6CLU

Staphylococcus aureus Dihydropteroate Synthase (saDHPS) F17L E208K double mutant structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004156	molecular_function	dihydropteroate synthase activity
A	0009396	biological_process	folic acid-containing compound biosynthetic process
A	0016740	molecular_function	transferase activity
A	0042558	biological_process	pteridine-containing compound metabolic process
A	0044237	biological_process	cellular metabolic process
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046656	biological_process	folic acid biosynthetic process
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
B	0004156	molecular_function	dihydropteroate synthase activity
B	0009396	biological_process	folic acid-containing compound biosynthetic process
B	0016740	molecular_function	transferase activity
B	0042558	biological_process	pteridine-containing compound metabolic process
B	0044237	biological_process	cellular metabolic process
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046656	biological_process	folic acid biosynthetic process
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
C	0004156	molecular_function	dihydropteroate synthase activity
C	0009396	biological_process	folic acid-containing compound biosynthetic process
C	0016740	molecular_function	transferase activity
C	0042558	biological_process	pteridine-containing compound metabolic process
C	0044237	biological_process	cellular metabolic process
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0046656	biological_process	folic acid biosynthetic process
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
D	0004156	molecular_function	dihydropteroate synthase activity
D	0009396	biological_process	folic acid-containing compound biosynthetic process
D	0016740	molecular_function	transferase activity
D	0042558	biological_process	pteridine-containing compound metabolic process
D	0044237	biological_process	cellular metabolic process
D	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0046656	biological_process	folic acid biosynthetic process
D	0046677	biological_process	response to antibiotic
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00792
Number of Residues	16
Details	DHPS_1 Dihydropteroate synthase signature 1. ImGILNvTpDSLsDgG

Chain	Residue	Details
A	ILE6-GLY21

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site_id	PS00793
Number of Residues	14
Details	DHPS_2 Dihydropteroate synthase signature 2. GAdIIDVGGvsTrP

Chain	Residue	Details
A	GLY40-PRO53

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:9149138

Chain	Residue	Details
A	ASN11
B	ASN11
C	ASN11
D	ASN11

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site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000305|PubMed:9149138, ECO:0007744|PDB:1AD4

Chain	Residue	Details
A	ARG52
B	ASP167
B	LYS203
B	ARG239
C	ARG52
C	ASP84
C	ASN103
C	ASP167
C	LYS203
C	ARG239
D	ARG52
A	ASP84
D	ASP84
D	ASN103
D	ASP167
D	LYS203
D	ARG239
A	ASN103
A	ASP167
A	LYS203
A	ARG239
B	ARG52
B	ASP84
B	ASN103

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