6BUQ
Crystal structures of cyanuric acid hydrolase from Moorella thermoacetica complexed with barbituric acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| A | 0018753 | molecular_function | cyanuric acid amidohydrolase activity |
| A | 0019381 | biological_process | atrazine catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| B | 0018753 | molecular_function | cyanuric acid amidohydrolase activity |
| B | 0019381 | biological_process | atrazine catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| C | 0018753 | molecular_function | cyanuric acid amidohydrolase activity |
| C | 0019381 | biological_process | atrazine catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| D | 0018753 | molecular_function | cyanuric acid amidohydrolase activity |
| D | 0019381 | biological_process | atrazine catabolic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue MLI A 401 |
| Chain | Residue |
| A | GLY45 |
| A | GLY348 |
| A | HOH551 |
| A | ARG52 |
| A | SER83 |
| A | GLY84 |
| A | LYS161 |
| A | SER231 |
| A | ALA232 |
| A | ARG328 |
| A | SER347 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 402 |
| Chain | Residue |
| A | GLU301 |
| A | ALA350 |
| A | GLN353 |
| A | GLY354 |
| A | PRO355 |
| A | GLY358 |
| A | HOH691 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 403 |
| Chain | Residue |
| A | PHE54 |
| A | GLN57 |
| B | GLN57 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PDO A 404 |
| Chain | Residue |
| A | GLY53 |
| A | THR56 |
| A | GLN57 |
| A | HOH571 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue PDO A 405 |
| Chain | Residue |
| A | VAL47 |
| A | ASP184 |
| A | THR185 |
| A | TYR186 |
| A | HOH607 |
| D | LEU316 |
| D | ASP318 |
| D | SER319 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue CL A 406 |
| Chain | Residue |
| A | ASP49 |
| A | PHE50 |
| A | ARG52 |
| A | GLY53 |
| A | VAL234 |
| A | GLU235 |
| A | HOH726 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue BR8 B 401 |
| Chain | Residue |
| B | GLY45 |
| B | ARG52 |
| B | SER83 |
| B | GLY84 |
| B | ARG193 |
| B | SER231 |
| B | ALA232 |
| B | ARG328 |
| B | SER347 |
| B | GLY348 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 402 |
| Chain | Residue |
| B | GLU301 |
| B | ALA350 |
| B | GLN353 |
| B | GLY354 |
| B | PRO355 |
| B | GLY358 |
| B | HOH570 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue PDO B 403 |
| Chain | Residue |
| B | TRP221 |
| B | GLU301 |
| B | ALA350 |
| B | GLU351 |
| B | ASP356 |
| B | HOH517 |
| B | HOH534 |
| B | HOH570 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue PDO B 404 |
| Chain | Residue |
| B | GLU5 |
| B | VAL6 |
| B | LEU254 |
| B | ARG366 |
| B | HOH522 |
| B | HOH647 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 405 |
| Chain | Residue |
| A | GLY340 |
| B | LYS28 |
| C | ARG309 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for residue BR8 C 401 |
| Chain | Residue |
| C | GLY45 |
| C | ARG52 |
| C | SER83 |
| C | GLY84 |
| C | LYS161 |
| C | MET189 |
| C | ARG193 |
| C | SER231 |
| C | ALA232 |
| C | ARG328 |
| C | SER347 |
| C | GLY348 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 402 |
| Chain | Residue |
| C | GLU301 |
| C | ALA350 |
| C | GLN353 |
| C | GLY354 |
| C | PRO355 |
| C | GLY358 |
| C | HOH564 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue PDO C 403 |
| Chain | Residue |
| C | ARG8 |
| C | PRO10 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue PDO C 404 |
| Chain | Residue |
| C | HOH621 |
| C | HOH624 |
| C | GLU5 |
| C | VAL6 |
| C | LEU254 |
| C | HOH618 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue PDO C 405 |
| Chain | Residue |
| A | GLU87 |
| A | GLY88 |
| A | HOH524 |
| C | ILE321 |
| C | SER326 |
| C | ALA329 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue PDO C 406 |
| Chain | Residue |
| C | TRP221 |
| C | GLU301 |
| C | ALA302 |
| C | GLU351 |
| C | ASP356 |
| C | HOH548 |
| C | HOH564 |
| site_id | AD9 |
| Number of Residues | 11 |
| Details | binding site for residue BR8 D 401 |
| Chain | Residue |
| D | GLY45 |
| D | ARG52 |
| D | SER83 |
| D | GLY84 |
| D | MET189 |
| D | ARG193 |
| D | SER231 |
| D | ALA232 |
| D | ARG328 |
| D | SER347 |
| D | GLY348 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue CA D 402 |
| Chain | Residue |
| D | GLU301 |
| D | ALA350 |
| D | GLN353 |
| D | GLY354 |
| D | PRO355 |
| D | GLY358 |
| D | HOH557 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue PDO D 403 |
| Chain | Residue |
| B | GLU87 |
| B | GLY88 |
| B | HOH596 |
| D | ILE321 |
| D | SER326 |
| D | ALA329 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue PEG D 404 |
| Chain | Residue |
| D | TRP221 |
| D | GLU301 |
| D | ALA302 |
| D | HIS323 |
| D | GLU351 |
| D | ASP356 |
| D | HOH557 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 412 |
| Details | Region: {"description":"RU A","evidences":[{"source":"HAMAP-Rule","id":"MF_01989","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 548 |
| Details | Region: {"description":"RU B","evidences":[{"source":"HAMAP-Rule","id":"MF_01989","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01989","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01989","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01989","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for substrate specificity","evidences":[{"source":"HAMAP-Rule","id":"MF_01989","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
