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6BH8

Crystal structure of ZMPSTE24 in complex with phosphoramidon

Functional Information from GO Data
ChainGOidnamespacecontents
A0003690molecular_functiondouble-stranded DNA binding
A0004175molecular_functionendopeptidase activity
A0004222molecular_functionmetalloendopeptidase activity
A0005515molecular_functionprotein binding
A0005635cellular_componentnuclear envelope
A0005637cellular_componentnuclear inner membrane
A0005789cellular_componentendoplasmic reticulum membrane
A0006508biological_processproteolysis
A0006998biological_processnuclear envelope organization
A0008233molecular_functionpeptidase activity
A0008235molecular_functionmetalloexopeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0031901cellular_componentearly endosome membrane
A0031902cellular_componentlate endosome membrane
A0032991cellular_componentprotein-containing complex
A0046872molecular_functionmetal ion binding
A0050688biological_processregulation of defense response to virus
A0051604biological_processprotein maturation
A0070062cellular_componentextracellular exosome
A0071586biological_processCAAX-box protein processing
B0003690molecular_functiondouble-stranded DNA binding
B0004175molecular_functionendopeptidase activity
B0004222molecular_functionmetalloendopeptidase activity
B0005515molecular_functionprotein binding
B0005635cellular_componentnuclear envelope
B0005637cellular_componentnuclear inner membrane
B0005789cellular_componentendoplasmic reticulum membrane
B0006508biological_processproteolysis
B0006998biological_processnuclear envelope organization
B0008233molecular_functionpeptidase activity
B0008235molecular_functionmetalloexopeptidase activity
B0008237molecular_functionmetallopeptidase activity
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0032991cellular_componentprotein-containing complex
B0046872molecular_functionmetal ion binding
B0050688biological_processregulation of defense response to virus
B0051604biological_processprotein maturation
B0070062cellular_componentextracellular exosome
B0071586biological_processCAAX-box protein processing
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 501
ChainResidue
AHIS335
AHIS339
AGLU415
ARDF502

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN B 501
ChainResidue
BHIS335
BHIS339
BGLU415
BRDF502

site_idAC3
Number of Residues2
Detailsbinding site for residue C8E B 503
ChainResidue
BTHR87
BGLU86

site_idAC4
Number of Residues13
Detailsbinding site for PHOSPHORAMIDON chain A
ChainResidue
ASER264
AASN265
AVAL332
AHIS335
AGLU336
AHIS339
AGLU415
ALEU435
ALEU438
AASN442
AHIS459
AARG465
AZN501

site_idAC5
Number of Residues13
Detailsbinding site for PHOSPHORAMIDON chain B
ChainResidue
BSER264
BASN265
BVAL332
BHIS335
BGLU336
BHIS339
BGLU415
BLEU435
BLEU438
BASN442
BHIS459
BARG465
BZN501

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues264
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues72
DetailsTopological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues91
DetailsTopological domain: {"description":"Nuclear","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsActive site: {"evidences":[{"source":"PubMed","id":"23539603","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23539603","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

249697

PDB entries from 2026-02-25

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