Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | ARG311 |
| A | LYS316 |
| A | ARG374 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 501 |
| Chain | Residue |
| A | ILE335 |
| A | LYS379 |
| B | ILE335 |
| B | ARG378 |
| B | LYS379 |
| B | HOH603 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | ARG311 |
| B | LYS316 |
| B | ARG373 |
| B | ARG374 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residues SEP C 282 and PF5 C 283 |
| Chain | Residue |
| B | GLN336 |
| B | TRP338 |
| B | LYS399 |
| B | ILE401 |
| B | LEU421 |
| C | ASP284 |
| C | SEP285 |
| C | PF5286 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide PF5 C 283 and ASP C 284 |
| Chain | Residue |
| B | GLN336 |
| B | TRP338 |
| B | ILE401 |
| B | LEU421 |
| C | SEP282 |
| C | SEP285 |
| C | PF5286 |
| C | HOH304 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide ASP C 284 and SEP C 285 |
| Chain | Residue |
| A | LYS381 |
| A | LYS388 |
| C | SEP282 |
| C | PF5283 |
| C | PF5286 |
| C | HOH304 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residues SEP C 285 and PF5 C 286 |
| Chain | Residue |
| A | LYS381 |
| A | LYS388 |
| B | GLN336 |
| B | TYR395 |
| B | TYR396 |
| C | PF5283 |
| C | ASP284 |
| C | ASP287 |
| C | PF5288 |
| C | ALA293 |
| C | HOH302 |
| C | HOH304 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide PF5 C 286 and ASP C 287 |
| Chain | Residue |
| A | LYS381 |
| B | GLN336 |
| B | TYR395 |
| B | TYR396 |
| C | PF5283 |
| C | ASP284 |
| C | SEP285 |
| C | PF5288 |
| C | ALA293 |
| C | LEU295 |
| C | TRP296 |
| C | HOH302 |
| C | HOH308 |
| C | HOH312 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide ASP C 287 and PF5 C 288 |
| Chain | Residue |
| A | LYS381 |
| A | LYS388 |
| A | ARG391 |
| B | TYR395 |
| C | PF5286 |
| C | GLU289 |
| C | ASP290 |
| C | PF5291 |
| C | ALA293 |
| C | LEU295 |
| C | TRP296 |
| C | HOH308 |
| C | HOH312 |
| C | HOH318 |
| site_id | AD1 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide PF5 C 288 and GLU C 289 |
| Chain | Residue |
| A | GLN336 |
| A | LEU337 |
| A | LYS388 |
| A | ARG391 |
| A | TYR396 |
| A | HOH617 |
| B | TYR395 |
| C | PF5286 |
| C | ASP287 |
| C | ASP290 |
| C | PF5291 |
| C | TRP296 |
| C | HOH308 |
| C | HOH310 |
| C | HOH313 |
| C | HOH318 |
| site_id | AD2 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide ASP C 290 and PF5 C 291 |
| Chain | Residue |
| B | HOH641 |
| C | PF5288 |
| C | GLU289 |
| C | ALA293 |
| C | HOH302 |
| C | HOH309 |
| A | TYR395 |
| B | LEU337 |
| B | TRP375 |
| B | MET384 |
| B | LYS388 |
| B | ARG391 |
| B | GLY392 |
| B | TYR395 |
Functional Information from PROSITE/UniProt
| site_id | PS00345 |
| Number of Residues | 9 |
| Details | ETS_DOMAIN_1 Ets-domain signature 1. LWQFLLELL |
| Chain | Residue | Details |
| A | LEU337-LEU345 | |
| site_id | PS00346 |
| Number of Residues | 16 |
| Details | ETS_DOMAIN_2 Ets-domain signature 2. KpkMnYEkLSRGLRyY |
| Chain | Residue | Details |
| A | LYS381-TYR396 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | DNA binding: {"description":"ETS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00237","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Region: {"description":"Helix HI-1","evidences":[{"source":"PubMed","id":"15591056","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Region: {"description":"Helix HI-2","evidences":[{"source":"PubMed","id":"15591056","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Region: {"description":"Helix H4","evidences":[{"source":"PubMed","id":"15591056","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Region: {"description":"Helix H5","evidences":[{"source":"PubMed","id":"15591056","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P14921","evidenceCode":"ECO:0000250"}]} |
