6C93
Effects of the E310A Mutation of Cytochrome P450 4B1 (CYP4B1) on n-Octane binding and Heme Ruffling
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0016712 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| A | 0019395 | biological_process | fatty acid oxidation |
| A | 0020037 | molecular_function | heme binding |
| A | 0120252 | biological_process | hydrocarbon metabolic process |
| A | 0120502 | molecular_function | fatty acid omega-1 hydroxylase activity |
| A | 0120503 | molecular_function | medium-chain fatty acid omega-1 hydroxylase activity |
| A | 0140981 | molecular_function | medium-chain fatty acid omega-hydroxylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue HEM A 600 |
| Chain | Residue |
| A | LYS105 |
| A | THR314 |
| A | PRO374 |
| A | VAL375 |
| A | VAL378 |
| A | PRO440 |
| A | PHE441 |
| A | ARG446 |
| A | ASN447 |
| A | CYS448 |
| A | PHE453 |
| A | TYR110 |
| A | ALA454 |
| A | MET458 |
| A | OCT601 |
| A | HOH702 |
| A | HOH705 |
| A | LEU121 |
| A | LEU122 |
| A | TRP129 |
| A | ARG133 |
| A | PHE140 |
| A | ALA310 |
| A | GLY311 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue OCT A 601 |
| Chain | Residue |
| A | VAL109 |
| A | ALA310 |
| A | THR314 |
| A | GLN377 |
| A | HEM600 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSaGPRNCIG |
| Chain | Residue | Details |
| A | PHE441-GLY450 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28167536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29858244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5T6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C93","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C94","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"28167536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29858244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5T6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C94","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"28167536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29858244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5T6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C93","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C94","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P20816","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
