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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6C58

Human UDP-Glucose Dehydrogenase A225L substitutuion with UDP-xylose bound

Functional Information from GO Data
ChainGOidnamespacecontents
A0001702biological_processgastrulation with mouth forming second
A0003824molecular_functioncatalytic activity
A0003979molecular_functionUDP-glucose 6-dehydrogenase activity
A0005634cellular_componentnucleus
A0005829cellular_componentcytosol
A0006024biological_processglycosaminoglycan biosynthetic process
A0006065biological_processUDP-glucuronate biosynthetic process
A0015012biological_processheparan sulfate proteoglycan biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0034214biological_processprotein hexamerization
A0042802molecular_functionidentical protein binding
A0048666biological_processneuron development
A0050650biological_processchondroitin sulfate proteoglycan biosynthetic process
A0051287molecular_functionNAD binding
A0070062cellular_componentextracellular exosome
B0001702biological_processgastrulation with mouth forming second
B0003824molecular_functioncatalytic activity
B0003979molecular_functionUDP-glucose 6-dehydrogenase activity
B0005634cellular_componentnucleus
B0005829cellular_componentcytosol
B0006024biological_processglycosaminoglycan biosynthetic process
B0006065biological_processUDP-glucuronate biosynthetic process
B0015012biological_processheparan sulfate proteoglycan biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0034214biological_processprotein hexamerization
B0042802molecular_functionidentical protein binding
B0048666biological_processneuron development
B0050650biological_processchondroitin sulfate proteoglycan biosynthetic process
B0051287molecular_functionNAD binding
B0070062cellular_componentextracellular exosome
C0001702biological_processgastrulation with mouth forming second
C0003824molecular_functioncatalytic activity
C0003979molecular_functionUDP-glucose 6-dehydrogenase activity
C0005634cellular_componentnucleus
C0005829cellular_componentcytosol
C0006024biological_processglycosaminoglycan biosynthetic process
C0006065biological_processUDP-glucuronate biosynthetic process
C0015012biological_processheparan sulfate proteoglycan biosynthetic process
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0034214biological_processprotein hexamerization
C0042802molecular_functionidentical protein binding
C0048666biological_processneuron development
C0050650biological_processchondroitin sulfate proteoglycan biosynthetic process
C0051287molecular_functionNAD binding
C0070062cellular_componentextracellular exosome
D0001702biological_processgastrulation with mouth forming second
D0003824molecular_functioncatalytic activity
D0003979molecular_functionUDP-glucose 6-dehydrogenase activity
D0005634cellular_componentnucleus
D0005829cellular_componentcytosol
D0006024biological_processglycosaminoglycan biosynthetic process
D0006065biological_processUDP-glucuronate biosynthetic process
D0015012biological_processheparan sulfate proteoglycan biosynthetic process
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0034214biological_processprotein hexamerization
D0042802molecular_functionidentical protein binding
D0048666biological_processneuron development
D0050650biological_processchondroitin sulfate proteoglycan biosynthetic process
D0051287molecular_functionNAD binding
D0070062cellular_componentextracellular exosome
E0001702biological_processgastrulation with mouth forming second
E0003824molecular_functioncatalytic activity
E0003979molecular_functionUDP-glucose 6-dehydrogenase activity
E0005634cellular_componentnucleus
E0005829cellular_componentcytosol
E0006024biological_processglycosaminoglycan biosynthetic process
E0006065biological_processUDP-glucuronate biosynthetic process
E0015012biological_processheparan sulfate proteoglycan biosynthetic process
E0016491molecular_functionoxidoreductase activity
E0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E0034214biological_processprotein hexamerization
E0042802molecular_functionidentical protein binding
E0048666biological_processneuron development
E0050650biological_processchondroitin sulfate proteoglycan biosynthetic process
E0051287molecular_functionNAD binding
E0070062cellular_componentextracellular exosome
F0001702biological_processgastrulation with mouth forming second
F0003824molecular_functioncatalytic activity
