6DJL

Crystal structure of the Rab11 GEF SH3BP5 bound to nucleotide free Rab11A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0000281	biological_process	mitotic cytokinesis
A	0000922	cellular_component	spindle pole
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005771	cellular_component	multivesicular body
A	0005794	cellular_component	Golgi apparatus
A	0005802	cellular_component	trans-Golgi network
A	0005813	cellular_component	centrosome
A	0005814	cellular_component	centriole
A	0005828	cellular_component	kinetochore microtubule
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006887	biological_process	exocytosis
A	0006904	biological_process	vesicle docking involved in exocytosis
A	0007018	biological_process	microtubule-based movement
A	0007080	biological_process	mitotic metaphase chromosome alignment
A	0008017	molecular_function	microtubule binding
A	0010008	cellular_component	endosome membrane
A	0010634	biological_process	positive regulation of epithelial cell migration
A	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016192	biological_process	vesicle-mediated transport
A	0016787	molecular_function	hydrolase activity
A	0019905	molecular_function	syntaxin binding
A	0030133	cellular_component	transport vesicle
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0030666	cellular_component	endocytic vesicle membrane
A	0030672	cellular_component	synaptic vesicle membrane
A	0030953	biological_process	astral microtubule organization
A	0031175	biological_process	neuron projection development
A	0031410	cellular_component	cytoplasmic vesicle
A	0031489	molecular_function	myosin V binding
A	0031982	cellular_component	vesicle
A	0032154	cellular_component	cleavage furrow
A	0032402	biological_process	melanosome transport
A	0032465	biological_process	regulation of cytokinesis
A	0032588	cellular_component	trans-Golgi network membrane
A	0032991	cellular_component	protein-containing complex
A	0034394	biological_process	protein localization to cell surface
A	0036258	biological_process	multivesicular body assembly
A	0043001	biological_process	Golgi to plasma membrane protein transport
A	0045335	cellular_component	phagocytic vesicle
A	0045724	biological_process	positive regulation of cilium assembly
A	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
A	0048227	biological_process	plasma membrane to endosome transport
A	0051223	biological_process	regulation of protein transport
A	0051650	biological_process	establishment of vesicle localization
A	0051959	molecular_function	dynein light intermediate chain binding
A	0055037	cellular_component	recycling endosome
A	0055038	cellular_component	recycling endosome membrane
A	0060627	biological_process	regulation of vesicle-mediated transport
A	0061502	biological_process	early endosome to recycling endosome transport
A	0061512	biological_process	protein localization to cilium
A	0070062	cellular_component	extracellular exosome
A	0071806	biological_process	protein transmembrane transport
A	0072594	biological_process	establishment of protein localization to organelle
A	0072659	biological_process	protein localization to plasma membrane
A	0090150	biological_process	establishment of protein localization to membrane
A	0090307	biological_process	mitotic spindle assembly
A	0098685	cellular_component	Schaffer collateral - CA1 synapse
A	0098830	cellular_component	presynaptic endosome
A	0098837	cellular_component	postsynaptic recycling endosome
A	0098876	biological_process	vesicle-mediated transport to the plasma membrane
A	0098887	biological_process	neurotransmitter receptor transport, endosome to postsynaptic membrane
A	0098978	cellular_component	glutamatergic synapse
A	0099003	biological_process	vesicle-mediated transport in synapse
A	0099532	biological_process	synaptic vesicle endosomal processing
A	0150093	biological_process	amyloid-beta clearance by transcytosis
A	1902017	biological_process	regulation of cilium assembly
A	1902954	biological_process	regulation of early endosome to recycling endosome transport
A	1903078	biological_process	positive regulation of protein localization to plasma membrane
A	1903438	biological_process	positive regulation of mitotic cytokinetic process
A	1904779	biological_process	regulation of protein localization to centrosome
A	1905345	biological_process	protein localization to cleavage furrow
A	1990182	biological_process	exosomal secretion
A	2001135	biological_process	regulation of endocytic recycling
B	0035556	biological_process	intracellular signal transduction
C	0035556	biological_process	intracellular signal transduction
D	0035556	biological_process	intracellular signal transduction
