6BWW
Crystal structure of an acetate and Cymal-5 bound cytochrome P450 2B4 F429H mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008392 | molecular_function | arachidonic acid epoxygenase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0016712 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| A | 0019373 | biological_process | epoxygenase P450 pathway |
| A | 0020037 | molecular_function | heme binding |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070330 | molecular_function | aromatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | ARG98 |
| A | THR303 |
| A | THR306 |
| A | GLN357 |
| A | ILE363 |
| A | VAL367 |
| A | HIS369 |
| A | LEU392 |
| A | PRO428 |
| A | HIS429 |
| A | SER430 |
| A | VAL113 |
| A | ARG434 |
| A | CYS436 |
| A | LEU437 |
| A | GLY438 |
| A | ALA442 |
| A | ACT504 |
| A | HOH716 |
| A | ILE114 |
| A | TRP121 |
| A | ARG125 |
| A | ILE179 |
| A | ALA298 |
| A | GLY299 |
| A | THR302 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue CM5 A 502 |
| Chain | Residue |
| A | LYS186 |
| A | PHE188 |
| A | LEU198 |
| A | PHE244 |
| A | LYS251 |
| A | PHE296 |
| A | ACT506 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue CM5 A 503 |
| Chain | Residue |
| A | ILE101 |
| A | ILE114 |
| A | PHE115 |
| A | PHE297 |
| A | PHE365 |
| A | GLY366 |
| A | PRO368 |
| A | GLY476 |
| A | VAL477 |
| A | HOH617 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 504 |
| Chain | Residue |
| A | ALA298 |
| A | THR302 |
| A | ILE363 |
| A | HEM501 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 505 |
| Chain | Residue |
| A | ILE468 |
| A | ASP469 |
| A | PRO482 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue ACT A 506 |
| Chain | Residue |
| A | LYS186 |
| A | PHE244 |
| A | SER248 |
| A | LYS251 |
| A | HIS252 |
| A | CM5502 |
| A | GOL514 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 507 |
| Chain | Residue |
| A | SER96 |
| A | ASN117 |
| A | GLY118 |
| A | THR372 |
| A | ARG434 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 508 |
| Chain | Residue |
| A | PHE135 |
| A | MET137 |
| A | ARG145 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 509 |
| Chain | Residue |
| A | PHE244 |
| A | GLN247 |
| A | SER248 |
| A | LYS251 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 510 |
| Chain | Residue |
| A | ARG125 |
| A | LEU129 |
| A | ARG133 |
| A | HOH602 |
| A | HOH607 |
| A | HOH789 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 511 |
| Chain | Residue |
| A | ARG323 |
| A | HOH675 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 512 |
| Chain | Residue |
| A | PHE426 |
| A | MET427 |
| A | PRO428 |
| A | HIS429 |
| A | SER430 |
| A | ILE435 |
| A | GLU439 |
| A | HOH612 |
| A | HOH631 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 513 |
| Chain | Residue |
| A | LYS316 |
| A | TYR317 |
| A | PRO465 |
| A | GLU466 |
| A | HOH619 |
| A | HOH704 |
| A | HOH878 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 514 |
| Chain | Residue |
| A | PHE184 |
| A | GLY185 |
| A | LYS251 |
| A | HIS252 |
| A | ACT506 |
| A | HOH741 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 515 |
| Chain | Residue |
| A | ARG197 |
| A | GLU240 |
| A | THR243 |
| A | PHE244 |
| A | GLN247 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 516 |
| Chain | Residue |
| A | ASP82 |
| A | ARG85 |
| A | GLU86 |
| A | ASP90 |
| A | HOH626 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 517 |
| Chain | Residue |
| A | HIS354 |
| A | LYS421 |
| A | ARG422 |
| A | ASN423 |
| A | PHE426 |
| A | HOH601 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | CYS436 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:P00176 |
| Chain | Residue | Details |
| A | SER128 |
