6C96
Cryo-EM structure of mouse TPC1 channel in the apo state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0010508 | biological_process | positive regulation of autophagy |
| A | 0015280 | molecular_function | ligand-gated sodium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0019905 | molecular_function | syntaxin binding |
| A | 0022832 | molecular_function | voltage-gated channel activity |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0036019 | cellular_component | endolysosome |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0072345 | molecular_function | NAADP-sensitive calcium-release channel activity |
| A | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| A | 0080025 | molecular_function | phosphatidylinositol-3,5-bisphosphate binding |
| A | 0097682 | molecular_function | intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005248 | molecular_function | voltage-gated sodium channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006816 | biological_process | calcium ion transport |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0010508 | biological_process | positive regulation of autophagy |
| B | 0015280 | molecular_function | ligand-gated sodium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019722 | biological_process | calcium-mediated signaling |
| B | 0019905 | molecular_function | syntaxin binding |
| B | 0022832 | molecular_function | voltage-gated channel activity |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0034702 | cellular_component | monoatomic ion channel complex |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0036019 | cellular_component | endolysosome |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0055038 | cellular_component | recycling endosome membrane |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0072345 | molecular_function | NAADP-sensitive calcium-release channel activity |
| B | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| B | 0080025 | molecular_function | phosphatidylinositol-3,5-bisphosphate binding |
| B | 0097682 | molecular_function | intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity |
Functional Information from PROSITE/UniProt
| site_id | PS00307 |
| Number of Residues | 7 |
| Details | LECTIN_LEGUME_BETA Legume lectins beta-chain signature. LAVVFDT |
| Chain | Residue | Details |
| A | LEU317-THR323 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 202 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 342 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 92 |
| Details | Intramembrane: {"description":"Helical; Pore-forming","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=S4 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 48 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
