6DF3

Crystal structure of ternary complex of IL-24 with soluble receptors IL-22RA and IL-20RB

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006915	biological_process	apoptotic process
C	0006955	biological_process	immune response
C	0007165	biological_process	signal transduction
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008285	biological_process	negative regulation of cell population proliferation
C	0030336	biological_process	negative regulation of cell migration
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0071353	biological_process	cellular response to interleukin-4

Functional Information from PROSITE/UniProt

site_id	PS00520
Number of Residues	21
Details	INTERLEUKIN_10 Interleukin-10 family signature. SdaesCYlvhtLLeFYLkTVF

Chain	Residue	Details
C	SER101-PHE121

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	7
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23078624","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	99
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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