6CFV
Structure of Human alpha-Phosphomannomutase 1 in complex with Inosine Monophosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004615 | molecular_function | phosphomannomutase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006013 | biological_process | mannose metabolic process |
| A | 0006487 | biological_process | protein N-linked glycosylation |
| A | 0009298 | biological_process | GDP-mannose biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1901293 | biological_process | nucleoside phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 301 |
| Chain | Residue |
| A | ASP19 |
| A | ASP21 |
| A | ASN218 |
| A | HOH421 |
| A | HOH440 |
| A | HOH444 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 302 |
| Chain | Residue |
| A | ASP232 |
| A | THR235 |
| A | GLU168 |
| A | PHE230 |
| A | ALA231 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue IMP A 303 |
| Chain | Residue |
| A | ARG132 |
| A | MET135 |
| A | ASN137 |
| A | ARG143 |
| A | ARG150 |
| A | SER182 |
| A | GLY184 |
| A | GLY185 |
| A | MET186 |
| A | ILE187 |
| A | SER188 |
| A | ASP190 |
| A | ASN225 |
| A | HOH429 |
| A | HOH496 |
| A | HOH506 |
| A | HOH563 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"16540464","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"16540464","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16540464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FUC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FUE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16540464","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O35621","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