E	0035556	biological_process	intracellular signal transduction
F	0000139	cellular_component	Golgi membrane
F	0000166	molecular_function	nucleotide binding
F	0000281	biological_process	mitotic cytokinesis
F	0000922	cellular_component	spindle pole
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005768	cellular_component	endosome
F	0005771	cellular_component	multivesicular body
F	0005794	cellular_component	Golgi apparatus
F	0005802	cellular_component	trans-Golgi network
F	0005813	cellular_component	centrosome
F	0005814	cellular_component	centriole
F	0005828	cellular_component	kinetochore microtubule
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006887	biological_process	exocytosis
F	0006904	biological_process	vesicle docking involved in exocytosis
F	0007018	biological_process	microtubule-based movement
F	0007080	biological_process	mitotic metaphase chromosome alignment
F	0008017	molecular_function	microtubule binding
F	0010008	cellular_component	endosome membrane
F	0010634	biological_process	positive regulation of epithelial cell migration
F	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
F	0015031	biological_process	protein transport
F	0016020	cellular_component	membrane
F	0016192	biological_process	vesicle-mediated transport
F	0016787	molecular_function	hydrolase activity
F	0019905	molecular_function	syntaxin binding
F	0030133	cellular_component	transport vesicle
F	0030659	cellular_component	cytoplasmic vesicle membrane
F	0030666	cellular_component	endocytic vesicle membrane
F	0030672	cellular_component	synaptic vesicle membrane
F	0030953	biological_process	astral microtubule organization
F	0031175	biological_process	neuron projection development
F	0031410	cellular_component	cytoplasmic vesicle
F	0031489	molecular_function	myosin V binding
F	0031982	cellular_component	vesicle
F	0032154	cellular_component	cleavage furrow
F	0032402	biological_process	melanosome transport
F	0032465	biological_process	regulation of cytokinesis
F	0032588	cellular_component	trans-Golgi network membrane
F	0032991	cellular_component	protein-containing complex
F	0034394	biological_process	protein localization to cell surface
F	0036258	biological_process	multivesicular body assembly
F	0043001	biological_process	Golgi to plasma membrane protein transport
F	0045335	cellular_component	phagocytic vesicle
F	0045724	biological_process	positive regulation of cilium assembly
F	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
F	0048227	biological_process	plasma membrane to endosome transport
F	0051223	biological_process	regulation of protein transport
F	0051650	biological_process	establishment of vesicle localization
F	0051959	molecular_function	dynein light intermediate chain binding
F	0055037	cellular_component	recycling endosome
F	0055038	cellular_component	recycling endosome membrane
F	0060627	biological_process	regulation of vesicle-mediated transport
F	0061502	biological_process	early endosome to recycling endosome transport
F	0061512	biological_process	protein localization to cilium
F	0070062	cellular_component	extracellular exosome
F	0071806	biological_process	protein transmembrane transport
F	0072594	biological_process	establishment of protein localization to organelle
F	0072659	biological_process	protein localization to plasma membrane
F	0090150	biological_process	establishment of protein localization to membrane
F	0090307	biological_process	mitotic spindle assembly
F	0098685	cellular_component	Schaffer collateral - CA1 synapse
F	0098830	cellular_component	presynaptic endosome
F	0098837	cellular_component	postsynaptic recycling endosome
F	0098876	biological_process	vesicle-mediated transport to the plasma membrane
F	0098887	biological_process	neurotransmitter receptor transport, endosome to postsynaptic membrane
F	0098978	cellular_component	glutamatergic synapse
F	0099003	biological_process	vesicle-mediated transport in synapse
F	0099532	biological_process	synaptic vesicle endosomal processing
F	0150093	biological_process	amyloid-beta clearance by transcytosis
F	1902017	biological_process	regulation of cilium assembly
F	1902954	biological_process	regulation of early endosome to recycling endosome transport
F	1903078	biological_process	positive regulation of protein localization to plasma membrane
F	1903438	biological_process	positive regulation of mitotic cytokinetic process
F	1904779	biological_process	regulation of protein localization to centrosome
F	1905345	biological_process	protein localization to cleavage furrow
F	1990182	biological_process	exosomal secretion
F	2001135	biological_process	regulation of endocytic recycling
