6BUV
Structure of Mycobacterium tuberculosis NadD in complex with inhibitor [(1~{R},2~{R},5~{S})-5-methyl-2-propan-2-yl-cyclohexyl] 2-[3-methyl-2-(phenoxymethyl)benzimidazol-1-yl]ethanoate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000309 | molecular_function | nicotinamide-nucleotide adenylyltransferase activity |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004515 | molecular_function | nicotinate-nucleotide adenylyltransferase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0009435 | biological_process | NAD+ biosynthetic process |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0034355 | biological_process | NAD+ biosynthetic process via the salvage pathway |
| A | 0070566 | molecular_function | adenylyltransferase activity |
| B | 0000309 | molecular_function | nicotinamide-nucleotide adenylyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004515 | molecular_function | nicotinate-nucleotide adenylyltransferase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0009435 | biological_process | NAD+ biosynthetic process |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0034355 | biological_process | NAD+ biosynthetic process via the salvage pathway |
| B | 0070566 | molecular_function | adenylyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 301 |
| Chain | Residue |
| A | ARG128 |
| A | ASP154 |
| A | LEU156 |
| A | THR157 |
| A | HOH426 |
| B | SER116 |
| B | TRP117 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 302 |
| Chain | Residue |
| A | VAL73 |
| A | ARG196 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 303 |
| Chain | Residue |
| A | HIS97 |
| A | PRO98 |
| A | ASP99 |
| A | SER100 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 304 |
| Chain | Residue |
| A | TYR85 |
| A | GLY119 |
| A | HOH483 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue E9A B 301 |
| Chain | Residue |
| A | LEU158 |
| A | GLU160 |
| B | ALA108 |
| B | ASP109 |
| B | ALA112 |
| B | SER113 |
| B | SER116 |
| B | ILE144 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 302 |
| Chain | Residue |
| B | VAL73 |
| B | ARG196 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue CL B 303 |
| Chain | Residue |
| B | HIS17 |
| B | HIS20 |
| B | ARG134 |
| B | SER167 |
| B | SER168 |
| B | HOH482 |
