6CEP
Sus scrofa heart L-lactate dehydrogenase ternary complex with NADH and oxamate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005743 | cellular_component | mitochondrial inner membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005743 | cellular_component | mitochondrial inner membrane |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | GLY29 |
| A | VAL98 |
| A | ARG99 |
| A | VAL116 |
| A | ILE120 |
| A | VAL136 |
| A | ASN138 |
| A | SER161 |
| A | LEU165 |
| A | HIS193 |
| A | THR248 |
| A | GLN30 |
| A | ILE252 |
| A | OXM402 |
| A | HOH512 |
| A | HOH520 |
| A | HOH521 |
| A | HOH532 |
| A | HOH551 |
| A | HOH567 |
| A | HOH572 |
| A | HOH581 |
| A | VAL31 |
| A | HOH608 |
| A | ASP52 |
| A | VAL53 |
| A | LEU54 |
| A | THR95 |
| A | ALA96 |
| A | GLY97 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue OXM A 402 |
| Chain | Residue |
| A | GLN100 |
| A | ARG106 |
| A | ASN138 |
| A | ARG169 |
| A | HIS193 |
| A | ALA238 |
| A | THR248 |
| A | NAD401 |
| site_id | AC3 |
| Number of Residues | 28 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| A | ASN108 |
| B | GLY29 |
| B | GLN30 |
| B | VAL31 |
| B | ASP52 |
| B | VAL53 |
| B | LEU54 |
| B | THR95 |
| B | ALA96 |
| B | GLY97 |
| B | VAL98 |
| B | ARG99 |
| B | VAL116 |
| B | ILE120 |
| B | VAL136 |
| B | ASN138 |
| B | SER161 |
| B | HIS193 |
| B | THR248 |
| B | ILE252 |
| B | OXM402 |
| B | HOH503 |
| B | HOH510 |
| B | HOH538 |
| B | HOH547 |
| B | HOH567 |
| B | HOH571 |
| B | HOH600 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue OXM B 402 |
| Chain | Residue |
| B | ASN138 |
| B | LEU165 |
| B | ARG169 |
| B | HIS193 |
| B | ALA238 |
| B | THR248 |
| B | NAD401 |
| B | HOH508 |
| site_id | AC5 |
| Number of Residues | 27 |
| Details | binding site for residue NAD C 401 |
| Chain | Residue |
| C | HOH551 |
| C | HOH564 |
| C | GLY29 |
| C | GLN30 |
| C | VAL31 |
| C | ASP52 |
| C | VAL53 |
| C | LEU54 |
| C | THR95 |
| C | ALA96 |
| C | GLY97 |
| C | VAL98 |
| C | ARG99 |
| C | VAL116 |
| C | VAL136 |
| C | ASN138 |
| C | SER161 |
| C | LEU165 |
| C | HIS193 |
| C | THR248 |
| C | ILE252 |
| C | OXM402 |
| C | HOH511 |
| C | HOH513 |
| C | HOH521 |
| C | HOH544 |
| C | HOH545 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue OXM C 402 |
| Chain | Residue |
| C | GLN100 |
| C | ARG106 |
| C | ASN138 |
| C | ARG169 |
| C | HIS193 |
| C | ALA238 |
| C | THR248 |
| C | NAD401 |
| site_id | AC7 |
| Number of Residues | 30 |
| Details | binding site for residue NAD D 401 |
| Chain | Residue |
| D | GLY29 |
| D | GLN30 |
| D | VAL31 |
| D | ASP52 |
| D | VAL53 |
| D | LEU54 |
| D | THR95 |
| D | ALA96 |
| D | GLY97 |
| D | VAL98 |
| D | PHE119 |
| D | ILE120 |
| D | VAL136 |
| D | ASN138 |
| D | SER161 |
| D | HIS193 |
| D | THR248 |
| D | ILE252 |
| D | OXM402 |
| D | HOH505 |
| D | HOH510 |
| D | HOH522 |
| D | HOH548 |
| D | HOH564 |
| D | HOH569 |
| D | HOH589 |
| D | HOH590 |
| D | HOH611 |
| D | HOH628 |
| D | HOH630 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue OXM D 402 |
| Chain | Residue |
| D | ASN138 |
| D | ARG169 |
| D | HIS193 |
| D | ALA238 |
| D | THR248 |
| D | NAD401 |
Functional Information from PROSITE/UniProt
| site_id | PS00064 |
| Number of Residues | 7 |
| Details | L_LDH L-lactate dehydrogenase active site. LGEHGDS |
| Chain | Residue | Details |
| A | LEU190-SER196 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 129 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"838465","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P07195","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07195","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P07195","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