G	0000139	cellular_component	Golgi membrane
G	0000166	molecular_function	nucleotide binding
G	0000281	biological_process	mitotic cytokinesis
G	0000922	cellular_component	spindle pole
G	0003924	molecular_function	GTPase activity
G	0003925	molecular_function	G protein activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005768	cellular_component	endosome
G	0005771	cellular_component	multivesicular body
G	0005794	cellular_component	Golgi apparatus
G	0005802	cellular_component	trans-Golgi network
G	0005813	cellular_component	centrosome
G	0005814	cellular_component	centriole
G	0005828	cellular_component	kinetochore microtubule
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006887	biological_process	exocytosis
G	0006904	biological_process	vesicle docking involved in exocytosis
G	0007018	biological_process	microtubule-based movement
G	0007080	biological_process	mitotic metaphase chromosome alignment
G	0008017	molecular_function	microtubule binding
G	0010008	cellular_component	endosome membrane
G	0010634	biological_process	positive regulation of epithelial cell migration
G	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
G	0015031	biological_process	protein transport
G	0016020	cellular_component	membrane
G	0016192	biological_process	vesicle-mediated transport
G	0016787	molecular_function	hydrolase activity
G	0019905	molecular_function	syntaxin binding
G	0030133	cellular_component	transport vesicle
G	0030659	cellular_component	cytoplasmic vesicle membrane
G	0030666	cellular_component	endocytic vesicle membrane
G	0030672	cellular_component	synaptic vesicle membrane
G	0030953	biological_process	astral microtubule organization
G	0031175	biological_process	neuron projection development
G	0031410	cellular_component	cytoplasmic vesicle
G	0031489	molecular_function	myosin V binding
G	0031982	cellular_component	vesicle
G	0032154	cellular_component	cleavage furrow
G	0032402	biological_process	melanosome transport
G	0032465	biological_process	regulation of cytokinesis
G	0032588	cellular_component	trans-Golgi network membrane
G	0032991	cellular_component	protein-containing complex
G	0034394	biological_process	protein localization to cell surface
G	0036258	biological_process	multivesicular body assembly
G	0043001	biological_process	Golgi to plasma membrane protein transport
G	0045335	cellular_component	phagocytic vesicle
G	0045724	biological_process	positive regulation of cilium assembly
G	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
G	0048227	biological_process	plasma membrane to endosome transport
G	0051223	biological_process	regulation of protein transport
G	0051650	biological_process	establishment of vesicle localization
G	0051959	molecular_function	dynein light intermediate chain binding
G	0055037	cellular_component	recycling endosome
G	0055038	cellular_component	recycling endosome membrane
G	0060627	biological_process	regulation of vesicle-mediated transport
G	0061502	biological_process	early endosome to recycling endosome transport
G	0061512	biological_process	protein localization to cilium
G	0070062	cellular_component	extracellular exosome
G	0071806	biological_process	protein transmembrane transport
G	0072594	biological_process	establishment of protein localization to organelle
G	0072659	biological_process	protein localization to plasma membrane
G	0090150	biological_process	establishment of protein localization to membrane
G	0090307	biological_process	mitotic spindle assembly
G	0098685	cellular_component	Schaffer collateral - CA1 synapse
G	0098830	cellular_component	presynaptic endosome
G	0098837	cellular_component	postsynaptic recycling endosome
G	0098876	biological_process	vesicle-mediated transport to the plasma membrane
G	0098887	biological_process	neurotransmitter receptor transport, endosome to postsynaptic membrane
G	0098978	cellular_component	glutamatergic synapse
G	0099003	biological_process	vesicle-mediated transport in synapse
G	0099532	biological_process	synaptic vesicle endosomal processing
G	0150093	biological_process	amyloid-beta clearance by transcytosis
G	1902017	biological_process	regulation of cilium assembly
G	1902954	biological_process	regulation of early endosome to recycling endosome transport
G	1903078	biological_process	positive regulation of protein localization to plasma membrane
G	1903438	biological_process	positive regulation of mitotic cytokinetic process
G	1904779	biological_process	regulation of protein localization to centrosome
G	1905345	biological_process	protein localization to cleavage furrow
G	1990182	biological_process	exosomal secretion
G	2001135	biological_process	regulation of endocytic recycling
