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6C5A

Human UDP-Glucose Dehydrogenase with UDP- Glc and NADH bound

Functional Information from GO Data
ChainGOidnamespacecontents
A0001702biological_processgastrulation with mouth forming second
A0003824molecular_functioncatalytic activity
A0003979molecular_functionUDP-glucose 6-dehydrogenase activity
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005829cellular_componentcytosol
A0006024biological_processglycosaminoglycan biosynthetic process
A0006065biological_processUDP-glucuronate biosynthetic process
A0008152biological_processmetabolic process
A0015012biological_processheparan sulfate proteoglycan biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0030206biological_processchondroitin sulfate biosynthetic process
A0034214biological_processprotein hexamerization
A0042802molecular_functionidentical protein binding
A0048666biological_processneuron development
A0051287molecular_functionNAD binding
A0070062cellular_componentextracellular exosome
B0001702biological_processgastrulation with mouth forming second
B0003824molecular_functioncatalytic activity
B0003979molecular_functionUDP-glucose 6-dehydrogenase activity
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005829cellular_componentcytosol
B0006024biological_processglycosaminoglycan biosynthetic process
B0006065biological_processUDP-glucuronate biosynthetic process
B0008152biological_processmetabolic process
B0015012biological_processheparan sulfate proteoglycan biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0030206biological_processchondroitin sulfate biosynthetic process
B0034214biological_processprotein hexamerization
B0042802molecular_functionidentical protein binding
B0048666biological_processneuron development
B0051287molecular_functionNAD binding
B0070062cellular_componentextracellular exosome
C0001702biological_processgastrulation with mouth forming second
C0003824molecular_functioncatalytic activity
C0003979molecular_functionUDP-glucose 6-dehydrogenase activity
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005829cellular_componentcytosol
C0006024biological_processglycosaminoglycan biosynthetic process
C0006065biological_processUDP-glucuronate biosynthetic process
C0008152biological_processmetabolic process
C0015012biological_processheparan sulfate proteoglycan biosynthetic process
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0030206biological_processchondroitin sulfate biosynthetic process
C0034214biological_processprotein hexamerization
C0042802molecular_functionidentical protein binding
C0048666biological_processneuron development
C0051287molecular_functionNAD binding
C0070062cellular_componentextracellular exosome
D0001702biological_processgastrulation with mouth forming second
D0003824molecular_functioncatalytic activity
D0003979molecular_functionUDP-glucose 6-dehydrogenase activity
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005829cellular_componentcytosol
D0006024biological_processglycosaminoglycan biosynthetic process
D0006065biological_processUDP-glucuronate biosynthetic process
D0008152biological_processmetabolic process
D0015012biological_processheparan sulfate proteoglycan biosynthetic process
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0030206biological_processchondroitin sulfate biosynthetic process
D0034214biological_processprotein hexamerization
D0042802molecular_functionidentical protein binding
D0048666biological_processneuron development
D0051287molecular_functionNAD binding
D0070062cellular_componentextracellular exosome
E0001702biological_processgastrulation with mouth forming second
E0003824molecular_functioncatalytic activity
E0003979molecular_functionUDP-glucose 6-dehydrogenase activity
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005829cellular_componentcytosol
E0006024biological_processglycosaminoglycan biosynthetic process
E0006065biological_processUDP-glucuronate biosynthetic process
E0008152biological_processmetabolic process
E0015012biological_processheparan sulfate proteoglycan biosynthetic process
E0016491molecular_functionoxidoreductase activity
E0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E0030206biological_processchondroitin sulfate biosynthetic process
E0034214biological_processprotein hexamerization
E0042802molecular_functionidentical protein binding
E0048666biological_processneuron development
E0051287molecular_functionNAD binding
E0070062cellular_componentextracellular exosome
F0001702biological_processgastrulation with mouth forming second
F0003824molecular_functioncatalytic activity
F0003979molecular_functionUDP-glucose 6-dehydrogenase activity
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005829cellular_componentcytosol
F0006024biological_processglycosaminoglycan biosynthetic process
F0006065biological_processUDP-glucuronate biosynthetic process
F0008152biological_processmetabolic process
F0015012biological_processheparan sulfate proteoglycan biosynthetic process
F0016491molecular_functionoxidoreductase activity
F0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F0030206biological_processchondroitin sulfate biosynthetic process
F0034214biological_processprotein hexamerization
F0042802molecular_functionidentical protein binding
F0048666biological_processneuron development
F0051287molecular_functionNAD binding
F0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues25
Detailsbinding site for residue NAI A 501
ChainResidue
AILE10
AVAL89
AASN90
ATHR91
ATYR108
ASER130
ATHR131
AGLU161
AGLU165
ACYS276
ALYS279
AGLY11
AARG346
AUPG502
AHOH613
AHOH616
AHOH639
AHOH666
AGLY13
ATYR14
AVAL15
AASP36
AVAL37
AARG41
ASER88

