6D9S
The (p)ppGpp-bound crystal structure of HPRT (hypoxanthine phosphoribosyltransferase)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006178 | biological_process | guanine salvage |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006178 | biological_process | guanine salvage |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue G4P A 201 |
| Chain | Residue |
| A | LEU42 |
| A | GLU151 |
| A | PHE152 |
| A | VAL153 |
| A | LEU158 |
| A | ASP159 |
| A | ARG165 |
| A | MG202 |
| A | HOH301 |
| A | HOH304 |
| A | HOH323 |
| A | LYS43 |
| A | HOH325 |
| A | HOH338 |
| A | HOH343 |
| A | HOH346 |
| A | HOH351 |
| A | GLY44 |
| A | ILE101 |
| A | ASP103 |
| A | SER104 |
| A | GLY105 |
| A | LEU106 |
| A | LYS131 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | ASP159 |
| A | G4P201 |
| A | HOH325 |
| A | HOH336 |
| A | HOH343 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 203 |
| Chain | Residue |
| A | ASN3 |
| A | ILE6 |
| A | GLU7 |
| A | VAL9 |
| A | TYR169 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 205 |
| Chain | Residue |
| A | GLN163 |
| A | TYR164 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 206 |
| Chain | Residue |
| A | GLU61 |
| B | GLN163 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | binding site for residue G4P B 201 |
| Chain | Residue |
| B | LEU42 |
| B | LYS43 |
| B | GLY44 |
| B | ILE101 |
| B | ILE102 |
| B | ASP103 |
| B | SER104 |
| B | GLY105 |
| B | LYS131 |
| B | PHE152 |
| B | VAL153 |
| B | LEU158 |
| B | ASP159 |
| B | ARG165 |
| B | MG202 |
| B | HOH301 |
| B | HOH302 |
| B | HOH305 |
| B | HOH306 |
| B | HOH333 |
| B | HOH338 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | ASP159 |
| B | ARG165 |
| B | G4P201 |
| B | HOH301 |
| B | HOH306 |
| B | HOH333 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue PEG B 203 |
| Chain | Residue |
| B | ILE6 |
| B | VAL9 |
| B | TYR169 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue PEG B 204 |
| Chain | Residue |
| B | ASP94 |
| B | LYS121 |
| B | SER122 |
| B | LYS124 |
| B | TYR143 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. ILIVEDIIDSGlT |
| Chain | Residue | Details |
| A | ILE95-THR107 |
