6CJA
Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 in complex with Alanyl-PLP and Serine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000096 | biological_process | sulfur amino acid metabolic process |
| A | 0003962 | molecular_function | cystathionine gamma-synthase activity |
| A | 0004123 | molecular_function | cystathionine gamma-lyase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016846 | molecular_function | carbon-sulfur lyase activity |
| A | 0019343 | biological_process | L-cysteine biosynthetic process via L-cystathionine |
| A | 0019346 | biological_process | transsulfuration |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0000096 | biological_process | sulfur amino acid metabolic process |
| B | 0003962 | molecular_function | cystathionine gamma-synthase activity |
| B | 0004123 | molecular_function | cystathionine gamma-lyase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016846 | molecular_function | carbon-sulfur lyase activity |
| B | 0019343 | biological_process | L-cysteine biosynthetic process via L-cystathionine |
| B | 0019346 | biological_process | transsulfuration |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0000096 | biological_process | sulfur amino acid metabolic process |
| C | 0003962 | molecular_function | cystathionine gamma-synthase activity |
| C | 0004123 | molecular_function | cystathionine gamma-lyase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016846 | molecular_function | carbon-sulfur lyase activity |
| C | 0019343 | biological_process | L-cysteine biosynthetic process via L-cystathionine |
| C | 0019346 | biological_process | transsulfuration |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0000096 | biological_process | sulfur amino acid metabolic process |
| D | 0003962 | molecular_function | cystathionine gamma-synthase activity |
| D | 0004123 | molecular_function | cystathionine gamma-lyase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016846 | molecular_function | carbon-sulfur lyase activity |
| D | 0019343 | biological_process | L-cysteine biosynthetic process via L-cystathionine |
| D | 0019346 | biological_process | transsulfuration |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue F0G A 401 |
| Chain | Residue |
| A | SER76 |
| A | SER328 |
| A | THR343 |
| A | ARG363 |
| B | TYR47 |
| B | ARG49 |
| A | GLY77 |
| A | MET78 |
| A | TYR101 |
| A | ASN149 |
| A | ASP174 |
| A | SER196 |
| A | THR198 |
| A | LYS199 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue SER A 402 |
| Chain | Residue |
| A | TYR101 |
| A | ARG106 |
| A | GLU327 |
| A | MET342 |
| A | THR343 |
| A | HOH520 |
| A | HOH729 |
| A | HOH750 |
| B | GLU46 |
| B | ARG49 |
| B | THR50 |
| B | ASN229 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | LYS35 |
| A | HIS42 |
| A | LEU43 |
| A | HOH526 |
| A | HOH793 |
| D | GLY22 |
| D | HOH570 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue SER A 404 |
| Chain | Residue |
| A | GLU46 |
| A | ARG49 |
| A | THR50 |
| A | ASN229 |
| B | TYR101 |
| B | ARG106 |
| B | GLU327 |
| B | MET342 |
| B | THR343 |
| B | HOH520 |
| B | HOH772 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue F0G B 401 |
| Chain | Residue |
| A | TYR47 |
| A | ARG49 |
| B | SER76 |
| B | GLY77 |
| B | MET78 |
| B | TYR101 |
| B | ASN149 |
| B | ASP174 |
| B | SER196 |
| B | THR198 |
| B | LYS199 |
| B | SER328 |
| B | THR343 |
| B | ARG363 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| B | LYS35 |
| B | HIS42 |
| B | LEU43 |
| B | HOH569 |
| B | HOH596 |
| C | GLY22 |
| C | HOH562 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue F0G C 400 |
| Chain | Residue |
| C | SER76 |
| C | GLY77 |
| C | MET78 |
| C | TYR101 |
| C | ASN149 |
| C | ASP174 |
| C | SER196 |
| C | THR198 |
| C | LYS199 |
| C | SER328 |
| C | THR343 |
| C | ARG363 |
| D | TYR47 |
| D | ARG49 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue SER C 401 |
| Chain | Residue |
| C | TYR101 |
| C | ARG106 |
| C | GLU327 |
| C | MET342 |
| C | HOH516 |
| C | HOH565 |
| C | HOH665 |
| D | GLU46 |
| D | ARG49 |
| D | THR50 |
| D | ASN229 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 402 |
| Chain | Residue |
| C | GLU311 |
| C | ASP312 |
| C | ARG315 |
| C | HOH563 |
| C | HOH585 |
| C | HOH601 |
| D | LYS273 |
| D | ASP312 |
| D | HOH584 |
| site_id | AD1 |
| Number of Residues | 15 |
| Details | binding site for residue F0G D 400 |
| Chain | Residue |
| C | TYR47 |
| C | ARG49 |
| D | SER76 |
| D | GLY77 |
| D | MET78 |
| D | TYR101 |
| D | ASN149 |
| D | ASP174 |
| D | SER196 |
| D | THR198 |
| D | LYS199 |
| D | SER328 |
| D | LEU329 |
| D | THR343 |
| D | ARG363 |
| site_id | AD2 |
| Number of Residues | 11 |
| Details | binding site for residue SER D 401 |
| Chain | Residue |
| C | GLU46 |
| C | ARG49 |
| C | THR50 |
| C | ASN229 |
| D | TYR101 |
| D | ARG106 |
| D | GLU327 |
| D | MET342 |
| D | HOH524 |
| D | HOH642 |
| D | HOH701 |
Functional Information from PROSITE/UniProt
| site_id | PS00868 |
| Number of Residues | 15 |
| Details | CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DIvlhSATKYLnGHS |
| Chain | Residue | Details |
| A | ASP191-SER205 |