site_idAC2
Number of Residues29
Detailsbinding site for residue UPG A 502
ChainResidue
AGLU161
APHE162
ALEU163
AALA164
AGLU165
ALYS220
AASN224
AILE231
APHE265
ALEU266
ALYS267
ASER269
APHE272
AGLY273
ACYS276
APHE277
APHE338
ALYS339
AARG442
ANAI501
AHOH616
AHOH620
AHOH625
AHOH655
AHOH664
AHOH673
AHOH678
AHOH684
BARG260

site_idAC3
Number of Residues5
Detailsbinding site for residue DMS A 503
ChainResidue
APHE162
AASP171
AASP176
BASP258
BARG260

site_idAC4
Number of Residues28
Detailsbinding site for residue NAI B 501
ChainResidue
BILE10
BGLY11
BGLY13
BTYR14
BVAL15
BASP36
BVAL37
BARG41
BSER88
BVAL89
BASN90
BTHR91
BTYR108
BSER130
BTHR131
BGLU161
BLEU163
BGLU165
BCYS276
BLYS279
BARG346
BUPG502
BHOH625
BHOH629
BHOH632
BHOH644
BHOH687
BHOH692

site_idAC5
Number of Residues28
Detailsbinding site for residue UPG B 502
ChainResidue
BLYS267
BSER269
BPHE272
BGLY273
BCYS276
BPHE277
BASP280
BPHE338
BLYS339
BARG442
BNAI501
BHOH625
BHOH629
BHOH638
BHOH639
BHOH688
AARG260
AHOH667
BGLU161
BPHE162
BLEU163
BALA164
BGLU165
BLYS220
BASN224
BILE231
BPHE265
BLEU266

site_idAC6
Number of Residues6
Detailsbinding site for residue DMS B 503
ChainResidue
AASP258
AARG260
BPHE162
BASP171
BASP176
BHOH622

site_idAC7
Number of Residues28
Detailsbinding site for residue NAI C 501
ChainResidue
CILE10
CGLY11
CGLY13
CTYR14
CVAL15
CASP36
CVAL37
CARG41
CSER88
CVAL89
CASN90
CTHR91
CTYR108
CSER130
CTHR131
CGLU161
CLEU163
CGLU165
CCYS276
CLYS279
CARG346
CUPG502
CHOH640
CHOH642
CHOH672
CHOH673
CHOH695
CHOH701

site_idAC8
Number of Residues28
Detailsbinding site for residue UPG C 502
ChainResidue
CGLU161
CPHE162
CLEU163
CALA164
CGLU165
CLYS220
CASN224
CILE231
CPHE265
CLEU266
CLYS267
CSER269
CPHE272
CGLY273
CCYS276
CPHE277
CPHE338
CLYS339
CARG442
CNAI501
CHOH636
CHOH640
CHOH642
CHOH645
CHOH663
CHOH683
CHOH691
DARG260

site_idAC9
Number of Residues5
Detailsbinding site for residue DMS C 503
ChainResidue
CPHE162
CASP171
CHOH692
DASP258
DARG260

site_idAD1
Number of Residues25
Detailsbinding site for residue NAI D 500
ChainResidue
DILE10
DGLY11
DGLY13
DTYR14
DVAL15
DASP36
DVAL37
DASN38
DARG41
DSER88
DVAL89
DASN90
DTHR91
DTYR108
DALA111
DSER130
DTHR131
DGLU161
DGLU165
DCYS276
DLYS279
DARG346
DUPG501
DHOH627
DHOH630

site_idAD2
Number of Residues24
Detailsbinding site for residue UPG D 501
ChainResidue
CARG260
DGLU161
DPHE162
DLEU163
DALA164
DGLU165
DLYS220
DASN224
DLEU227
DILE231
DPHE265
DLEU266
DLYS267
DSER269
DPHE272
DGLY273
DCYS276
DPHE277
DPHE338
DLYS339
DARG442
DNAI500
DHOH630
DHOH654

