6CFN

Crystal Structure of the DNA-free Glucocorticoid Receptor DNA Binding Domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0043565	molecular_function	sequence-specific DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0043565	molecular_function	sequence-specific DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008270	molecular_function	zinc ion binding
C	0043565	molecular_function	sequence-specific DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0043565	molecular_function	sequence-specific DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription
E	0008270	molecular_function	zinc ion binding
E	0043565	molecular_function	sequence-specific DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0006355	biological_process	regulation of DNA-templated transcription
F	0008270	molecular_function	zinc ion binding
F	0043565	molecular_function	sequence-specific DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0006355	biological_process	regulation of DNA-templated transcription
G	0008270	molecular_function	zinc ion binding
G	0043565	molecular_function	sequence-specific DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0006355	biological_process	regulation of DNA-templated transcription
H	0008270	molecular_function	zinc ion binding
H	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 601

Chain	Residue
A	CYS421
A	CYS424
A	CYS438
A	CYS441

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 602

Chain	Residue
A	CYS457
A	CYS463
A	CYS473
A	CYS476

---

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN B 601

Chain	Residue
B	VAL423
B	CYS424
B	CYS438
B	CYS441
B	CYS421

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 602

Chain	Residue
B	CYS457
B	CYS463
B	CYS473
B	CYS476

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN C 601

Chain	Residue
C	CYS421
C	CYS424
C	CYS438
C	CYS441

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN C 602

Chain	Residue
C	CYS457
C	CYS463
C	CYS473
C	CYS476

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN D 601

Chain	Residue
D	CYS421
D	CYS424
D	CYS438
D	CYS441

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN D 602

Chain	Residue
D	CYS457
D	CYS463
D	CYS473
D	CYS476

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN E 601

Chain	Residue
E	CYS421
E	CYS424
E	CYS438
E	CYS441

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN E 602

Chain	Residue
E	CYS457
E	CYS463
E	CYS473
E	CYS476

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN F 601

Chain	Residue
F	CYS421
F	CYS424
F	CYS438
F	CYS441

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN F 602

Chain	Residue
F	CYS457
F	CYS463
F	CYS473
F	CYS476

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN G 601

Chain	Residue
G	CYS421
G	CYS424
G	CYS438
G	CYS441

---

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN G 602

Chain	Residue
G	CYS457
G	CYS463
G	CYS473
G	CYS476

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN H 601

Chain	Residue
H	CYS421
H	CYS424
H	CYS438
H	CYS441

---

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN H 602

Chain	Residue
H	CYS457
H	CYS463
H	CYS473
H	CYS476

---

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. ClvCs.Deasgc.HYgvltCgsCkvFFkR

Chain	Residue	Details
A	CYS421-ARG447

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	312
Details	Zinc finger: {"description":"NR C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19141540","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P06537","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	75
Details	DNA binding: {"description":"Nuclear receptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---