6BV4

Crystal structure of porcine aminopeptidase-N with Methionine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0001618	molecular_function	virus receptor activity
A	0004177	molecular_function	aminopeptidase activity
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016285	molecular_function	obsolete cytosol alanyl aminopeptidase activity
A	0030154	biological_process	cell differentiation
A	0042277	molecular_function	peptide binding
A	0043171	biological_process	peptide catabolic process
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIAHELAHQW

Chain	Residue	Details
A	VAL380-TRP389

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
A	GLU384

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P15144

Chain	Residue	Details
A	GLY347

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:22876187, ECO:0007744|PDB:4F5C

Chain	Residue	Details
A	HIS383
A	HIS387
A	GLU406

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P15144

Chain	Residue	Details
A	TYR472

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000255

Chain	Residue	Details
A	TYR171

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site_id	SWS_FT_FI6
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22876187, ECO:0007744|PDB:4F5C

Chain	Residue	Details
A	ASN82
A	ASN736
A	ASN124
A	ASN229
A	ASN237
A	ASN314
A	ASN328
A	ASN506
A	ASN622
A	ASN646

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site_id	SWS_FT_FI7
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN258
A	ASN286
A	ASN556
A	ASN569

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