6C9A
Cryo-EM structure of mouse TPC1 channel in the PtdIns(3,5)P2-bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005768 | cellular_component | endosome |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0010508 | biological_process | positive regulation of autophagy |
| A | 0015280 | molecular_function | ligand-gated sodium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0019905 | molecular_function | syntaxin binding |
| A | 0022832 | molecular_function | voltage-gated channel activity |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0036019 | cellular_component | endolysosome |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0072345 | molecular_function | NAADP-sensitive calcium-release channel activity |
| A | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| A | 0080025 | molecular_function | phosphatidylinositol-3,5-bisphosphate binding |
| A | 0097682 | molecular_function | intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005248 | molecular_function | voltage-gated sodium channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005764 | cellular_component | lysosome |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005768 | cellular_component | endosome |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0010508 | biological_process | positive regulation of autophagy |
| B | 0015280 | molecular_function | ligand-gated sodium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019722 | biological_process | calcium-mediated signaling |
| B | 0019905 | molecular_function | syntaxin binding |
| B | 0022832 | molecular_function | voltage-gated channel activity |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0034702 | cellular_component | monoatomic ion channel complex |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0036019 | cellular_component | endolysosome |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0055038 | cellular_component | recycling endosome membrane |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0072345 | molecular_function | NAADP-sensitive calcium-release channel activity |
| B | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| B | 0080025 | molecular_function | phosphatidylinositol-3,5-bisphosphate binding |
| B | 0097682 | molecular_function | intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity |
Functional Information from PROSITE/UniProt
| site_id | PS00307 |
| Number of Residues | 7 |
| Details | LECTIN_LEGUME_BETA Legume lectins beta-chain signature. LAVVFDT |
| Chain | Residue | Details |
| B | LEU317-THR323 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 814 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | MET1-GLU113 | |
| B | LYS159-LYS172 | |
| B | ASN222-ASP235 | |
| B | VAL320-GLN445 | |
| B | GLU502-LEU504 | |
| B | LYS551-ALA569 | |
| B | PHE693-THR817 | |
| A | MET1-GLU113 | |
| A | LYS159-LYS172 | |
| A | ASN222-ASP235 | |
| A | VAL320-GLN445 | |
| A | GLU502-LEU504 | |
| A | LYS551-ALA569 | |
| A | PHE693-THR817 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU114-LEU134 | |
| A | LEU114-LEU134 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 202 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | LYS135-HIS137 | |
| B | ARG194-THR202 | |
| B | THR257-TYR263 | |
| B | MET288-CYS298 | |
| B | LYS467-TYR480 | |
| B | LEU528-PHE535 | |
| B | ASN591-ASN630 | |
| B | GLU655-THR671 | |
| A | LYS135-HIS137 | |
| A | ARG194-THR202 | |
| A | THR257-TYR263 | |
| A | MET288-CYS298 | |
| A | LYS467-TYR480 | |
| A | LEU528-PHE535 | |
| A | ASN591-ASN630 | |
| A | GLU655-THR671 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| B | THR138-MET158 | |
| A | THR138-MET158 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| B | ARG173-VAL193 | |
| A | ARG173-VAL193 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| B | ARG203-ARG221 | |
| A | ARG203-ARG221 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| B | ILE236-SER256 | |
| A | ILE236-SER256 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 92 |
| Details | INTRAMEM: Helical; Pore-forming => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE264-MET287 | |
| B | PHE631-MET654 | |
| A | PHE264-MET287 | |
| A | PHE631-MET654 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| B | VAL299-VAL319 | |
| A | VAL299-VAL319 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| B | TYR446-LEU466 | |
| A | TYR446-LEU466 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU481-VAL501 | |
| A | LEU481-VAL501 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| B | SER505-THR527 | |
| A | SER505-THR527 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| B | ILE536-LEU550 | |
| A | ILE536-LEU550 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| B | SER570-PHE590 | |
| A | SER570-PHE590 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE672-VAL692 | |
| A | PHE672-VAL692 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN470 | |
| A | ASN470 |
