6BOO
Crystal structure of 2-methylcitrate synthase from Aspergillus fumigatus with oxaloacetate and coenzyme-A.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019629 | biological_process | propionate catabolic process, 2-methylcitrate cycle |
| A | 0036440 | molecular_function | citrate synthase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| A | 0050440 | molecular_function | 2-methylcitrate synthase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019629 | biological_process | propionate catabolic process, 2-methylcitrate cycle |
| B | 0036440 | molecular_function | citrate synthase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| B | 0050440 | molecular_function | 2-methylcitrate synthase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019629 | biological_process | propionate catabolic process, 2-methylcitrate cycle |
| C | 0036440 | molecular_function | citrate synthase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| C | 0050440 | molecular_function | 2-methylcitrate synthase activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0016740 | molecular_function | transferase activity |
| D | 0019629 | biological_process | propionate catabolic process, 2-methylcitrate cycle |
| D | 0036440 | molecular_function | citrate synthase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| D | 0050440 | molecular_function | 2-methylcitrate synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue OAA B 501 |
| Chain | Residue |
| B | HIS269 |
| B | HOH603 |
| B | HOH604 |
| B | HOH618 |
| C | ARG454 |
| B | ASN273 |
| B | HIS305 |
| B | HIS351 |
| B | ARG360 |
| B | ASP408 |
| B | PHE430 |
| B | ARG434 |
| B | COA503 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue OAA B 502 |
| Chain | Residue |
| A | GLU63 |
| D | ASP58 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | binding site for residue COA B 503 |
| Chain | Residue |
| B | ARG74 |
| B | LEU304 |
| B | HIS305 |
| B | ALA308 |
| B | LEU340 |
| B | VAL345 |
| B | VAL346 |
| B | PRO347 |
| B | GLY348 |
| B | TYR349 |
| B | GLY350 |
| B | HIS351 |
| B | GLY352 |
| B | LEU394 |
| B | LYS399 |
| B | THR400 |
| B | LYS401 |
| B | ASN406 |
| B | ASP408 |
| B | OAA501 |
| C | LYS192 |
| C | HOH641 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue OAA A 501 |
| Chain | Residue |
| A | HIS269 |
| A | ASN273 |
| A | HIS305 |
| A | HIS351 |
| A | ARG360 |
| A | ASP408 |
| A | PHE430 |
| A | ARG434 |
| A | COA502 |
| A | HOH614 |
| A | HOH617 |
| D | ARG454 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | binding site for residue COA A 502 |
| Chain | Residue |
| A | ARG74 |
| A | LEU304 |
| A | ALA308 |
| A | LEU340 |
| A | VAL345 |
| A | VAL346 |
| A | GLY348 |
| A | TYR349 |
| A | GLY350 |
| A | HIS351 |
| A | GLY352 |
| A | LEU394 |
| A | LYS399 |
| A | THR400 |
| A | LYS401 |
| A | ASN406 |
| A | ASP408 |
| A | OAA501 |
| A | HOH616 |
| D | LYS192 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue OAA C 501 |
| Chain | Residue |
| C | ARG74 |
| C | LYS401 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue OAA D 501 |
| Chain | Residue |
| D | ARG74 |
| D | HIS351 |
| D | GLY352 |
| D | LYS401 |
Functional Information from PROSITE/UniProt
| site_id | PS00480 |
| Number of Residues | 13 |
| Details | CITRATE_SYNTHASE Citrate synthase signature. GYGHgVl.RkpDPR |
| Chain | Residue | Details |
| B | GLY348-ARG360 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"O34002","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"31141475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BOO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"31141475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BOO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"31141475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BOO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"31141475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BON","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"31141475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BOO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"31141475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BOO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
