6DA1

ETS1 in complex with synthetic SRR mimic

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0043565	molecular_function	sequence-specific DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 501

Chain	Residue
A	ARG311
A	LYS316
A	ARG374

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 B 501

Chain	Residue
A	ILE335
A	LYS379
B	ILE335
B	ARG378
B	LYS379
B	HOH603

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 B 502

Chain	Residue
B	ARG311
B	LYS316
B	ARG373
B	ARG374

---

site_id	AC4
Number of Residues	8
Details	binding site for residues SEP C 282 and PF5 C 283

Chain	Residue
B	GLN336
B	TRP338
B	LYS399
B	ILE401
B	LEU421
C	ASP284
C	SEP285
C	PF5286

---

site_id	AC5
Number of Residues	8
Details	binding site for Di-peptide PF5 C 283 and ASP C 284

Chain	Residue
B	GLN336
B	TRP338
B	ILE401
B	LEU421
C	SEP282
C	SEP285
C	PF5286
C	HOH304

---

site_id	AC6
Number of Residues	6
Details	binding site for Di-peptide ASP C 284 and SEP C 285

Chain	Residue
A	LYS381
A	LYS388
C	SEP282
C	PF5283
C	PF5286
C	HOH304

---

site_id	AC7
Number of Residues	12
Details	binding site for residues SEP C 285 and PF5 C 286

Chain	Residue
A	LYS381
A	LYS388
B	GLN336
B	TYR395
B	TYR396
C	PF5283
C	ASP284
C	ASP287
C	PF5288
C	ALA293
C	HOH302
C	HOH304

---

site_id	AC8
Number of Residues	14
Details	binding site for Di-peptide PF5 C 286 and ASP C 287

Chain	Residue
A	LYS381
B	GLN336
B	TYR395
B	TYR396
C	PF5283
C	ASP284
C	SEP285
C	PF5288
C	ALA293
C	LEU295
C	TRP296
C	HOH302
C	HOH308
C	HOH312

---

site_id	AC9
Number of Residues	14
Details	binding site for Di-peptide ASP C 287 and PF5 C 288

Chain	Residue
A	LYS381
A	LYS388
A	ARG391
B	TYR395
C	PF5286
C	GLU289
C	ASP290
C	PF5291
C	ALA293
C	LEU295
C	TRP296
C	HOH308
C	HOH312
C	HOH318

---

site_id	AD1
Number of Residues	16
Details	binding site for Di-peptide PF5 C 288 and GLU C 289

Chain	Residue
A	GLN336
A	LEU337
A	LYS388
A	ARG391
A	TYR396
A	HOH617
B	TYR395
C	PF5286
C	ASP287
C	ASP290
C	PF5291
C	TRP296
C	HOH308
C	HOH310
C	HOH313
C	HOH318

---

site_id	AD2
Number of Residues	14
Details	binding site for Di-peptide ASP C 290 and PF5 C 291

Chain	Residue
B	HOH641
C	PF5288
C	GLU289
C	ALA293
C	HOH302
C	HOH309
A	TYR395
B	LEU337
B	TRP375
B	MET384
B	LYS388
B	ARG391
B	GLY392
B	TYR395

---

Functional Information from PROSITE/UniProt

site_id	PS00345
Number of Residues	9
Details	ETS_DOMAIN_1 Ets-domain signature 1. LWQFLLELL

Chain	Residue	Details
A	LEU337-LEU345

---

site_id	PS00346
Number of Residues	16
Details	ETS_DOMAIN_2 Ets-domain signature 2. KpkMnYEkLSRGLRyY

Chain	Residue	Details
A	LYS381-TYR396

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	DNA_BIND: ETS => ECO:0000255|PROSITE-ProRule:PRU00237

Chain	Residue	Details
A	ILE335-VAL415
B	ILE335-VAL415

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P14921

Chain	Residue	Details
A	LYS305
B	LYS305

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