6DGD
PriA helicase bound to dsDNA of a DNA replication fork
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003678 | molecular_function | DNA helicase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006260 | biological_process | DNA replication |
| A | 0006269 | biological_process | DNA replication, synthesis of primer |
| A | 0006270 | biological_process | DNA replication initiation |
| A | 0006302 | biological_process | double-strand break repair |
| A | 0006310 | biological_process | DNA recombination |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1990077 | cellular_component | primosome complex |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003678 | molecular_function | DNA helicase activity |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006260 | biological_process | DNA replication |
| B | 0006269 | biological_process | DNA replication, synthesis of primer |
| B | 0006270 | biological_process | DNA replication initiation |
| B | 0006302 | biological_process | double-strand break repair |
| B | 0006310 | biological_process | DNA recombination |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1990077 | cellular_component | primosome complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | CYS444 |
| A | CYS447 |
| A | CYS462 |
| A | CYS465 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 802 |
| Chain | Residue |
| A | CYS435 |
| A | CYS438 |
| A | CYS475 |
| A | CYS478 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 803 |
| Chain | Residue |
| A | LYS543 |
| A | GLN579 |
| A | ARG583 |
| A | THR225 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 804 |
| Chain | Residue |
| A | GLY331 |
| A | ARG333 |
| A | VAL723 |
| A | SO4805 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 805 |
| Chain | Residue |
| A | ARG333 |
| A | ARG687 |
| A | SO4804 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 806 |
| Chain | Residue |
| A | HIS97 |
| A | ARG104 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 807 |
| Chain | Residue |
| A | ASN425 |
| A | ARG426 |
| A | PHE429 |
| A | SER569 |
| A | ARG572 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 808 |
| Chain | Residue |
| A | GLY226 |
| A | SER227 |
| A | GLY228 |
| A | LYS229 |
| A | THR230 |
| A | LYS543 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 809 |
| Chain | Residue |
| A | LYS370 |
| A | ARG697 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 810 |
| Chain | Residue |
| A | HIS97 |
| A | ARG303 |
| A | SER304 |
| A | GLN328 |
| A | TYR334 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 801 |
| Chain | Residue |
| B | CYS444 |
| B | CYS447 |
| B | CYS462 |
| B | CYS465 |
| B | SER467 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 802 |
| Chain | Residue |
| B | CYS435 |
| B | CYS438 |
| B | CYS475 |
| B | CYS478 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 803 |
| Chain | Residue |
| B | GLU330 |
| B | GLY331 |
| B | ARG333 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 804 |
| Chain | Residue |
| B | ARG333 |
| B | ARG682 |
| B | ARG687 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 805 |
| Chain | Residue |
| B | THR225 |
| B | LYS543 |
| B | GLN579 |
| B | ARG583 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 806 |
| Chain | Residue |
| B | ILE224 |
| B | GLY226 |
| B | SER227 |
| B | GLY228 |
| B | LYS229 |
| B | THR230 |
| B | LYS543 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 807 |
| Chain | Residue |
| B | ASN425 |
| B | ARG426 |
| B | SER569 |
| B | ARG572 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 332 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_00983","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00983","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"4NL4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NL8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DGD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 97 |
| Details | Region: {"description":"3'BD","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 124 |
| Details | Region: {"description":"WH","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 350 |
| Details | Region: {"description":"Helicase lobe 1","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 86 |
| Details | Region: {"description":"Helicase lobe 2, N-terminus","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 108 |
| Details | Region: {"description":"CRR","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Motif: {"description":"DEAH box","evidences":[{"source":"HAMAP-Rule","id":"MF_00983","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 28 |
| Details | Motif: {"description":"Aromatic-rich loop (ARL)","evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00983","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4NL4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24379377","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NL4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