F0003979molecular_functionUDP-glucose 6-dehydrogenase activity
F0005634cellular_componentnucleus
F0005829cellular_componentcytosol
F0006024biological_processglycosaminoglycan biosynthetic process
F0006065biological_processUDP-glucuronate biosynthetic process
F0015012biological_processheparan sulfate proteoglycan biosynthetic process
F0016491molecular_functionoxidoreductase activity
F0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F0034214biological_processprotein hexamerization
F0042802molecular_functionidentical protein binding
F0048666biological_processneuron development
F0050650biological_processchondroitin sulfate proteoglycan biosynthetic process
F0051287molecular_functionNAD binding
F0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues22
Detailsbinding site for residue UDX A 501
ChainResidue
AGLY11
ATHR91
ASER130
ATHR131
ASER275
ALYS279
AARG346
AHOH605
AHOH633
AHOH671
AHOH682
AGLY13
AHOH689
AHOH694
AHOH724
ATYR14
AVAL15
AASP36
AVAL37
AARG41
AVAL89
AASN90
site_idAC2
Number of Residues26
Detailsbinding site for residue UDX A 502
ChainResidue
ATHR131
AGLU161
APHE162
ALEU163
AALA164
AGLU165
ALYS220
AILE231
APHE265
ALEU266
ALYS267
ASER269
APHE272
AGLY273
ACYS276
APHE277
APHE338
ALYS339
AARG442
AHOH618
AHOH619
AHOH647
AHOH683
AHOH720
AHOH762
BARG260
site_idAC3
Number of Residues20
Detailsbinding site for residue UDX B 501
ChainResidue
BGLY11
BGLY13
BTYR14
BVAL15
BASP36
BVAL37
BARG41
BVAL89
BASN90
BTHR91
BSER130
BTHR131
BSER275
BLYS279
BARG346
BHOH648
BHOH649
BHOH654
BHOH665
BHOH675
site_idAC4
Number of Residues24
Detailsbinding site for residue UDX B 502
ChainResidue
AARG260
BGLU161
BPHE162
BLEU163
BALA164
BGLU165
BLYS220
BILE231
BPHE265
BLEU266
BLYS267
BSER269
BPHE272
BGLY273
BCYS276
BPHE277
BPHE338
BLYS339
BARG442
BHOH624
BHOH683
BHOH704
BHOH712
BHOH717
site_idAC5
Number of Residues22
Detailsbinding site for residue UDX C 500
ChainResidue
CVAL89
CASN90
CTHR91
CSER130
CTHR131
CVAL132
CSER275
CLYS279
CARG346
CHOH665
CHOH679
CHOH688
CHOH693
CHOH705
CHOH711
CGLY11
CGLY13
CTYR14
CVAL15
CASP36
CVAL37
CARG41
site_idAC6
Number of Residues24
Detailsbinding site for residue UDX C 501
ChainResidue
CGLU161
CPHE162
CLEU163
CALA164
CGLU165
CLYS220
CILE231
CPHE265
CLEU266
CLYS267
CSER269
CPHE272
CGLY273
CCYS276
CPHE277
CPHE338
CLYS339
CARG442
CHOH606
CHOH655
CHOH675
CHOH725
DARG260
DHOH670
site_idAC7
Number of Residues24
Detailsbinding site for residue UDX D 501
ChainResidue
CARG260
DGLU161
DPHE162
DLEU163
DALA164
DGLU165
DLYS220
DILE231
DPHE265
DLEU266
DLYS267
DSER269
DPHE272
DGLY273
DCYS276
DPHE277
DPHE338
DLYS339
DARG442
DHOH607
DHOH618
DHOH620
DHOH621
DHOH662
site_idAC8
Number of Residues2
Detailsbinding site for residue CL D 502
ChainResidue
DMET358
DGLN390
site_idAC9
Number of Residues25
Detailsbinding site for residue UDX E 501
ChainResidue
ETHR131
EGLU161
EPHE162
ELEU163
EALA164
EGLU165
ELYS220
EILE231
EPHE265
ELEU266
ELYS267
ESER269
EPHE272
EGLY273
ECYS276
EPHE277
EPHE338
ELYS339
EARG442
EHOH628
EHOH651
EHOH667
EHOH686
FARG260
FHOH669
site_idAD1
Number of Residues18
Detailsbinding site for residue UDX F 500
ChainResidue
FGLY11
FGLY13
FTYR14
FVAL15
FASP36
FVAL37
FARG41
FVAL89
FASN90
FTHR91
FTYR108
FSER130
FTHR131
FSER275
FLYS279
FARG346
FHOH655
FHOH658
site_idAD2
Number of Residues22
Detailsbinding site for residue UDX F 501
ChainResidue
EARG260
FGLU161
FPHE162
FLEU163
FALA164
FGLU165
FLYS220
FILE231
FPHE265
FLEU266
FLYS267
FSER269
FPHE272
FGLY273
FCYS276
FPHE277
FPHE338
FLYS339
FARG442
FHOH603
FHOH605
FHOH643
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues88
DetailsRegion: {"description":"Disordered","evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues36
DetailsRegion: {"description":"Allosteric switch region","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21961565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30457329","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues24
DetailsRegion: {"description":"Important for formation of active hexamer structure","evidences":[{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsActive site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues76
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues90
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TJH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KHU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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