H	0000139	cellular_component	Golgi membrane
H	0000166	molecular_function	nucleotide binding
H	0000281	biological_process	mitotic cytokinesis
H	0000922	cellular_component	spindle pole
H	0003924	molecular_function	GTPase activity
H	0003925	molecular_function	G protein activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005768	cellular_component	endosome
H	0005771	cellular_component	multivesicular body
H	0005794	cellular_component	Golgi apparatus
H	0005802	cellular_component	trans-Golgi network
H	0005813	cellular_component	centrosome
H	0005814	cellular_component	centriole
H	0005828	cellular_component	kinetochore microtubule
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006887	biological_process	exocytosis
H	0006904	biological_process	vesicle docking involved in exocytosis
H	0007018	biological_process	microtubule-based movement
H	0007080	biological_process	mitotic metaphase chromosome alignment
H	0008017	molecular_function	microtubule binding
H	0010008	cellular_component	endosome membrane
H	0010634	biological_process	positive regulation of epithelial cell migration
H	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
H	0015031	biological_process	protein transport
H	0016020	cellular_component	membrane
H	0016192	biological_process	vesicle-mediated transport
H	0016787	molecular_function	hydrolase activity
H	0019905	molecular_function	syntaxin binding
H	0030133	cellular_component	transport vesicle
H	0030659	cellular_component	cytoplasmic vesicle membrane
H	0030666	cellular_component	endocytic vesicle membrane
H	0030672	cellular_component	synaptic vesicle membrane
H	0030953	biological_process	astral microtubule organization
H	0031175	biological_process	neuron projection development
H	0031410	cellular_component	cytoplasmic vesicle
H	0031489	molecular_function	myosin V binding
H	0031982	cellular_component	vesicle
H	0032154	cellular_component	cleavage furrow
H	0032402	biological_process	melanosome transport
H	0032465	biological_process	regulation of cytokinesis
H	0032588	cellular_component	trans-Golgi network membrane
H	0032991	cellular_component	protein-containing complex
H	0034394	biological_process	protein localization to cell surface
H	0036258	biological_process	multivesicular body assembly
H	0043001	biological_process	Golgi to plasma membrane protein transport
H	0045335	cellular_component	phagocytic vesicle
H	0045724	biological_process	positive regulation of cilium assembly
H	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
H	0048227	biological_process	plasma membrane to endosome transport
H	0051223	biological_process	regulation of protein transport
H	0051650	biological_process	establishment of vesicle localization
H	0051959	molecular_function	dynein light intermediate chain binding
H	0055037	cellular_component	recycling endosome
H	0055038	cellular_component	recycling endosome membrane
H	0060627	biological_process	regulation of vesicle-mediated transport
H	0061502	biological_process	early endosome to recycling endosome transport
H	0061512	biological_process	protein localization to cilium
H	0070062	cellular_component	extracellular exosome
H	0071806	biological_process	protein transmembrane transport
H	0072594	biological_process	establishment of protein localization to organelle
H	0072659	biological_process	protein localization to plasma membrane
H	0090150	biological_process	establishment of protein localization to membrane
H	0090307	biological_process	mitotic spindle assembly
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098830	cellular_component	presynaptic endosome
H	0098837	cellular_component	postsynaptic recycling endosome
H	0098876	biological_process	vesicle-mediated transport to the plasma membrane
H	0098887	biological_process	neurotransmitter receptor transport, endosome to postsynaptic membrane
H	0098978	cellular_component	glutamatergic synapse
H	0099003	biological_process	vesicle-mediated transport in synapse
H	0099532	biological_process	synaptic vesicle endosomal processing
H	0150093	biological_process	amyloid-beta clearance by transcytosis
H	1902017	biological_process	regulation of cilium assembly
H	1902954	biological_process	regulation of early endosome to recycling endosome transport
H	1903078	biological_process	positive regulation of protein localization to plasma membrane
H	1903438	biological_process	positive regulation of mitotic cytokinetic process
H	1904779	biological_process	regulation of protein localization to centrosome
H	1905345	biological_process	protein localization to cleavage furrow
H	1990182	biological_process	exosomal secretion
H	2001135	biological_process	regulation of endocytic recycling

