6C5A
Human UDP-Glucose Dehydrogenase with UDP- Glc and NADH bound
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001702 | biological_process | gastrulation with mouth forming second |
A | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
A | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
A | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
A | 0034214 | biological_process | protein hexamerization |
A | 0042802 | molecular_function | identical protein binding |
A | 0048666 | biological_process | neuron development |
A | 0051287 | molecular_function | NAD binding |
A | 0070062 | cellular_component | extracellular exosome |
B | 0001702 | biological_process | gastrulation with mouth forming second |
B | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
B | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
B | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
B | 0034214 | biological_process | protein hexamerization |
B | 0042802 | molecular_function | identical protein binding |
B | 0048666 | biological_process | neuron development |
B | 0051287 | molecular_function | NAD binding |
B | 0070062 | cellular_component | extracellular exosome |
C | 0001702 | biological_process | gastrulation with mouth forming second |
C | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
C | 0005634 | cellular_component | nucleus |
C | 0005654 | cellular_component | nucleoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
C | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
C | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
C | 0034214 | biological_process | protein hexamerization |
C | 0042802 | molecular_function | identical protein binding |
C | 0048666 | biological_process | neuron development |
C | 0051287 | molecular_function | NAD binding |
C | 0070062 | cellular_component | extracellular exosome |
D | 0001702 | biological_process | gastrulation with mouth forming second |
D | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
D | 0005634 | cellular_component | nucleus |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
D | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
D | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
D | 0034214 | biological_process | protein hexamerization |
D | 0042802 | molecular_function | identical protein binding |
D | 0048666 | biological_process | neuron development |
D | 0051287 | molecular_function | NAD binding |
D | 0070062 | cellular_component | extracellular exosome |
E | 0001702 | biological_process | gastrulation with mouth forming second |
E | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
E | 0005634 | cellular_component | nucleus |
E | 0005654 | cellular_component | nucleoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
E | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
E | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
E | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
E | 0034214 | biological_process | protein hexamerization |
E | 0042802 | molecular_function | identical protein binding |
E | 0048666 | biological_process | neuron development |
E | 0051287 | molecular_function | NAD binding |
E | 0070062 | cellular_component | extracellular exosome |
F | 0001702 | biological_process | gastrulation with mouth forming second |
F | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
F | 0005634 | cellular_component | nucleus |
F | 0005654 | cellular_component | nucleoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
F | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
F | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
F | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
F | 0034214 | biological_process | protein hexamerization |
F | 0042802 | molecular_function | identical protein binding |
F | 0048666 | biological_process | neuron development |
F | 0051287 | molecular_function | NAD binding |
F | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | binding site for residue NAI A 501 |
Chain | Residue |
A | ILE10 |
A | VAL89 |
A | ASN90 |
A | THR91 |
A | TYR108 |
A | SER130 |
A | THR131 |
A | GLU161 |
A | GLU165 |
A | CYS276 |
A | LYS279 |
