6D3G
PER-2 class A extended-spectrum beta-lactamase crystal structure in complex with avibactam at 2.4 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0017001 | biological_process | antibiotic catabolic process |
| A | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| A | 0046677 | biological_process | response to antibiotic |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0017001 | biological_process | antibiotic catabolic process |
| B | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| B | 0046677 | biological_process | response to antibiotic |
| C | 0008800 | molecular_function | beta-lactamase activity |
| C | 0017001 | biological_process | antibiotic catabolic process |
| C | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| C | 0046677 | biological_process | response to antibiotic |
| D | 0008800 | molecular_function | beta-lactamase activity |
| D | 0017001 | biological_process | antibiotic catabolic process |
| D | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| D | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue NXL A 401 |
| Chain | Residue |
| A | GLN69 |
| A | THR235 |
| A | GLY236 |
| A | THR237 |
| A | SER70 |
| A | LYS73 |
| A | TRP105 |
| A | SER130 |
| A | ASN132 |
| A | GLU166 |
| A | HIS170 |
| A | LYS234 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue PG4 B 402 |
| Chain | Residue |
| A | PRO62 |
| A | PHE63 |
| A | LYS65 |
| A | GLU159 |
| B | LYS65 |
| B | TYR177 |
| B | TRP180 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide NXL B 401 and SER B 70 |
| Chain | Residue |
| B | MET68 |
| B | GLN69 |
| B | VAL71 |
| B | PHE72 |
| B | LYS73 |
| B | TRP105 |
| B | SER130 |
| B | ASN132 |
| B | HIS170 |
| B | THR216 |
| B | LYS234 |
| B | THR235 |
| B | GLY236 |
| B | THR237 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide NXL C 401 and SER C 70 |
| Chain | Residue |
| C | MET68 |
| C | GLN69 |
| C | VAL71 |
| C | PHE72 |
| C | LYS73 |
| C | TRP105 |
| C | SER130 |
| C | ASN132 |
| C | GLU166 |
| C | HIS170 |
| C | THR216 |
| C | LYS234 |
| C | THR235 |
| C | GLY236 |
| C | THR237 |
| C | HOH510 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide NXL D 401 and SER D 70 |
| Chain | Residue |
| D | MET68 |
| D | GLN69 |
| D | VAL71 |
| D | PHE72 |
| D | LYS73 |
| D | TRP105 |
| D | SER130 |
| D | ASN132 |
| D | GLU166 |
| D | THR216 |
| D | LYS234 |
| D | THR235 |
| D | GLY236 |
| D | THR237 |
Functional Information from PROSITE/UniProt
| site_id | PS00146 |
| Number of Residues | 16 |
| Details | BETA_LACTAMASE_A Beta-lactamase class-A active site. FpMQSVfKlhlAMLVL |
| Chain | Residue | Details |
| A | PHE66-LEU81 |
