6CEP
Sus scrofa heart L-lactate dehydrogenase ternary complex with NADH and oxamate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0006089 | biological_process | lactate metabolic process |
A | 0006090 | biological_process | pyruvate metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0003824 | molecular_function | catalytic activity |
B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005743 | cellular_component | mitochondrial inner membrane |
B | 0006089 | biological_process | lactate metabolic process |
B | 0006090 | biological_process | pyruvate metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0019752 | biological_process | carboxylic acid metabolic process |
C | 0003824 | molecular_function | catalytic activity |
C | 0004459 | molecular_function | L-lactate dehydrogenase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005739 | cellular_component | mitochondrion |
C | 0005743 | cellular_component | mitochondrial inner membrane |
C | 0006089 | biological_process | lactate metabolic process |
C | 0006090 | biological_process | pyruvate metabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0019752 | biological_process | carboxylic acid metabolic process |
D | 0003824 | molecular_function | catalytic activity |
D | 0004459 | molecular_function | L-lactate dehydrogenase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005739 | cellular_component | mitochondrion |
D | 0005743 | cellular_component | mitochondrial inner membrane |
D | 0006089 | biological_process | lactate metabolic process |
D | 0006090 | biological_process | pyruvate metabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 30 |
Details | binding site for residue NAD A 401 |
Chain | Residue |
A | GLY29 |
A | VAL98 |
A | ARG99 |
A | VAL116 |
A | ILE120 |
A | VAL136 |
A | ASN138 |
A | SER161 |
A | LEU165 |
A | HIS193 |
A | THR248 |
A | GLN30 |
A | ILE252 |
A | OXM402 |
A | HOH512 |
A | HOH520 |
A | HOH521 |
A | HOH532 |
A | HOH551 |
A | HOH567 |
A | HOH572 |
A | HOH581 |
A | VAL31 |
A | HOH608 |
A | ASP52 |
A | VAL53 |
A | LEU54 |
A | THR95 |
A | ALA96 |
A | GLY97 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue OXM A 402 |
Chain | Residue |
A | GLN100 |
A | ARG106 |
A | ASN138 |
A | ARG169 |
A | HIS193 |
A | ALA238 |
A | THR248 |
A | NAD401 |
site_id | AC3 |
Number of Residues | 28 |
Details | binding site for residue NAD B 401 |
Chain | Residue |
A | ASN108 |
B | GLY29 |
B | GLN30 |
B | VAL31 |
B | ASP52 |
B | VAL53 |
B | LEU54 |
B | THR95 |
B | ALA96 |
B | GLY97 |
B | VAL98 |
B | ARG99 |
B | VAL116 |
B | ILE120 |
B | VAL136 |
B | ASN138 |
B | SER161 |
B | HIS193 |
B | THR248 |
B | ILE252 |
B | OXM402 |
B | HOH503 |
B | HOH510 |
B | HOH538 |
B | HOH547 |
B | HOH567 |
B | HOH571 |
B | HOH600 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue OXM B 402 |
Chain | Residue |
B | ASN138 |
B | LEU165 |
B | ARG169 |
B | HIS193 |
B | ALA238 |
B | THR248 |
B | NAD401 |
B | HOH508 |
site_id | AC5 |
Number of Residues | 27 |
Details | binding site for residue NAD C 401 |
Chain | Residue |
C | HOH551 |
C | HOH564 |
C | GLY29 |
C | GLN30 |
C | VAL31 |
C | ASP52 |
C | VAL53 |
C | LEU54 |
C | THR95 |
C | ALA96 |
C | GLY97 |
C | VAL98 |
C | ARG99 |
C | VAL116 |
C | VAL136 |
C | ASN138 |
C | SER161 |
C | LEU165 |
C | HIS193 |
C | THR248 |
C | ILE252 |
C | OXM402 |
C | HOH511 |
C | HOH513 |
C | HOH521 |
C | HOH544 |
C | HOH545 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue OXM C 402 |
Chain | Residue |
C | GLN100 |
C | ARG106 |
C | ASN138 |
C | ARG169 |
C | HIS193 |
C | ALA238 |
C | THR248 |
C | NAD401 |
site_id | AC7 |
Number of Residues | 30 |
Details | binding site for residue NAD D 401 |
Chain | Residue |
D | GLY29 |
D | GLN30 |
D | VAL31 |
D | ASP52 |
D | VAL53 |
D | LEU54 |
D | THR95 |
D | ALA96 |
D | GLY97 |
D | VAL98 |
D | PHE119 |
D | ILE120 |
D | VAL136 |
D | ASN138 |
D | SER161 |
D | HIS193 |
D | THR248 |
D | ILE252 |
D | OXM402 |
D | HOH505 |
D | HOH510 |
D | HOH522 |
D | HOH548 |
D | HOH564 |
D | HOH569 |
D | HOH589 |
D | HOH590 |
D | HOH611 |
D | HOH628 |
D | HOH630 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue OXM D 402 |
Chain | Residue |
D | ASN138 |
D | ARG169 |
D | HIS193 |
D | ALA238 |
D | THR248 |
D | NAD401 |
Functional Information from PROSITE/UniProt
site_id | PS00064 |
Number of Residues | 7 |
Details | L_LDH L-lactate dehydrogenase active site. LGEHGDS |
Chain | Residue | Details |
A | LEU190-SER196 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000250 |
Chain | Residue | Details |
A | HIS193 | |
B | HIS193 | |
C | HIS193 | |
D | HIS193 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | GLY29 | |
B | ASN138 | |
B | ARG169 | |
B | THR248 | |
C | GLY29 | |
C | ARG99 | |
C | ARG106 | |
C | ASN138 | |
C | ARG169 | |
C | THR248 | |
D | GLY29 | |
A | ARG99 | |
D | ARG99 | |
D | ARG106 | |
D | ASN138 | |
D | ARG169 | |
D | THR248 | |
A | ARG106 | |
A | ASN138 | |
A | ARG169 | |
A | THR248 | |
B | GLY29 | |
B | ARG99 | |
B | ARG106 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:838465 |
Chain | Residue | Details |
A | ALA1 | |
B | ALA1 | |
C | ALA1 | |
D | ALA1 |
site_id | SWS_FT_FI4 |
Number of Residues | 16 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P07195 |
Chain | Residue | Details |
A | LYS6 | |
C | LYS57 | |
C | LYS118 | |
C | LYS328 | |
D | LYS6 | |
D | LYS57 | |
D | LYS118 | |
D | LYS328 | |
A | LYS57 | |
A | LYS118 | |
A | LYS328 | |
B | LYS6 | |
B | LYS57 | |
B | LYS118 | |
B | LYS328 | |
C | LYS6 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07195 |
Chain | Residue | Details |
A | SER43 | |
B | SER43 | |
C | SER43 | |
D | SER43 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P07195 |
Chain | Residue | Details |
A | TYR239 | |
B | TYR239 | |
C | TYR239 | |
D | TYR239 |