6CJA

Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 in complex with Alanyl-PLP and Serine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003962	molecular_function	cystathionine gamma-synthase activity
A	0005737	cellular_component	cytoplasm
A	0016829	molecular_function	lyase activity
A	0016846	molecular_function	carbon-sulfur lyase activity
A	0019346	biological_process	transsulfuration
A	0030170	molecular_function	pyridoxal phosphate binding
B	0003962	molecular_function	cystathionine gamma-synthase activity
B	0005737	cellular_component	cytoplasm
B	0016829	molecular_function	lyase activity
B	0016846	molecular_function	carbon-sulfur lyase activity
B	0019346	biological_process	transsulfuration
B	0030170	molecular_function	pyridoxal phosphate binding
C	0003962	molecular_function	cystathionine gamma-synthase activity
C	0005737	cellular_component	cytoplasm
C	0016829	molecular_function	lyase activity
C	0016846	molecular_function	carbon-sulfur lyase activity
C	0019346	biological_process	transsulfuration
C	0030170	molecular_function	pyridoxal phosphate binding
D	0003962	molecular_function	cystathionine gamma-synthase activity
D	0005737	cellular_component	cytoplasm
D	0016829	molecular_function	lyase activity
D	0016846	molecular_function	carbon-sulfur lyase activity
D	0019346	biological_process	transsulfuration
D	0030170	molecular_function	pyridoxal phosphate binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue F0G A 401

Chain	Residue
A	SER76
A	SER328
A	THR343
A	ARG363
B	TYR47
B	ARG49
A	GLY77
A	MET78
A	TYR101
A	ASN149
A	ASP174
A	SER196
A	THR198
A	LYS199

---

site_id	AC2
Number of Residues	12
Details	binding site for residue SER A 402

Chain	Residue
A	TYR101
A	ARG106
A	GLU327
A	MET342
A	THR343
A	HOH520
A	HOH729
A	HOH750
B	GLU46
B	ARG49
B	THR50
B	ASN229

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 403

Chain	Residue
A	LYS35
A	HIS42
A	LEU43
A	HOH526
A	HOH793
D	GLY22
D	HOH570

---

site_id	AC4
Number of Residues	11
Details	binding site for residue SER A 404

Chain	Residue
A	GLU46
A	ARG49
A	THR50
A	ASN229
B	TYR101
B	ARG106
B	GLU327
B	MET342
B	THR343
B	HOH520
B	HOH772

---

site_id	AC5
Number of Residues	14
Details	binding site for residue F0G B 401

Chain	Residue
A	TYR47
A	ARG49
B	SER76
B	GLY77
B	MET78
B	TYR101
B	ASN149
B	ASP174
B	SER196
B	THR198
B	LYS199
B	SER328
B	THR343
B	ARG363

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL B 402

Chain	Residue
B	LYS35
B	HIS42
B	LEU43
B	HOH569
B	HOH596
C	GLY22
C	HOH562

---

site_id	AC7
Number of Residues	14
Details	binding site for residue F0G C 400

Chain	Residue
C	SER76
C	GLY77
C	MET78
C	TYR101
C	ASN149
C	ASP174
C	SER196
C	THR198
C	LYS199
C	SER328
C	THR343
C	ARG363
D	TYR47
D	ARG49

---

site_id	AC8
Number of Residues	11
Details	binding site for residue SER C 401

Chain	Residue
C	TYR101
C	ARG106
C	GLU327
C	MET342
C	HOH516
C	HOH565
C	HOH665
D	GLU46
D	ARG49
D	THR50
D	ASN229

---

site_id	AC9
Number of Residues	9
Details	binding site for residue GOL C 402

Chain	Residue
C	GLU311
C	ASP312
C	ARG315
C	HOH563
C	HOH585
C	HOH601
D	LYS273
D	ASP312
D	HOH584

---

site_id	AD1
Number of Residues	15
Details	binding site for residue F0G D 400

Chain	Residue
C	TYR47
C	ARG49
D	SER76
D	GLY77
D	MET78
D	TYR101
D	ASN149
D	ASP174
D	SER196
D	THR198
D	LYS199
D	SER328
D	LEU329
D	THR343
D	ARG363

---

site_id	AD2
Number of Residues	11
Details	binding site for residue SER D 401

Chain	Residue
C	GLU46
C	ARG49
C	THR50
C	ASN229
D	TYR101
D	ARG106
D	GLU327
D	MET342
D	HOH524
D	HOH642
D	HOH701

---

Functional Information from PROSITE/UniProt

site_id	PS00868
Number of Residues	15
Details	CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DIvlhSATKYLnGHS

Chain	Residue	Details
A	ASP191-SER205

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