6BKG
Human LigIV catalytic domain with bound DNA-adenylate intermediate in closed conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003909 | molecular_function | DNA ligase activity |
| A | 0003910 | molecular_function | DNA ligase (ATP) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006281 | biological_process | DNA repair |
| A | 0006310 | biological_process | DNA recombination |
| A | 0071897 | biological_process | DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 701 |
| Chain | Residue |
| A | VAL206 |
| A | ASN209 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 702 |
| Chain | Residue |
| A | TYR298 |
| A | ASP300 |
| A | GLN301 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 703 |
| Chain | Residue |
| A | HOH864 |
| D | DG5 |
| A | GLY509 |
| A | ILE581 |
| A | HOH801 |
| A | HOH808 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 704 |
| Chain | Residue |
| A | ARG383 |
| A | GLU514 |
| A | ASP517 |
| A | LEU518 |
| A | ASP586 |
| A | HOH855 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue AMP D 101 |
| Chain | Residue |
| A | GLU271 |
| A | THR272 |
| A | LYS273 |
| A | LEU274 |
| A | ARG278 |
| A | GLU331 |
| A | PHE367 |
| A | MET430 |
| A | LYS432 |
| A | LYS449 |
| A | LYS451 |
| D | DG2 |
| P | HOH103 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"N6-AMP-lysine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10135","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23523427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29980672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W1B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P18858","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23523427","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W5O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23523427","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W5O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
