6CFN
Crystal Structure of the DNA-free Glucocorticoid Receptor DNA Binding Domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0043565 | molecular_function | sequence-specific DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0043565 | molecular_function | sequence-specific DNA binding |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0043565 | molecular_function | sequence-specific DNA binding |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0008270 | molecular_function | zinc ion binding |
| F | 0043565 | molecular_function | sequence-specific DNA binding |
| G | 0003700 | molecular_function | DNA-binding transcription factor activity |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0008270 | molecular_function | zinc ion binding |
| G | 0043565 | molecular_function | sequence-specific DNA binding |
| H | 0003700 | molecular_function | DNA-binding transcription factor activity |
| H | 0006355 | biological_process | regulation of DNA-templated transcription |
| H | 0008270 | molecular_function | zinc ion binding |
| H | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 601 |
| Chain | Residue |
| A | CYS421 |
| A | CYS424 |
| A | CYS438 |
| A | CYS441 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 602 |
| Chain | Residue |
| A | CYS457 |
| A | CYS463 |
| A | CYS473 |
| A | CYS476 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 601 |
| Chain | Residue |
| B | VAL423 |
| B | CYS424 |
| B | CYS438 |
| B | CYS441 |
| B | CYS421 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 602 |
| Chain | Residue |
| B | CYS457 |
| B | CYS463 |
| B | CYS473 |
| B | CYS476 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 601 |
| Chain | Residue |
| C | CYS421 |
| C | CYS424 |
| C | CYS438 |
| C | CYS441 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 602 |
| Chain | Residue |
| C | CYS457 |
| C | CYS463 |
| C | CYS473 |
| C | CYS476 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 601 |
| Chain | Residue |
| D | CYS421 |
| D | CYS424 |
| D | CYS438 |
| D | CYS441 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 602 |
| Chain | Residue |
| D | CYS457 |
| D | CYS463 |
| D | CYS473 |
| D | CYS476 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 601 |
| Chain | Residue |
| E | CYS421 |
| E | CYS424 |
| E | CYS438 |
| E | CYS441 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 602 |
| Chain | Residue |
| E | CYS457 |
| E | CYS463 |
| E | CYS473 |
| E | CYS476 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 601 |
| Chain | Residue |
| F | CYS421 |
| F | CYS424 |
| F | CYS438 |
| F | CYS441 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 602 |
| Chain | Residue |
| F | CYS457 |
| F | CYS463 |
| F | CYS473 |
| F | CYS476 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN G 601 |
| Chain | Residue |
| G | CYS421 |
| G | CYS424 |
| G | CYS438 |
| G | CYS441 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN G 602 |
| Chain | Residue |
| G | CYS457 |
| G | CYS463 |
| G | CYS473 |
| G | CYS476 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN H 601 |
| Chain | Residue |
| H | CYS421 |
| H | CYS424 |
| H | CYS438 |
| H | CYS441 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN H 602 |
| Chain | Residue |
| H | CYS457 |
| H | CYS463 |
| H | CYS473 |
| H | CYS476 |
Functional Information from PROSITE/UniProt
| site_id | PS00031 |
| Number of Residues | 27 |
| Details | NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. ClvCs.Deasgc.HYgvltCgsCkvFFkR |
| Chain | Residue | Details |
| A | CYS421-ARG447 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 600 |
| Details | DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | PRO418-THR493 | |
| B | PRO418-THR493 | |
| C | PRO418-THR493 | |
| D | PRO418-THR493 | |
| E | PRO418-THR493 | |
| F | PRO418-THR493 | |
| G | PRO418-THR493 | |
| H | PRO418-THR493 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 312 |
| Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | CYS421-CYS441 | |
| E | CYS457-CYS476 | |
| F | CYS421-CYS441 | |
| F | CYS457-CYS476 | |
| G | CYS421-CYS441 | |
| G | CYS457-CYS476 | |
| H | CYS421-CYS441 | |
| H | CYS457-CYS476 | |
| A | CYS457-CYS476 | |
| B | CYS421-CYS441 | |
| B | CYS457-CYS476 | |
| C | CYS421-CYS441 | |
| C | CYS457-CYS476 | |
| D | CYS421-CYS441 | |
| D | CYS457-CYS476 | |
| E | CYS421-CYS441 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:19141540 |
| Chain | Residue | Details |
| A | LYS480 | |
| C | LYS492 | |
| C | LYS494 | |
| C | LYS495 | |
| D | LYS480 | |
| D | LYS492 | |
| D | LYS494 | |
| D | LYS495 | |
| E | LYS480 | |
| E | LYS492 | |
| E | LYS494 | |
| A | LYS492 | |
| E | LYS495 | |
| F | LYS480 | |
| F | LYS492 | |
| F | LYS494 | |
| F | LYS495 | |
| G | LYS480 | |
| G | LYS492 | |
| G | LYS494 | |
| G | LYS495 | |
| H | LYS480 | |
| A | LYS494 | |
| H | LYS492 | |
| H | LYS494 | |
| H | LYS495 | |
| A | LYS495 | |
| B | LYS480 | |
| B | LYS492 | |
| B | LYS494 | |
| B | LYS495 | |
| C | LYS480 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P06537 |
| Chain | Residue | Details |
| A | LYS419 | |
| F | LYS419 | |
| G | LYS419 | |
| H | LYS419 | |
| B | LYS419 | |
| C | LYS419 | |
| D | LYS419 | |
| E | LYS419 |
