6BWI

3.7 angstrom cryoEM structure of full length human TRPM4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	492
Details	TRANSMEM: Helical => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581

Chain	Residue	Details
A	PHE783-VAL803
B	LEU887-PHE910
B	PHE931-LEU951
B	VAL1020-ILE1040
C	PHE783-VAL803
C	LEU815-GLY835
C	TRP864-THR884
C	LEU887-PHE910
C	PHE931-LEU951
C	VAL1020-ILE1040
D	PHE783-VAL803
A	LEU815-GLY835
D	LEU815-GLY835
D	TRP864-THR884
D	LEU887-PHE910
D	PHE931-LEU951
D	VAL1020-ILE1040
A	TRP864-THR884
A	LEU887-PHE910
A	PHE931-LEU951
A	VAL1020-ILE1040
B	PHE783-VAL803
B	LEU815-GLY835
B	TRP864-THR884

---

site_id	SWS_FT_FI2
Number of Residues	224
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581

Chain	Residue	Details
A	ASP804-GLU814
C	PRO885-GLY886
C	LEU952-LEU963
C	VAL985-LEU1019
D	ASP804-GLU814
D	PRO885-GLY886
D	LEU952-LEU963
D	VAL985-LEU1019
A	PRO885-GLY886
A	LEU952-LEU963
A	VAL985-LEU1019
B	ASP804-GLU814
B	PRO885-GLY886
B	LEU952-LEU963
B	VAL985-LEU1019
C	ASP804-GLU814

---

site_id	SWS_FT_FI3
Number of Residues	184
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581

Chain	Residue	Details
A	GLY836-SER863
A	THR911-VAL930
B	GLY836-SER863
B	THR911-VAL930
C	GLY836-SER863
C	THR911-VAL930
D	GLY836-SER863
D	THR911-VAL930

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	INTRAMEM: Pore-forming => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581

Chain	Residue	Details
A	ARG964-ASP984
B	ARG964-ASP984
C	ARG964-ASP984
D	ARG964-ASP984

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:38750366, ECO:0007744|PDB:9B8W, ECO:0007744|PDB:9B8Y

Chain	Residue	Details
A	ASP395
A	GLU396
B	ASP395
B	GLU396
C	ASP395
C	GLU396
D	ASP395
D	GLU396

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: in other chain => ECO:0000250|UniProtKB:Q7TN37

Chain	Residue	Details
A	ARG421
A	GLY448
B	ARG421
B	GLY448
C	ARG421
C	GLY448
D	ARG421
D	GLY448

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:29217581, ECO:0007744|PDB:6BQV

Chain	Residue	Details
A	GLU828
B	GLU828
C	GLU828
D	GLU828

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:29217581, ECO:0000269|PubMed:38750366, ECO:0007744|PDB:6BQV, ECO:0007744|PDB:9B92

Chain	Residue	Details
A	GLN831
A	ASN865
B	GLN831
B	ASN865
C	GLN831
C	ASN865
D	GLN831
D	ASN865

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:38750366, ECO:0000305|PubMed:29217581, ECO:0007744|PDB:6BQV, ECO:0007744|PDB:9B92

Chain	Residue	Details
A	ASP868
B	ASP868
C	ASP868
D	ASP868

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000305|PubMed:15590641

Chain	Residue	Details
A	SER1145
A	SER1152
B	SER1145
B	SER1152
C	SER1145
C	SER1152
D	SER1145
D	SER1152

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29217581

Chain	Residue	Details
A	ASN992
B	ASN992
C	ASN992
D	ASN992

---