 306 |
| Chain | Residue |
| C | GLN33 |
| C | LEU100 |
| C | SER101 |
| C | GLY176 |
| C | VAL177 |
| C | OLC307 |
| C | TRP29 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue OLC C 307 |
| Chain | Residue |
| A | TRP27 |
| C | TRP29 |
| C | OLC306 |
| C | OLC309 |
| site_id | AE8 |
| Number of Residues | 1 |
| Details | binding site for residue OLC C 308 |
| Chain | Residue |
| C | GLU213 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue OLC C 309 |
| Chain | Residue |
| A | GLN24 |
| A | TRP27 |
| B | ARG7 |
| C | TRP29 |
| C | THR32 |
| C | OLC307 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue OLC C 310 |
| Chain | Residue |
| C | GLU123 |
| C | PRO156 |
| C | ARG175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | TOPO_DOM: Lumenal => ECO:0000305|PubMed:27042935 |
| Chain | Residue | Details |
| A | MET1-TRP9 | |
| B | MET1-TRP9 | |
| C | MET1-TRP9 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:27042935 |
| Chain | Residue | Details |
| A | ALA10-LEU30 | |
| B | ALA10-LEU30 | |
| C | ALA10-LEU30 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 576 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:27042935 |
| Chain | Residue | Details |
| A | GLY31-PRO223 | |
| B | GLY31-PRO223 | |
| C | GLY31-PRO223 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | SITE: Important for ligand binding => ECO:0000269|PubMed:11476895 |
| Chain | Residue | Details |
| A | ASP126 | |
| A | GLU172 | |
| B | ASP126 | |
| B | GLU172 | |
| C | ASP126 | |
| C | GLU172 |
