6BPZ

Structure of the mechanically activated ion channel Piezo1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YQCVAAH

Chain	Residue	Details
A	TYR1680-HIS1686

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	900
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	VAL1155-THR1175
A	ALA2019-LEU2039
A	ALA2048-VAL2068
A	ALA2077-ILE2097
A	THR2145-ILE2165
A	GLY2193-ILE2213
A	LEU2458-GLY2478
B	VAL1155-THR1175
B	ILE1179-LEU1199
B	LEU1207-LEU1227
B	CYS1232-VAL1252
A	ILE1179-LEU1199
B	LEU1272-LEU1292
B	ALA1678-ASN1698
B	MET1700-LEU1720
B	ILE1734-TRP1754
B	ALA1978-PHE1998
B	ALA2019-LEU2039
B	ALA2048-VAL2068
B	ALA2077-ILE2097
B	THR2145-ILE2165
B	GLY2193-ILE2213
A	LEU1207-LEU1227
B	LEU2458-GLY2478
C	VAL1155-THR1175
C	ILE1179-LEU1199
C	LEU1207-LEU1227
C	CYS1232-VAL1252
C	LEU1272-LEU1292
C	ALA1678-ASN1698
C	MET1700-LEU1720
C	ILE1734-TRP1754
C	ALA1978-PHE1998
A	CYS1232-VAL1252
C	ALA2019-LEU2039
C	ALA2048-VAL2068
C	ALA2077-ILE2097
C	THR2145-ILE2165
C	GLY2193-ILE2213
C	LEU2458-GLY2478
A	LEU1272-LEU1292
A	ALA1678-ASN1698
A	MET1700-LEU1720
A	ILE1734-TRP1754
A	ALA1978-PHE1998

---

site_id	SWS_FT_FI2
Number of Residues	729
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:26390154

Chain	Residue	Details
A	ARG2214-SER2457
B	ARG2214-SER2457
C	ARG2214-SER2457

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19144319

Chain	Residue	Details
A	SER1385
B	SER1385
C	SER1385

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q92508

Chain	Residue	Details
A	SER1390
B	SER1390
C	SER1390

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	UNK1611
A	UNK1615
B	UNK1611
B	UNK1615
C	UNK1611
C	UNK1615

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	UNK1630
B	UNK1630
C	UNK1630

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