Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6DBR

Cryo-EM structure of RAG in complex with one melted RSS and one unmelted RSS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004519	molecular_function	endonuclease activity
A	0005515	molecular_function	protein binding
A	0006974	biological_process	DNA damage response
A	0008643	biological_process	carbohydrate transport
A	0015144	molecular_function	carbohydrate transmembrane transporter activity
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0033151	biological_process	V(D)J recombination
A	0034219	biological_process	carbohydrate transmembrane transport
A	0034289	biological_process	detection of maltose stimulus
A	0042597	cellular_component	periplasmic space
A	0042956	biological_process	maltodextrin transmembrane transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0043565	molecular_function	sequence-specific DNA binding
A	0046872	molecular_function	metal ion binding
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0060326	biological_process	cell chemotaxis
A	0061630	molecular_function	ubiquitin protein ligase activity
A	1901982	molecular_function	maltose binding
A	1990060	cellular_component	maltose transport complex
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0005515	molecular_function	protein binding
B	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
B	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
B	0005634	cellular_component	nucleus
B	0006310	biological_process	DNA recombination
B	0006325	biological_process	chromatin organization
B	0008270	molecular_function	zinc ion binding
B	0030098	biological_process	lymphocyte differentiation
B	0030183	biological_process	B cell differentiation
B	0030217	biological_process	T cell differentiation
B	0033077	biological_process	T cell differentiation in thymus
B	0033151	biological_process	V(D)J recombination
B	0033152	biological_process	immunoglobulin V(D)J recombination
B	0035091	molecular_function	phosphatidylinositol binding
B	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
B	0043565	molecular_function	sequence-specific DNA binding
B	0046872	molecular_function	metal ion binding
B	0048534	biological_process	hematopoietic or lymphoid organ development
B	0048538	biological_process	thymus development
B	0065004	biological_process	protein-DNA complex assembly
B	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
B	0097519	cellular_component	DNA recombinase complex
B	0140002	molecular_function	histone H3K4me3 reader activity
B	1905347	cellular_component	endodeoxyribonuclease complex
B	1990238	molecular_function	double-stranded DNA endonuclease activity
C	0004519	molecular_function	endonuclease activity
C	0005515	molecular_function	protein binding
C	0006974	biological_process	DNA damage response
C	0008643	biological_process	carbohydrate transport
C	0015144	molecular_function	carbohydrate transmembrane transporter activity
C	0015768	biological_process	maltose transport
C	0016020	cellular_component	membrane
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0033151	biological_process	V(D)J recombination
C	0034219	biological_process	carbohydrate transmembrane transport
C	0034289	biological_process	detection of maltose stimulus
C	0042597	cellular_component	periplasmic space
C	0042956	biological_process	maltodextrin transmembrane transport
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0043565	molecular_function	sequence-specific DNA binding
C	0046872	molecular_function	metal ion binding
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	0055085	biological_process	transmembrane transport
C	0060326	biological_process	cell chemotaxis
C	0061630	molecular_function	ubiquitin protein ligase activity
C	1901982	molecular_function	maltose binding
C	1990060	cellular_component	maltose transport complex
D	0003677	molecular_function	DNA binding
D	0003682	molecular_function	chromatin binding
D	0005515	molecular_function	protein binding
D	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
D	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
D	0005634	cellular_component	nucleus
D	0006310	biological_process	DNA recombination
D	0006325	biological_process	chromatin organization
D	0008270	molecular_function	zinc ion binding
D	0030098	biological_process	lymphocyte differentiation
D	0030183	biological_process	B cell differentiation
D	0030217	biological_process	T cell differentiation
D	0033077	biological_process	T cell differentiation in thymus
D	0033151	biological_process	V(D)J recombination
D	0033152	biological_process	immunoglobulin V(D)J recombination
D	0035091	molecular_function	phosphatidylinositol binding
D	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
D	0043565	molecular_function	sequence-specific DNA binding
D	0046872	molecular_function	metal ion binding
D	0048534	biological_process	hematopoietic or lymphoid organ development
D	0048538	biological_process	thymus development
D	0065004	biological_process	protein-DNA complex assembly
D	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
D	0097519	cellular_component	DNA recombinase complex
D	0140002	molecular_function	histone H3K4me3 reader activity
D	1905347	cellular_component	endodeoxyribonuclease complex
D	1990238	molecular_function	double-stranded DNA endonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1101

Chain	Residue
A	CYS749
A	CYS752
A	HIS959
A	HIS964

site_id	AC2
Number of Residues	3
Details	binding site for residue CA A 1102

Chain	Residue
A	ASP620
A	CA1103
F	DA20

site_id	AC3
Number of Residues	4
Details	binding site for residue CA A 1103

Chain	Residue
A	ASP730
A	CA1102
A	ASP620
A	GLU684

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN C 1101

Chain	Residue
C	CYS749
C	CYS752
C	HIS959
C	HIS964

site_id	AC5
Number of Residues	3
Details	binding site for residue CA C 1102

Chain	Residue
C	ASP620
C	GLU984
G	DC17

site_id	AC6
Number of Residues	4
Details	binding site for residue CA C 1103

Chain	Residue
C	ASP620
C	ASP730
G	DA16
G	DC17

Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CrHlFCrlCI

Chain	Residue	Details
A	CYS311-ILE320

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO-9-ASN8

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Essential for DNA hairpin formation, participates in base-stacking interactions near the cleavage site","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)