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VVLiGDSGVGKsnL

Chain	Residue	Details
A	VAL14-LEU27

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17030804, ECO:0007744|PDB:2D7C, ECO:0007744|PDB:2GZD, ECO:0007744|PDB:2GZH

Chain	Residue	Details
A	SER20
F	SER20
G	SER20
H	SER20

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17007872, ECO:0000269|PubMed:17030804, ECO:0007744|PDB:2D7C, ECO:0007744|PDB:2GZD, ECO:0007744|PDB:2GZH, ECO:0007744|PDB:2HV8

Chain	Residue	Details
A	GLY21
A	ASP127
A	ALA155
A	LEU156
F	GLY21
F	GLY23
F	LYS24
F	ASN26
F	ASN37
F	LEU38
F	SER40
A	GLY23
F	GLY69
F	LYS125
F	ASP127
F	ALA155
F	LEU156
G	GLY21
G	GLY23
G	LYS24
G	ASN26
G	ASN37
A	LYS24
G	LEU38
G	SER40
G	GLY69
G	LYS125
G	ASP127
G	ALA155
G	LEU156
H	GLY21
H	GLY23
H	LYS24
A	ASN26
H	ASN26
H	ASN37
H	LEU38
H	SER40
H	GLY69
H	LYS125
H	ASP127
H	ALA155
H	LEU156
A	ASN37
A	LEU38
A	SER40
A	GLY69
A	LYS125

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16905101, ECO:0007744|PDB:2GZH

Chain	Residue	Details
A	VAL22
F	VAL22
G	VAL22
H	VAL22

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:15837192, ECO:0000269|PubMed:16034420, ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17007872, ECO:0000269|PubMed:17030804, ECO:0007744|PDB:1OIX, ECO:0007744|PDB:1YZK, ECO:0007744|PDB:2D7C, ECO:0007744|PDB:2GZD, ECO:0007744|PDB:2GZH, ECO:0007744|PDB:2HV8

Chain	Residue	Details
A	SER25
A	THR43
F	SER25
F	THR43
G	SER25
G	THR43
H	SER25
H	THR43

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17007872, ECO:0000269|PubMed:17030804, ECO:0007744|PDB:2GZD, ECO:0007744|PDB:2GZH

Chain	Residue	Details
A	SER42
F	SER42
G	SER42
H	SER42

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17030804, ECO:0007744|PDB:2D7C, ECO:0007744|PDB:2GZD

Chain	Residue	Details
A	ASP66
F	ASP66
G	ASP66
H	ASP66

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17007872, ECO:0000269|PubMed:17030804, ECO:0007744|PDB:2D7C, ECO:0007744|PDB:2GZD, ECO:0007744|PDB:2GZH

Chain	Residue	Details
A	ASN124
F	ASN124
G	ASN124
H	ASN124

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N-acetylglycine => ECO:0000269|Ref.11

Chain	Residue	Details
A	GLY2
F	GLY2
G	GLY2
H	GLY2

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Cysteine methyl ester => ECO:0000255

Chain	Residue	Details
A	CYS213
F	CYS213
G	CYS213
H	CYS213

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	LIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:24023390

Chain	Residue	Details
A	CYS212
A	CYS213
F	CYS212
F	CYS213
G	CYS212
G	CYS213
H	CYS212
H	CYS213

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	CARBOHYD: (Microbial infection) N-beta-linked (GlcNAc) arginine => ECO:0000269|PubMed:32974215

Chain	Residue	Details
A	ARG4
F	ARG4
G	ARG4
H	ARG4

---