6C5A

Human UDP-Glucose Dehydrogenase with UDP- Glc and NADH bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001702	biological_process	gastrulation with mouth forming second
A	0003824	molecular_function	catalytic activity
A	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006024	biological_process	glycosaminoglycan biosynthetic process
A	0006065	biological_process	UDP-glucuronate biosynthetic process
A	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0034214	biological_process	protein hexamerization
A	0042802	molecular_function	identical protein binding
A	0048666	biological_process	neuron development
A	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
A	0051287	molecular_function	NAD binding
A	0070062	cellular_component	extracellular exosome
B	0001702	biological_process	gastrulation with mouth forming second
B	0003824	molecular_function	catalytic activity
B	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005829	cellular_component	cytosol
B	0006024	biological_process	glycosaminoglycan biosynthetic process
B	0006065	biological_process	UDP-glucuronate biosynthetic process
B	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0034214	biological_process	protein hexamerization
B	0042802	molecular_function	identical protein binding
B	0048666	biological_process	neuron development
B	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
B	0051287	molecular_function	NAD binding
B	0070062	cellular_component	extracellular exosome
C	0001702	biological_process	gastrulation with mouth forming second
C	0003824	molecular_function	catalytic activity
C	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005829	cellular_component	cytosol
C	0006024	biological_process	glycosaminoglycan biosynthetic process
C	0006065	biological_process	UDP-glucuronate biosynthetic process
C	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0034214	biological_process	protein hexamerization
C	0042802	molecular_function	identical protein binding
C	0048666	biological_process	neuron development
C	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
C	0051287	molecular_function	NAD binding
C	0070062	cellular_component	extracellular exosome
D	0001702	biological_process	gastrulation with mouth forming second
D	0003824	molecular_function	catalytic activity
D	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0006024	biological_process	glycosaminoglycan biosynthetic process
D	0006065	biological_process	UDP-glucuronate biosynthetic process
D	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0034214	biological_process	protein hexamerization
D	0042802	molecular_function	identical protein binding
D	0048666	biological_process	neuron development
D	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
D	0051287	molecular_function	NAD binding
D	0070062	cellular_component	extracellular exosome
E	0001702	biological_process	gastrulation with mouth forming second
E	0003824	molecular_function	catalytic activity
E	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005829	cellular_component	cytosol
E	0006024	biological_process	glycosaminoglycan biosynthetic process
E	0006065	biological_process	UDP-glucuronate biosynthetic process
E	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0034214	biological_process	protein hexamerization
E	0042802	molecular_function	identical protein binding
E	0048666	biological_process	neuron development
E	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
E	0051287	molecular_function	NAD binding
E	0070062	cellular_component	extracellular exosome
F	0001702	biological_process	gastrulation with mouth forming second
F	0003824	molecular_function	catalytic activity
F	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005829	cellular_component	cytosol
F	0006024	biological_process	glycosaminoglycan biosynthetic process
F	0006065	biological_process	UDP-glucuronate biosynthetic process
F	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0034214	biological_process	protein hexamerization
F	0042802	molecular_function	identical protein binding
F	0048666	biological_process	neuron development
F	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
F	0051287	molecular_function	NAD binding
F	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	binding site for residue NAI A 501

Chain	Residue
A	ILE10
A	VAL89
A	ASN90
A	THR91
A	TYR108
A	SER130
A	THR131
A	GLU161
A	GLU165
A	CYS276
A	LYS279
A	GLY11
A	ARG346
A	UPG502
A	HOH613
A	HOH616
A	HOH639
A	HOH666
A	GLY13
A	TYR14
A	VAL15
A	ASP36
A	VAL37
A	ARG41
A	SER88

---

site_id	AC2
Number of Residues	29
Details	binding site for residue UPG A 502

Chain	Residue
A	GLU161
A	PHE162
A	LEU163
A	ALA164
A	GLU165
A	LYS220
A	ASN224
A	ILE231
A	PHE265
A	LEU266
A	LYS267
A	SER269
A	PHE272
A	GLY273
A	CYS276
A	PHE277
A	PHE338
A	LYS339
A	ARG442
A	NAI501
A	HOH616
A	HOH620
A	HOH625
A	HOH655
A	HOH664
A	HOH673
A	HOH678
A	HOH684
B	ARG260

---

site_id	AC3
Number of Residues	5
Details	binding site for residue DMS A 503

Chain	Residue
A	PHE162
A	ASP171
A	ASP176
B	ASP258
B	ARG260

---

site_id	AC4
Number of Residues	28
Details	binding site for residue NAI B 501

Chain	Residue
B	ILE10
B	GLY11
B	GLY13
B	TYR14
B	VAL15
B	ASP36
B	VAL37
B	ARG41
B	SER88
B	VAL89
B	ASN90
B	THR91
B	TYR108
B	SER130
B	THR131
B	GLU161
B	LEU163
B	GLU165
B	CYS276
B	LYS279
B	ARG346
B	UPG502
B	HOH625
B	HOH629
B	HOH632
B	HOH644
B	HOH687
B	HOH692

---

site_id	AC5
Number of Residues	28
Details	binding site for residue UPG B 502

Chain	Residue
B	LYS267
B	SER269
B	PHE272
B	GLY273
B	CYS276
B	PHE277
B	ASP280
B	PHE338
B	LYS339
B	ARG442
B	NAI501
B	HOH625
B	HOH629
B	HOH638
B	HOH639
B	HOH688
A	ARG260
A	HOH667
B	GLU161
B	PHE162
B	LEU163
B	ALA164
B	GLU165
B	LYS220
B	ASN224
B	ILE231
B	PHE265
B	LEU266

