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6DHA

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Hydroxy Pioglitazone (M-IV)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue GFV A 501
ChainResidue
AILE281
AILE341
AMET364
AHIS449
ATYR473
AHOH628
APHE282
AGLY284
ACYS285
AGLN286
ASER289
AHIS323
ATYR327
ALEU330

site_idAC2
Number of Residues12
Detailsbinding site for residue KNA A 502
ChainResidue
ALEU228
AARG288
AMET329
ALEU330
ALEU333
ASER342
AGLU343
AHOH608
AHOH622
AHOH624
AHOH628
AHOH662

site_idAC3
Number of Residues2
Detailsbinding site for residue KNA A 503
ChainResidue
AGLY258
AHOH620

site_idAC4
Number of Residues15
Detailsbinding site for residue GFV B 501
ChainResidue
BILE249
BLEU255
BGLU259
BPHE264
BHIS266
BILE267
BARG280
BILE281
BCYS285
BARG288
BALA292
BILE326
BLEU330
BILE341
BMET348

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
ChainResidueDetails
AGLN286
AHIS323
AHIS449
ATYR473
BGLN286
BHIS323
BHIS449
BTYR473

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
ALYS224
BLYS224

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PDB entries from 2024-11-06

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