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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6CPL

Crystal structure of DR11 presenting the gag293 epitope

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001772cellular_componentimmunological synapse
A0001916biological_processpositive regulation of T cell mediated cytotoxicity
A0002250biological_processadaptive immune response
A0002376biological_processimmune system process
A0002469biological_processmyeloid dendritic cell antigen processing and presentation
A0002491biological_processantigen processing and presentation of endogenous peptide antigen via MHC class II
A0002503biological_processpeptide antigen assembly with MHC class II protein complex
A0002504biological_processantigen processing and presentation of peptide or polysaccharide antigen via MHC class II
A0005515molecular_functionprotein binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006955biological_processimmune response
A0009986cellular_componentcell surface
A0012507cellular_componentER to Golgi transport vesicle membrane
A0016020cellular_componentmembrane
A0019882biological_processantigen processing and presentation
A0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
A0023026molecular_functionMHC class II protein complex binding
A0030247molecular_functionpolysaccharide binding
A0030658cellular_componenttransport vesicle membrane
A0030666cellular_componentendocytic vesicle membrane
A0030669cellular_componentclathrin-coated endocytic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031901cellular_componentearly endosome membrane
A0031902cellular_componentlate endosome membrane
A0032588cellular_componenttrans-Golgi network membrane
A0032831biological_processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
A0042605molecular_functionpeptide antigen binding
A0042608molecular_functionT cell receptor binding
A0042613cellular_componentMHC class II protein complex
A0043382biological_processpositive regulation of memory T cell differentiation
A0045622biological_processregulation of T-helper cell differentiation
A0050778biological_processpositive regulation of immune response
A0050870biological_processpositive regulation of T cell activation
A0050890biological_processcognition
A0070062cellular_componentextracellular exosome
A0098553cellular_componentlumenal side of endoplasmic reticulum membrane
A0120281cellular_componentautolysosome membrane
A2000516biological_processpositive regulation of CD4-positive, alpha-beta T cell activation
B0006955biological_processimmune response
B0016020cellular_componentmembrane
B0019882biological_processantigen processing and presentation
B0042613cellular_componentMHC class II protein complex
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH
ChainResidueDetails
ATYR161-HIS167
BTYR171-HIS177
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues180
DetailsDomain: {"description":"Ig-like C1-type"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues93
DetailsRegion: {"description":"Alpha-2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsSite: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsSite: {"description":"Self-peptide antigen","evidences":[{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsSite: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsSite: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsSite: {"description":"Pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsSite: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsSite: {"description":"Pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsSite: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7477400","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19303388","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24190431","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues
DetailsM-CSA 175
ChainResidueDetails

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PDB entries from 2025-12-17

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