Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6CJU

Structure of the SthK cyclic nucleotide-gated potassium channel in complex with cAMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005222	molecular_function	intracellularly cAMP-activated cation channel activity
A	0005223	molecular_function	intracellularly cGMP-activated cation channel activity
A	0005886	cellular_component	plasma membrane
A	0016020	cellular_component	membrane
A	0017071	cellular_component	intracellular cyclic nucleotide activated cation channel complex
A	0030553	molecular_function	cGMP binding
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0044877	molecular_function	protein-containing complex binding
A	0098655	biological_process	monoatomic cation transmembrane transport
B	0005222	molecular_function	intracellularly cAMP-activated cation channel activity
B	0005223	molecular_function	intracellularly cGMP-activated cation channel activity
B	0005886	cellular_component	plasma membrane
B	0016020	cellular_component	membrane
B	0017071	cellular_component	intracellular cyclic nucleotide activated cation channel complex
B	0030553	molecular_function	cGMP binding
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0044877	molecular_function	protein-containing complex binding
B	0098655	biological_process	monoatomic cation transmembrane transport
C	0005222	molecular_function	intracellularly cAMP-activated cation channel activity
C	0005223	molecular_function	intracellularly cGMP-activated cation channel activity
C	0005886	cellular_component	plasma membrane
C	0016020	cellular_component	membrane
C	0017071	cellular_component	intracellular cyclic nucleotide activated cation channel complex
C	0030553	molecular_function	cGMP binding
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0044877	molecular_function	protein-containing complex binding
C	0098655	biological_process	monoatomic cation transmembrane transport
D	0005222	molecular_function	intracellularly cAMP-activated cation channel activity
D	0005223	molecular_function	intracellularly cGMP-activated cation channel activity
D	0005886	cellular_component	plasma membrane
D	0016020	cellular_component	membrane
D	0017071	cellular_component	intracellular cyclic nucleotide activated cation channel complex
D	0030553	molecular_function	cGMP binding
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0044877	molecular_function	protein-containing complex binding
D	0098655	biological_process	monoatomic cation transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CMP A 500

Chain	Residue
A	GLY367
A	GLU368
A	MET369
A	ARG377
A	THR378
A	ALA379

site_id	AC2
Number of Residues	2
Details	binding site for residue PGW A 501

Chain	Residue
A	GLY167
B	VAL198

site_id	AC3
Number of Residues	2
Details	binding site for residue PGW A 503

Chain	Residue
A	TYR170
A	LEU32

site_id	AC4
Number of Residues	5
Details	binding site for residue PGW A 506

Chain	Residue
A	SER102
A	LEU109
A	PHE143
A	GLY150
A	SER157

site_id	AC5
Number of Residues	2
Details	binding site for residue PGW A 507

Chain	Residue
A	THR195
A	VAL202

site_id	AC6
Number of Residues	6
Details	binding site for residue CMP B 500

Chain	Residue
B	GLY367
B	GLU368
B	MET369
B	ARG377
B	THR378
B	ALA379

site_id	AC7
Number of Residues	2
Details	binding site for residue PGW B 501

Chain	Residue
B	GLY167
C	VAL198

site_id	AC8
Number of Residues	2
Details	binding site for residue PGW B 503

Chain	Residue
B	LEU32
B	TYR170

site_id	AC9
Number of Residues	5
Details	binding site for residue PGW B 506

Chain	Residue
B	SER102
B	LEU109
B	PHE143
B	GLY150
B	SER157

site_id	AD1
Number of Residues	2
Details	binding site for residue PGW B 507

Chain	Residue
B	THR195
B	VAL202

site_id	AD2
Number of Residues	6
Details	binding site for residue CMP C 500

Chain	Residue
C	GLY367
C	GLU368
C	MET369
C	ARG377
C	THR378
C	ALA379

site_id	AD3
Number of Residues	2
Details	binding site for residue PGW C 501

Chain	Residue
C	GLY167
D	VAL198

site_id	AD4
Number of Residues	2
Details	binding site for residue PGW C 503

Chain	Residue
C	LEU32
C	TYR170

site_id	AD5
Number of Residues	5
Details	binding site for residue PGW C 506

Chain	Residue
C	SER102
C	LEU109
C	PHE143
C	GLY150
C	SER157

site_id	AD6
Number of Residues	2
Details	binding site for residue PGW C 507

Chain	Residue
C	THR195
C	VAL202

site_id	AD7
Number of Residues	6
Details	binding site for residue CMP D 500

Chain	Residue
D	GLY367
D	GLU368
D	MET369
D	ARG377
D	THR378
D	ALA379

site_id	AD8
Number of Residues	2
Details	binding site for residue PGW D 501

Chain	Residue
A	VAL198
D	GLY167

site_id	AD9
Number of Residues	2
Details	binding site for residue PGW D 503

Chain	Residue
D	LEU32
D	TYR170

site_id	AE1
Number of Residues	5
Details	binding site for residue PGW D 506

Chain	Residue
D	SER102
D	LEU109
D	PHE143
D	GLY150
D	SER157

site_id	AE2
Number of Residues	2
Details	binding site for residue PGW D 507

Chain	Residue
D	THR195
D	VAL202

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrAGEmGSdVYFInrG

Chain	Residue	Details
A	ILE328-GLY344

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEmALilrap......RTAtVrA

Chain	Residue	Details
A	PHE366-ALA383

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)