6C4K
Full length hUGDH with A104L substitution in the absence of ligand
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001702 | biological_process | gastrulation with mouth forming second |
A | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
A | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
A | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
A | 0034214 | biological_process | protein hexamerization |
A | 0042802 | molecular_function | identical protein binding |
A | 0048666 | biological_process | neuron development |
A | 0051287 | molecular_function | NAD binding |
A | 0070062 | cellular_component | extracellular exosome |
B | 0001702 | biological_process | gastrulation with mouth forming second |
B | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
B | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
B | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
B | 0034214 | biological_process | protein hexamerization |
B | 0042802 | molecular_function | identical protein binding |
B | 0048666 | biological_process | neuron development |
B | 0051287 | molecular_function | NAD binding |
B | 0070062 | cellular_component | extracellular exosome |
C | 0001702 | biological_process | gastrulation with mouth forming second |
C | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
C | 0005634 | cellular_component | nucleus |
C | 0005654 | cellular_component | nucleoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
C | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
C | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
C | 0034214 | biological_process | protein hexamerization |
C | 0042802 | molecular_function | identical protein binding |
C | 0048666 | biological_process | neuron development |
C | 0051287 | molecular_function | NAD binding |
C | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue PO4 A 501 |
Chain | Residue |
A | ILE231 |
A | PHE272 |
A | GLY273 |
A | PHE277 |
A | PHE338 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue NA B 501 |
Chain | Residue |
B | MET98 |
C | ARG312 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue PO4 B 502 |
Chain | Residue |
B | PHE277 |
B | PHE338 |
B | PHE272 |
B | GLY273 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue PO4 C 501 |
Chain | Residue |
C | ILE231 |
C | PHE272 |
C | GLY273 |
C | PHE277 |
C | PHE338 |
C | LYS339 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:22123821 |
Chain | Residue | Details |
A | GLU161 | |
A | LYS220 | |
B | GLU161 | |
B | LYS220 | |
C | GLU161 | |
C | LYS220 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821 |
Chain | Residue | Details |
A | CYS276 | |
B | CYS276 | |
C | CYS276 |
site_id | SWS_FT_FI3 |
Number of Residues | 15 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK |
Chain | Residue | Details |
A | GLY11 | |
B | CYS276 | |
C | GLY11 | |
C | ASP36 | |
C | ARG41 | |
C | VAL89 | |
C | CYS276 | |
A | ASP36 | |
A | ARG41 | |
A | VAL89 | |
A | CYS276 | |
B | GLY11 | |
B | ASP36 | |
B | ARG41 | |
B | VAL89 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445 |
Chain | Residue | Details |
A | SER130 | |
B | SER130 | |
C | SER130 |
site_id | SWS_FT_FI5 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF |
Chain | Residue | Details |
A | GLU161 | |
C | LYS220 | |
C | LYS267 | |
C | PHE338 | |
A | LYS220 | |
A | LYS267 | |
A | PHE338 | |
B | GLU161 | |
B | LYS220 | |
B | LYS267 | |
B | PHE338 | |
C | GLU161 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4 |
Chain | Residue | Details |
A | GLU165 | |
B | GLU165 | |
C | GLU165 |
site_id | SWS_FT_FI7 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH |
Chain | Residue | Details |
A | ARG260 | |
B | ARG260 | |
C | ARG260 |
site_id | SWS_FT_FI8 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK |
Chain | Residue | Details |
A | ARG346 | |
B | ARG346 | |
C | ARG346 |
site_id | SWS_FT_FI9 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF |
Chain | Residue | Details |
A | ARG442 | |
B | ARG442 | |
C | ARG442 |
site_id | SWS_FT_FI10 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS107 | |
B | LYS107 | |
C | LYS107 |
site_id | SWS_FT_FI11 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER476 | |
B | SER476 | |
C | SER476 |