A | GLY11 |
A | ARG346 |
A | UPG502 |
A | HOH613 |
A | HOH616 |
A | HOH639 |
A | HOH666 |
A | GLY13 |
A | TYR14 |
A | VAL15 |
A | ASP36 |
A | VAL37 |
A | ARG41 |
A | SER88 |
site_id | AC2 |
Number of Residues | 29 |
Details | binding site for residue UPG A 502 |
Chain | Residue |
A | GLU161 |
A | PHE162 |
A | LEU163 |
A | ALA164 |
A | GLU165 |
A | LYS220 |
A | ASN224 |
A | ILE231 |
A | PHE265 |
A | LEU266 |
A | LYS267 |
A | SER269 |
A | PHE272 |
A | GLY273 |
A | CYS276 |
A | PHE277 |
A | PHE338 |
A | LYS339 |
A | ARG442 |
A | NAI501 |
A | HOH616 |
A | HOH620 |
A | HOH625 |
A | HOH655 |
A | HOH664 |
A | HOH673 |
A | HOH678 |
A | HOH684 |
B | ARG260 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue DMS A 503 |
Chain | Residue |
A | PHE162 |
A | ASP171 |
A | ASP176 |
B | ASP258 |
B | ARG260 |
site_id | AC4 |
Number of Residues | 28 |
Details | binding site for residue NAI B 501 |
Chain | Residue |
B | ILE10 |
B | GLY11 |
B | GLY13 |
B | TYR14 |
B | VAL15 |
B | ASP36 |
B | VAL37 |
B | ARG41 |
B | SER88 |
B | VAL89 |
B | ASN90 |
B | THR91 |
B | TYR108 |
B | SER130 |
B | THR131 |
B | GLU161 |
B | LEU163 |
B | GLU165 |
B | CYS276 |
B | LYS279 |
B | ARG346 |
B | UPG502 |
B | HOH625 |
B | HOH629 |
B | HOH632 |
B | HOH644 |
B | HOH687 |
B | HOH692 |
site_id | AC5 |
Number of Residues | 28 |
Details | binding site for residue UPG B 502 |
Chain | Residue |
B | LYS267 |
B | SER269 |
B | PHE272 |
B | GLY273 |
B | CYS276 |
B | PHE277 |
B | ASP280 |
B | PHE338 |
B | LYS339 |
B | ARG442 |
B | NAI501 |
B | HOH625 |
B | HOH629 |
B | HOH638 |
B | HOH639 |
B | HOH688 |
A | ARG260 |
A | HOH667 |
B | GLU161 |
B | PHE162 |
B | LEU163 |
B | ALA164 |
B | GLU165 |
B | LYS220 |
B | ASN224 |
B | ILE231 |
B | PHE265 |
B | LEU266 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue DMS B 503 |
Chain | Residue |
A | ASP258 |
A | ARG260 |
B | PHE162 |
B | ASP171 |
B | ASP176 |
B | HOH622 |
site_id | AC7 |
Number of Residues | 28 |
Details | binding site for residue NAI C 501 |
Chain | Residue |
C | ILE10 |
C | GLY11 |
C | GLY13 |
C | TYR14 |
C | VAL15 |
C | ASP36 |
C | VAL37 |
C | ARG41 |
C | SER88 |
C | VAL89 |
C | ASN90 |
C | THR91 |
C | TYR108 |
C | SER130 |
C | THR131 |
C | GLU161 |
C | LEU163 |
C | GLU165 |
C | CYS276 |
C | LYS279 |
C | ARG346 |
C | UPG502 |
C | HOH640 |
C | HOH642 |
C | HOH672 |
C | HOH673 |
C | HOH695 |
C | HOH701 |
site_id | AC8 |
Number of Residues | 28 |
Details | binding site for residue UPG C 502 |
Chain | Residue |
C | GLU161 |
C | PHE162 |
C | LEU163 |
C | ALA164 |
C | GLU165 |
C | LYS220 |
C | ASN224 |
C | ILE231 |
C | PHE265 |
C | LEU266 |
C | LYS267 |
C | SER269 |
C | PHE272 |
C | GLY273 |
C | CYS276 |
C | PHE277 |
C | PHE338 |
C | LYS339 |
C | ARG442 |
C | NAI501 |
C | HOH636 |
C | HOH640 |
C | HOH642 |
C | HOH645 |
C | HOH663 |
C | HOH683 |
C | HOH691 |
D | ARG260 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue DMS C 503 |
Chain | Residue |
C | PHE162 |
C | ASP171 |
C | HOH692 |
D | ASP258 |
D | ARG260 |
site_id | AD1 |
Number of Residues | 25 |
Details | binding site for residue NAI D 500 |
Chain | Residue |
D | ILE10 |
D | GLY11 |
D | GLY13 |
D | TYR14 |
D | VAL15 |
D | ASP36 |
D | VAL37 |
D | ASN38 |
D | ARG41 |
D | SER88 |
D | VAL89 |
D | ASN90 |
D | THR91 |
D | TYR108 |
D | ALA111 |
D | SER130 |
D | THR131 |
D | GLU161 |
D | GLU165 |
D | CYS276 |
D | LYS279 |
D | ARG346 |
D | UPG501 |
D | HOH627 |
D | HOH630 |
site_id | AD2 |
Number of Residues | 24 |
Details | binding site for residue UPG D 501 |
Chain | Residue |
C | ARG260 |
D | GLU161 |
D | PHE162 |
D | LEU163 |
D | ALA164 |
D | GLU165 |
D | LYS220 |
D | ASN224 |
D | LEU227 |
D | ILE231 |
D | PHE265 |
D | LEU266 |
D | LYS267 |
D | SER269 |
D | PHE272 |
D | GLY273 |
D | CYS276 |
D | PHE277 |
D | PHE338 |
D | LYS339 |
D | ARG442 |
D | NAI500 |
D | HOH630 |
D | HOH654 |
site_id | AD3 |
Number of Residues | 19 |
Details | binding site for residue NAI E 500 |
Chain | Residue |
E | ILE10 |
E | GLY11 |
E | GLY13 |
E | TYR14 |
E | VAL15 |
E | ASP36 |
E | VAL37 |
E | ARG41 |
E | VAL89 |
E | ASN90 |
E | THR91 |
E | TYR108 |
E | SER130 |
E | THR131 |
E | GLU161 |
E | GLU165 |
E | CYS276 |
E | LYS279 |
