6BPZ
Structure of the mechanically activated ion channel Piezo1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YQCVAAH |
| Chain | Residue | Details |
| A | TYR1680-HIS1686 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | Transmembrane: {"description":"Helical; Name=25","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 90 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=26","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 96 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=27","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=28","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=31","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=34","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=35","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 45 |
| Details | Transmembrane: {"description":"Helical; Name=36","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=37","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 132 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 39 |
| Details | Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