---

site_id	AC6
Number of Residues	6
Details	binding site for residue DMS B 503

Chain	Residue
A	ASP258
A	ARG260
B	PHE162
B	ASP171
B	ASP176
B	HOH622

---

site_id	AC7
Number of Residues	28
Details	binding site for residue NAI C 501

Chain	Residue
C	ILE10
C	GLY11
C	GLY13
C	TYR14
C	VAL15
C	ASP36
C	VAL37
C	ARG41
C	SER88
C	VAL89
C	ASN90
C	THR91
C	TYR108
C	SER130
C	THR131
C	GLU161
C	LEU163
C	GLU165
C	CYS276
C	LYS279
C	ARG346
C	UPG502
C	HOH640
C	HOH642
C	HOH672
C	HOH673
C	HOH695
C	HOH701

---

site_id	AC8
Number of Residues	28
Details	binding site for residue UPG C 502

Chain	Residue
C	GLU161
C	PHE162
C	LEU163
C	ALA164
C	GLU165
C	LYS220
C	ASN224
C	ILE231
C	PHE265
C	LEU266
C	LYS267
C	SER269
C	PHE272
C	GLY273
C	CYS276
C	PHE277
C	PHE338
C	LYS339
C	ARG442
C	NAI501
C	HOH636
C	HOH640
C	HOH642
C	HOH645
C	HOH663
C	HOH683
C	HOH691
D	ARG260

---

site_id	AC9
Number of Residues	5
Details	binding site for residue DMS C 503

Chain	Residue
C	PHE162
C	ASP171
C	HOH692
D	ASP258
D	ARG260

---

site_id	AD1
Number of Residues	25
Details	binding site for residue NAI D 500

Chain	Residue
D	ILE10
D	GLY11
D	GLY13
D	TYR14
D	VAL15
D	ASP36
D	VAL37
D	ASN38
D	ARG41
D	SER88
D	VAL89
D	ASN90
D	THR91
D	TYR108
D	ALA111
D	SER130
D	THR131
D	GLU161
D	GLU165
D	CYS276
D	LYS279
D	ARG346
D	UPG501
D	HOH627
D	HOH630

---

site_id	AD2
Number of Residues	24
Details	binding site for residue UPG D 501

Chain	Residue
C	ARG260
D	GLU161
D	PHE162
D	LEU163
D	ALA164
D	GLU165
D	LYS220
D	ASN224
D	LEU227
D	ILE231
D	PHE265
D	LEU266
D	LYS267
D	SER269
D	PHE272
D	GLY273
D	CYS276
D	PHE277
D	PHE338
D	LYS339
D	ARG442
D	NAI500
D	HOH630
D	HOH654

---

site_id	AD3
Number of Residues	19
Details	binding site for residue NAI E 500

Chain	Residue
E	ILE10
E	GLY11
E	GLY13
E	TYR14
E	VAL15
E	ASP36
E	VAL37
E	ARG41
E	VAL89
E	ASN90
E	THR91
E	TYR108
E	SER130
E	THR131
E	GLU161
E	GLU165
E	CYS276
E	LYS279
E	UPG501

---

site_id	AD4
Number of Residues	21
Details	binding site for residue UPG E 501

Chain	Residue
E	PHE162
E	LEU163
E	GLU165
E	LYS220
E	ASN224
E	ILE231
E	PHE265
E	LEU266
E	LYS267
E	SER269
E	PHE272
E	GLY273
E	CYS276
E	PHE277
E	PHE338
E	LYS339
E	ARG442
E	NAI500
E	HOH613
E	HOH623
F	ARG260

---

site_id	AD5
Number of Residues	30
Details	binding site for residue NAI F 501

Chain	Residue
F	ILE10
F	GLY11
F	GLY13
F	TYR14
F	VAL15
F	ASP36
F	VAL37
F	ARG41
F	ILE75
F	SER88
F	VAL89
F	ASN90
F	THR91
F	TYR108
F	SER130
F	THR131
F	GLU161
F	LEU163
F	GLU165
F	CYS276
F	LYS279
F	ARG346
F	UPG502
F	HOH639
F	HOH643
F	HOH651
F	HOH657
F	HOH679
F	HOH692
F	HOH705

---

site_id	AD6
Number of Residues	28
Details	binding site for residue UPG F 502

Chain	Residue
E	ARG260
F	GLU161
F	PHE162
F	LEU163
F	ALA164
F	GLU165
F	LYS220
F	ASN224
F	ILE231
F	PHE265
F	LEU266
F	LYS267
F	SER269
F	PHE272
F	GLY273
F	CYS276
F	PHE277
F	PHE338
F	LYS339
F	ARG442
F	NAI501
F	HOH628
F	HOH638
F	HOH651
F	HOH655
F	HOH657
F	HOH664
F	HOH682

---

site_id	AD7
Number of Residues	5
Details	binding site for residue DMS F 503

Chain	Residue
E	ASP258
E	ARG260
F	PHE162
F	ASP171
F	ASP176

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	Region: {"description":"Disordered","evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Region: {"description":"Allosteric switch region","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21961565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30457329","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Region: {"description":"Important for formation of active hexamer structure","evidences":[{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	84
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	90
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KHU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---