E | UPG501 |
site_id | AD4 |
Number of Residues | 21 |
Details | binding site for residue UPG E 501 |
Chain | Residue |
E | PHE162 |
E | LEU163 |
E | GLU165 |
E | LYS220 |
E | ASN224 |
E | ILE231 |
E | PHE265 |
E | LEU266 |
E | LYS267 |
E | SER269 |
E | PHE272 |
E | GLY273 |
E | CYS276 |
E | PHE277 |
E | PHE338 |
E | LYS339 |
E | ARG442 |
E | NAI500 |
E | HOH613 |
E | HOH623 |
F | ARG260 |
site_id | AD5 |
Number of Residues | 30 |
Details | binding site for residue NAI F 501 |
Chain | Residue |
F | ILE10 |
F | GLY11 |
F | GLY13 |
F | TYR14 |
F | VAL15 |
F | ASP36 |
F | VAL37 |
F | ARG41 |
F | ILE75 |
F | SER88 |
F | VAL89 |
F | ASN90 |
F | THR91 |
F | TYR108 |
F | SER130 |
F | THR131 |
F | GLU161 |
F | LEU163 |
F | GLU165 |
F | CYS276 |
F | LYS279 |
F | ARG346 |
F | UPG502 |
F | HOH639 |
F | HOH643 |
F | HOH651 |
F | HOH657 |
F | HOH679 |
F | HOH692 |
F | HOH705 |
site_id | AD6 |
Number of Residues | 28 |
Details | binding site for residue UPG F 502 |
Chain | Residue |
E | ARG260 |
F | GLU161 |
F | PHE162 |
F | LEU163 |
F | ALA164 |
F | GLU165 |
F | LYS220 |
F | ASN224 |
F | ILE231 |
F | PHE265 |
F | LEU266 |
F | LYS267 |
F | SER269 |
F | PHE272 |
F | GLY273 |
F | CYS276 |
F | PHE277 |
F | PHE338 |
F | LYS339 |
F | ARG442 |
F | NAI501 |
F | HOH628 |
F | HOH638 |
F | HOH651 |
F | HOH655 |
F | HOH657 |
F | HOH664 |
F | HOH682 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue DMS F 503 |
Chain | Residue |
E | ASP258 |
E | ARG260 |
F | PHE162 |
F | ASP171 |
F | ASP176 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:22123821 |
Chain | Residue | Details |
A | GLU161 | |
E | LYS220 | |
F | GLU161 | |
F | LYS220 | |
A | LYS220 | |
B | GLU161 | |
B | LYS220 | |
C | GLU161 | |
C | LYS220 | |
D | GLU161 | |
D | LYS220 | |
E | GLU161 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821 |
Chain | Residue | Details |
A | CYS276 | |
B | CYS276 | |
C | CYS276 | |
D | CYS276 | |
E | CYS276 | |
F | CYS276 |
site_id | SWS_FT_FI3 |
Number of Residues | 30 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK |
Chain | Residue | Details |
A | GLY11 | |
B | CYS276 | |
C | GLY11 | |
C | ASP36 | |
C | ARG41 | |
C | VAL89 | |
C | CYS276 | |
D | GLY11 | |
D | ASP36 | |
D | ARG41 | |
D | VAL89 | |
A | ASP36 | |
D | CYS276 | |
E | GLY11 | |
E | ASP36 | |
E | ARG41 | |
E | VAL89 | |
E | CYS276 | |
F | GLY11 | |
F | ASP36 | |
F | ARG41 | |
F | VAL89 | |
A | ARG41 | |
F | CYS276 | |
A | VAL89 | |
A | CYS276 | |
B | GLY11 | |
B | ASP36 | |
B | ARG41 | |
B | VAL89 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445 |
Chain | Residue | Details |
A | SER130 | |
B | SER130 | |
C | SER130 | |
D | SER130 | |
E | SER130 | |
F | SER130 |
site_id | SWS_FT_FI5 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF |
Chain | Residue | Details |
A | GLU161 | |
C | LYS220 | |
C | LYS267 | |
C | PHE338 | |
D | GLU161 | |
D | LYS220 | |
D | LYS267 | |
D | PHE338 | |
E | GLU161 | |
E | LYS220 | |
E | LYS267 | |
A | LYS220 | |
E | PHE338 | |
F | GLU161 | |
F | LYS220 | |
F | LYS267 | |
F | PHE338 | |
A | LYS267 | |
A | PHE338 | |
B | GLU161 | |
B | LYS220 | |
B | LYS267 | |
B | PHE338 | |
C | GLU161 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4 |
Chain | Residue | Details |
A | GLU165 | |
B | GLU165 | |
C | GLU165 | |
D | GLU165 | |
E | GLU165 | |
F | GLU165 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH |
Chain | Residue | Details |
A | ARG260 | |
B | ARG260 | |
C | ARG260 | |
D | ARG260 | |
E | ARG260 | |
F | ARG260 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK |
Chain | Residue | Details |
A | ARG346 | |
B | ARG346 | |
C | ARG346 | |
D | ARG346 | |
E | ARG346 | |
F | ARG346 |
site_id | SWS_FT_FI9 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF |
Chain | Residue | Details |
A | ARG442 | |
B | ARG442 | |
C | ARG442 | |
D | ARG442 | |
E | ARG442 | |
F | ARG442 |
site_id | SWS_FT_FI10 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS107 | |
B | LYS107 | |
C | LYS107 | |
D | LYS107 | |
E | LYS107 | |
F | LYS107 |
site_id | SWS_FT_FI11 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER476 | |
B | SER476 | |
C | SER476 | |
D | SER476 | |
E | SER476 | |
F | SER476 |