Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6D36

Structure of human ARH3 bound to ADP-ribose and magnesium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006281	biological_process	DNA repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0006974	biological_process	DNA damage response
A	0016604	cellular_component	nuclear body
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0060546	biological_process	negative regulation of necroptotic process
A	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
A	0071451	biological_process	cellular response to superoxide
A	0090734	cellular_component	site of DNA damage
A	0140290	biological_process	peptidyl-serine ADP-deribosylation
A	0140292	molecular_function	ADP-ribosylserine hydrolase activity
B	0000287	molecular_function	magnesium ion binding
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006281	biological_process	DNA repair
B	0006287	biological_process	base-excision repair, gap-filling
B	0006974	biological_process	DNA damage response
B	0016604	cellular_component	nuclear body
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0060546	biological_process	negative regulation of necroptotic process
B	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
B	0071451	biological_process	cellular response to superoxide
B	0090734	cellular_component	site of DNA damage
B	0140290	biological_process	peptidyl-serine ADP-deribosylation
B	0140292	molecular_function	ADP-ribosylserine hydrolase activity
C	0000287	molecular_function	magnesium ion binding
C	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
C	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006281	biological_process	DNA repair
C	0006287	biological_process	base-excision repair, gap-filling
C	0006974	biological_process	DNA damage response
C	0016604	cellular_component	nuclear body
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
C	0060546	biological_process	negative regulation of necroptotic process
C	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
C	0071451	biological_process	cellular response to superoxide
C	0090734	cellular_component	site of DNA damage
C	0140290	biological_process	peptidyl-serine ADP-deribosylation
C	0140292	molecular_function	ADP-ribosylserine hydrolase activity
D	0000287	molecular_function	magnesium ion binding
D	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
D	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006281	biological_process	DNA repair
D	0006287	biological_process	base-excision repair, gap-filling
D	0006974	biological_process	DNA damage response
D	0016604	cellular_component	nuclear body
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	0060546	biological_process	negative regulation of necroptotic process
D	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
D	0071451	biological_process	cellular response to superoxide
D	0090734	cellular_component	site of DNA damage
D	0140290	biological_process	peptidyl-serine ADP-deribosylation
D	0140292	molecular_function	ADP-ribosylserine hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	binding site for residue AR6 C 401

Chain	Residue
C	ASP77
C	TYR149
C	GLY150
C	ASN151
C	GLY152
C	HIS182
C	ILE271
C	ASP314
C	THR317
C	MG402
C	MG403
C	GLY115
C	HOH502
C	HOH519
C	HOH554
C	HOH570
C	HOH595
C	HOH745
C	GLY117
C	ALA118
C	GLY119
C	VAL120
C	PHE143
C	GLY147
C	SER148

site_id	AC2
Number of Residues	7
Details	binding site for residue MG C 402

Chain	Residue
C	ASP314
C	ASP316
C	THR317
C	AR6401
C	MG403
C	HOH502
C	HOH519

site_id	AC3
Number of Residues	8
Details	binding site for residue MG C 403

Chain	Residue
C	THR76
C	ASP77
C	ASP78
C	ASP316
C	AR6401
C	MG402
C	HOH502
C	HOH583

site_id	AC4
Number of Residues	28
Details	binding site for residue AR6 D 401

Chain	Residue
D	ASP77
D	GLY115
D	GLY117
D	ALA118
D	GLY119
D	VAL120
D	PHE143
D	GLY147
D	SER148
D	TYR149
D	GLY150
D	ASN151
D	GLY152
D	MET155
D	HIS182
D	LEU235
D	ILE271
D	ASP314
D	THR317
D	MG402
D	MG403
D	HOH501
D	HOH505
D	HOH513
D	HOH540
D	HOH545
D	HOH567
D	HOH637

site_id	AC5
Number of Residues	7
Details	binding site for residue MG D 402

Chain	Residue
D	ASP314
D	ASP316
D	THR317
D	AR6401
D	MG403
D	HOH501
D	HOH513

site_id	AC6
Number of Residues	8
Details	binding site for residue MG D 403

Chain	Residue
D	THR76
D	ASP77
D	ASP78
D	ASP316
D	AR6401
D	MG402
D	HOH501
D	HOH534

site_id	AC7
Number of Residues	25
Details	binding site for residue AR6 A 401

Chain	Residue
A	THR317
A	MG402
A	MG403
A	HOH501
A	HOH532
A	HOH549
A	HOH579
A	HOH582
A	HOH703
A	ASP77
A	GLY115
A	GLY117
A	ALA118
A	GLY119
A	VAL120
A	PHE143
A	GLY147
A	SER148
A	TYR149
A	GLY150
A	ASN151
A	GLY152
A	HIS182
A	ILE271
A	ASP314

site_id	AC8
Number of Residues	8
Details	binding site for residue MG A 402

Chain	Residue
A	THR76
A	ASP77
A	ASP78
A	ASP316
A	AR6401
A	MG403
A	HOH501
A	HOH595

site_id	AC9
Number of Residues	7
Details	binding site for residue MG A 403

Chain	Residue
A	ASP314
A	ASP316
A	THR317
A	AR6401
A	MG402
A	HOH501
A	HOH532

site_id	AD1
Number of Residues	24
Details	binding site for residue AR6 B 401

Chain	Residue
B	ASP77
B	GLY115
B	GLY117
B	ALA118
B	GLY119
B	VAL120
B	PHE143
B	LYS146
B	GLY147
B	SER148
B	TYR149
B	GLY150
B	ASN151
B	GLY152
B	HIS182
B	ASP314
B	THR317
B	MG402
B	MG403
B	HOH501
B	HOH528
B	HOH554
B	HOH567
B	HOH574

site_id	AD2
Number of Residues	7
Details	binding site for residue MG B 402

Chain	Residue
B	ASP314
B	ASP316
B	THR317
B	AR6401
B	MG403
B	HOH501
B	HOH554

site_id	AD3
Number of Residues	8
Details	binding site for residue MG B 403

Chain	Residue
B	THR76
B	ASP77
B	ASP78
B	ASP316
B	AR6401
B	MG402
B	HOH501
B	HOH523

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7ARW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ARW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Glutamate flap","evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)