6CE7

Insulin Receptor ectodomain in complex with one insulin molecule

Functional Information from GO Data

Chain	GOid	namespace	contents
N	0005179	molecular_function	hormone activity
N	0005576	cellular_component	extracellular region
O	0005179	molecular_function	hormone activity
O	0005576	cellular_component	extracellular region

Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCTSiCSlyqLenyC

Chain	Residue	Details
N	CYS6-CYS20

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1846
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
B	HIS1-SER640
B	SER640-LYS917
A	HIS1-SER731
A	SER736-LYS929

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Insulin-binding => ECO:0000305

Chain	Residue	Details
B	PHE39
A	PHE39

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
B	SER373
B	SER380
A	SER373
A	SER380

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
B	TYR374
A	TYR374

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862, ECO:0000269|PubMed:2983222

Chain	Residue	Details
B	ASN16
A	ASN16

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site_id	SWS_FT_FI6
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862

Chain	Residue	Details
B	ASN25
B	ASN111
B	ASN255
A	ASN25
A	ASN111
A	ASN255

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site_id	SWS_FT_FI7
Number of Residues	14
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN78
A	ASN606
A	ASN624
A	ASN671
A	ASN755
A	ASN906
B	ASN295
B	ASN606
B	ASN624
B	ASN638
B	ASN641
B	ASN894
A	ASN78
A	ASN295

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site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:23302862

Chain	Residue	Details
B	ASN215
A	ASN215

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site_id	SWS_FT_FI9
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147

Chain	Residue	Details
B	ASN337
B	ASN397
A	ASN337
A	ASN397

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site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:19349973

Chain	Residue	Details
B	ASN418
A	ASN418

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site_id	SWS_FT_FI11
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1472036, ECO:0000269|PubMed:19159218

Chain	Residue	Details
B	ASN514
A	ASN514

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site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2983222

Chain	Residue	Details
B	ASN641
A	ASN742

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site_id	SWS_FT_FI13
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
B	ASN881
A	ASN893

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 246

Chain

Residue

Details

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site_id	MCSA2
Number of Residues
Details	M-CSA 246

Chain

Residue

Details

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