6C1P

HypoPP mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001518	cellular_component	voltage-gated sodium channel complex
A	0005216	molecular_function	monoatomic ion channel activity
A	0005248	molecular_function	voltage-gated sodium channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
B	0001518	cellular_component	voltage-gated sodium channel complex
B	0005216	molecular_function	monoatomic ion channel activity
B	0005248	molecular_function	voltage-gated sodium channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
C	0001518	cellular_component	voltage-gated sodium channel complex
C	0005216	molecular_function	monoatomic ion channel activity
C	0005248	molecular_function	voltage-gated sodium channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
D	0001518	cellular_component	voltage-gated sodium channel complex
D	0005216	molecular_function	monoatomic ion channel activity
D	0005248	molecular_function	voltage-gated sodium channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PX4 A 1302

Chain	Residue
A	GLY1030
A	SER1034
A	THR1036
C	THR1162
C	LEU1163
C	PX41303

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PX4 A 1303

Chain	Residue
A	ALA1194
A	PHE1152
A	TYR1191
A	TYR1193

---

site_id	AC3
Number of Residues	13
Details	binding site for residue PX4 A 1304

Chain	Residue
A	MET1137
A	THR1138
A	GLU1165
A	PHE1167
A	TYR1168
A	PHE1171
A	MET1209
B	PX42003
C	MET1188
C	PRO1192
C	TRP1195
C	ILE1199
C	PHE1203

---

site_id	AC4
Number of Residues	11
Details	binding site for residue PX4 B 2001

Chain	Residue
A	TYR1193
A	TRP1195
A	PHE1203
B	MET1137
B	THR1138
B	PHE1141
B	GLY1164
B	PHE1167
B	TYR1168
B	MET1209
B	PX42006

---

site_id	AC5
Number of Residues	1
Details	binding site for residue PX4 B 2002

Chain	Residue
B	GLN1115

---

site_id	AC6
Number of Residues	6
Details	binding site for residue PX4 B 2003

Chain	Residue
A	THR1162
A	PX41304
B	GLY1030
B	SER1034
B	THR1036
B	PX42004

---

site_id	AC7
Number of Residues	1
Details	binding site for residue PX4 B 2004

Chain	Residue
B	PX42003

---

site_id	AC8
Number of Residues	5
Details	binding site for residue PX4 B 2005

Chain	Residue
B	LEU1151
B	TYR1191
B	TYR1193
D	PHE1095
D	ILE1097

---

site_id	AC9
Number of Residues	8
Details	binding site for residue PX4 B 2006

Chain	Residue
B	TYR1142
B	THR1162
B	LEU1163
B	PX42001
D	ILE1027
D	GLY1030
D	LEU1031
D	PX41305

---

site_id	AD1
Number of Residues	2
Details	binding site for residue 1N7 C 1301

Chain	Residue
C	ARG1155
C	TYR1191

---

site_id	AD2
Number of Residues	2
Details	binding site for residue PX4 C 1302

Chain	Residue
C	SER1034
D	PX41303

---

site_id	AD3
Number of Residues	10
Details	binding site for residue PX4 C 1303

Chain	Residue
A	PX41302
C	ILE1134
C	MET1137
C	THR1138
C	PHE1141
C	THR1162
C	GLY1164
C	GLU1165
C	PHE1167
D	TRP1195

---

site_id	AD4
Number of Residues	12
Details	binding site for residue PX4 D 1302

Chain	Residue
B	MET1188
B	TRP1195
B	PHE1203
D	MET1137
D	THR1138
D	THR1162
D	GLY1164
D	GLU1165
D	PHE1167
D	TYR1168
D	PHE1171
D	PX41303

---

site_id	AD5
Number of Residues	11
Details	binding site for residue PX4 D 1303

Chain	Residue
C	VAL1023
C	ILE1027
C	GLY1030
C	LEU1031
C	SER1034
C	LEU1109
C	PX41302
D	TYR1142
D	THR1162
D	GLY1164
D	PX41302

---

site_id	AD6
Number of Residues	5
Details	binding site for residue PX4 D 1304

Chain	Residue
D	ARG1155
D	TYR1191
D	PRO1192
D	TYR1193
D	ALA1194

---

site_id	AD7
Number of Residues	2
Details	binding site for residue PX4 D 1305

Chain	Residue
B	PX42006
D	THR1036

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