6BJR
Crystal structure of prothrombin mutant S101C/A470C
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001530 | molecular_function | lipopolysaccharide binding |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005796 | cellular_component | Golgi lumen |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0007596 | biological_process | blood coagulation |
| A | 0008083 | molecular_function | growth factor activity |
| A | 0008201 | molecular_function | heparin binding |
| A | 0009611 | biological_process | response to wounding |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0010544 | biological_process | negative regulation of platelet activation |
| A | 0030168 | biological_process | platelet activation |
| A | 0030193 | biological_process | regulation of blood coagulation |
| A | 0030194 | biological_process | positive regulation of blood coagulation |
| A | 0030195 | biological_process | negative regulation of blood coagulation |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0032967 | biological_process | positive regulation of collagen biosynthetic process |
| A | 0042730 | biological_process | fibrinolysis |
| A | 0045861 | biological_process | negative regulation of proteolysis |
| A | 0046427 | biological_process | positive regulation of receptor signaling pathway via JAK-STAT |
| A | 0048018 | molecular_function | receptor ligand activity |
| A | 0048712 | biological_process | negative regulation of astrocyte differentiation |
| A | 0050878 | biological_process | regulation of body fluid levels |
| A | 0051281 | biological_process | positive regulation of release of sequestered calcium ion into cytosol |
| A | 0051480 | biological_process | regulation of cytosolic calcium ion concentration |
| A | 0051918 | biological_process | negative regulation of fibrinolysis |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| A | 0070053 | molecular_function | thrombospondin receptor activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070493 | biological_process | thrombin-activated receptor signaling pathway |
| A | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| A | 0072562 | cellular_component | blood microparticle |
| A | 1900016 | biological_process | negative regulation of cytokine production involved in inflammatory response |
| A | 1900182 | biological_process | positive regulation of protein localization to nucleus |
| A | 1900738 | biological_process | positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway |
| A | 2000379 | biological_process | positive regulation of reactive oxygen species metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00011 |
| Number of Residues | 26 |
| Details | GLA_1 Vitamin K-dependent carboxylation domain. EcvEEtCsyeeafEalesstatdv.FW |
| Chain | Residue | Details |
| A | CGU16-TRP41 |
| site_id | PS00021 |
| Number of Residues | 14 |
| Details | KRINGLE_1 Kringle domain signature. FCRNpdsstmgpWC |
| Chain | Residue | Details |
| A | PHE113-CYS126 | |
| A | PHE218-CYS231 |
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU359-CYS364 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
| Chain | Residue | Details |
| A | ASP519-VAL530 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | Domain: {"description":"Kringle 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00121","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by thrombin"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by factor Xa","evidences":[{"source":"PubMed","id":"34265300","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