site_idAD3
Number of Residues19
Detailsbinding site for residue NAI E 500
ChainResidue
EILE10
EGLY11
EGLY13
ETYR14
EVAL15
EASP36
EVAL37
EARG41
EVAL89
EASN90
ETHR91
ETYR108
ESER130
ETHR131
EGLU161
EGLU165
ECYS276
ELYS279
EUPG501

site_idAD4
Number of Residues21
Detailsbinding site for residue UPG E 501
ChainResidue
EPHE162
ELEU163
EGLU165
ELYS220
EASN224
EILE231
EPHE265
ELEU266
ELYS267
ESER269
EPHE272
EGLY273
ECYS276
EPHE277
EPHE338
ELYS339
EARG442
ENAI500
EHOH613
EHOH623
FARG260

site_idAD5
Number of Residues30
Detailsbinding site for residue NAI F 501
ChainResidue
FILE10
FGLY11
FGLY13
FTYR14
FVAL15
FASP36
FVAL37
FARG41
FILE75
FSER88
FVAL89
FASN90
FTHR91
FTYR108
FSER130
FTHR131
FGLU161
FLEU163
FGLU165
FCYS276
FLYS279
FARG346
FUPG502
FHOH639
FHOH643
FHOH651
FHOH657
FHOH679
FHOH692
FHOH705

site_idAD6
Number of Residues28
Detailsbinding site for residue UPG F 502
ChainResidue
EARG260
FGLU161
FPHE162
FLEU163
FALA164
FGLU165
FLYS220
FASN224
FILE231
FPHE265
FLEU266
FLYS267
FSER269
FPHE272
FGLY273
FCYS276
FPHE277
FPHE338
FLYS339
FARG442
FNAI501
FHOH628
FHOH638
FHOH651
FHOH655
FHOH657
FHOH664
FHOH682

site_idAD7
Number of Residues5
Detailsbinding site for residue DMS F 503
ChainResidue
EASP258
EARG260
FPHE162
FASP171
FASP176

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:22123821
ChainResidueDetails
AGLU161
ELYS220
FGLU161
FLYS220
ALYS220
BGLU161
BLYS220
CGLU161
CLYS220
DGLU161
DLYS220
EGLU161

site_idSWS_FT_FI2
Number of Residues6
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821
ChainResidueDetails
ACYS276
BCYS276
CCYS276
DCYS276
ECYS276
FCYS276

site_idSWS_FT_FI3
Number of Residues30
DetailsBINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
ChainResidueDetails
AGLY11
BCYS276
CGLY11
CASP36
CARG41
CVAL89
CCYS276
DGLY11
DASP36
DARG41
DVAL89
AASP36
DCYS276
EGLY11
EASP36
EARG41
EVAL89
ECYS276
FGLY11
FASP36
FARG41
FVAL89
AARG41
FCYS276
AVAL89
ACYS276
BGLY11
BASP36
BARG41
BVAL89

site_idSWS_FT_FI4
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445
ChainResidueDetails
ASER130
BSER130
CSER130
DSER130
ESER130
FSER130

site_idSWS_FT_FI5
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
ChainResidueDetails
AGLU161
CLYS220
CLYS267
CPHE338
DGLU161
DLYS220
DLYS267
DPHE338
EGLU161
ELYS220
ELYS267
ALYS220
EPHE338
FGLU161
FLYS220
FLYS267
FPHE338
ALYS267
APHE338
BGLU161
BLYS220
BLYS267
BPHE338
CGLU161

site_idSWS_FT_FI6
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4
ChainResidueDetails
AGLU165
BGLU165
CGLU165
DGLU165
EGLU165
FGLU165

site_idSWS_FT_FI7
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH
ChainResidueDetails
AARG260
BARG260
CARG260
DARG260
EARG260
FARG260

site_idSWS_FT_FI8
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
ChainResidueDetails
AARG346
BARG346
CARG346
DARG346
EARG346
FARG346

site_idSWS_FT_FI9
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
ChainResidueDetails
AARG442
BARG442
CARG442
DARG442
EARG442
FARG442

site_idSWS_FT_FI10
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS107
BLYS107
CLYS107
DLYS107
ELYS107
FLYS107

site_idSWS_FT_FI11
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER476
BSER476
CSER476
DSER476
ESER476
FSER476

217705

PDB entries from 2024-03-27

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