6D8P

Ternary RsAgo Complex Containing Guide RNA Paired with Target DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0004520	molecular_function	DNA endonuclease activity
A	0044355	biological_process	clearance of foreign intracellular DNA
A	0046872	molecular_function	metal ion binding
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0004520	molecular_function	DNA endonuclease activity
B	0044355	biological_process	clearance of foreign intracellular DNA
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG A 801

Chain	Residue
A	LEU108
A	PRO109
A	LYS110

---

site_id	AC2
Number of Residues	3
Details	binding site for residue MG A 804

Chain	Residue
A	SER395
A	LYS396
A	HOH1040

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG A 805

Chain	Residue
A	GLU451
A	MET482
A	HOH1116

---

site_id	AC4
Number of Residues	3
Details	binding site for residue ACT A 807

Chain	Residue
A	THR173
A	HIS641
A	PRO642

---

site_id	AC5
Number of Residues	2
Details	binding site for residue ACT A 808

Chain	Residue
A	LYS396
A	HOH1005

---

site_id	AC6
Number of Residues	2
Details	binding site for residue ACT A 809

Chain	Residue
A	MET528
A	HOH1148

---

site_id	AC7
Number of Residues	5
Details	binding site for residue ACT A 810

Chain	Residue
A	HIS516
A	TYR557
A	TYR717
A	GLN721
A	LYS724

---

site_id	AC8
Number of Residues	2
Details	binding site for residue ACT A 811

Chain	Residue
A	TRP761
A	HOH908

---

site_id	AC9
Number of Residues	2
Details	binding site for residue ACT A 812

Chain	Residue
A	ALA113
A	VAL114

---

site_id	AD1
Number of Residues	1
Details	binding site for residue ACT A 813

Chain	Residue
A	SER578

---

site_id	AD2
Number of Residues	8
Details	binding site for residue ACT A 814

Chain	Residue
A	TYR494
A	GLN497
A	ASN498
A	THR733
A	HOH901
E	HOH225
J	DA3
J	DA4

---

site_id	AD3
Number of Residues	2
Details	binding site for residue ACT A 815

Chain	Residue
A	ARG455
A	HOH1117

---

site_id	AD4
Number of Residues	3
Details	binding site for residue ACT A 816

Chain	Residue
A	ARG319
A	ARG322
A	ASP716

---

site_id	AD5
Number of Residues	2
Details	binding site for residue CAC A 818

Chain	Residue
A	GLN21
A	LEU22

---

site_id	AD6
Number of Residues	2
Details	binding site for residue CAC A 819

Chain	Residue
A	TYR111
A	PHE290

---

site_id	AD7
Number of Residues	2
Details	binding site for residue CAC A 820

Chain	Residue
A	ARG384
A	PHE409

---

site_id	AD8
Number of Residues	5
Details	binding site for residue MG E 101

Chain	Residue
A	LEU777
A	HOH973
E	U1
E	A3
E	HOH208

---

site_id	AD9
Number of Residues	3
Details	binding site for residue ACT E 102

Chain	Residue
E	U5
E	G6
E	HOH213

---

site_id	AE1
Number of Residues	2
Details	binding site for residue ACT E 103

Chain	Residue
E	C7
E	HOH227

---

site_id	AE2
Number of Residues	3
Details	binding site for residue ACT J 101

Chain	Residue
J	DC-12
J	DG-11
J	DT-10

---

site_id	AE3
Number of Residues	2
Details	binding site for residue ACT B 801

Chain	Residue
B	ARG20
B	HOH999

---

site_id	AE4
Number of Residues	2
Details	binding site for residue ACT B 802

Chain	Residue
B	ARG384
B	VAL407

---

site_id	AE5
Number of Residues	2
Details	binding site for residue ACT B 803

Chain	Residue
B	TYR571
B	ARG606

---

site_id	AE6
Number of Residues	7
Details	binding site for residue ACT B 804

Chain	Residue
B	HIS639
B	VAL685
B	THR700
B	LEU702
B	ALA737
B	HOH966
C	HOH215

---

site_id	AE7
Number of Residues	3
Details	binding site for residue CAC B 805

Chain	Residue
B	GLU377
B	ARG384
B	PHE409

---

site_id	AE8
Number of Residues	5
Details	binding site for residue MG C 101

Chain	Residue
B	LEU777
B	HOH972
C	U1
C	A3
C	HOH203

---

site_id	AE9
Number of Residues	4
Details	binding site for residue MPD C 102

Chain	Residue
B	LYS115
C	G11
C	G12
G	DC-7

---

site_id	AF1
Number of Residues	3
Details	binding site for residue ACT G 101

Chain	Residue
B	GLU746
G	DT-5
G	DG-4

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	624
Details	Domain: {"description":"Piwi","evidences":[{"source":"PROSITE-ProRule","id":"PRU00150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	148
Details	Region: {"description":"Linker L1","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	60
Details	Region: {"description":"PAZ domain","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	194
Details	Region: {"description":"Linker L2","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	334
Details	Region: {"description":"Mid domain","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	534
Details	Region: {"description":"PIWI domain","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29996105","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5AWH","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6D8P","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---