6BH8
Crystal structure of ZMPSTE24 in complex with phosphoramidon
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005637 | cellular_component | nuclear inner membrane |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0006998 | biological_process | nuclear envelope organization |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008235 | molecular_function | metalloexopeptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016020 | cellular_component | membrane |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0050688 | biological_process | regulation of defense response to virus |
| A | 0051604 | biological_process | protein maturation |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071586 | biological_process | CAAX-box protein processing |
| B | 0004175 | molecular_function | endopeptidase activity |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005637 | cellular_component | nuclear inner membrane |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006508 | biological_process | proteolysis |
| B | 0006998 | biological_process | nuclear envelope organization |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008235 | molecular_function | metalloexopeptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016020 | cellular_component | membrane |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0050688 | biological_process | regulation of defense response to virus |
| B | 0051604 | biological_process | protein maturation |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071586 | biological_process | CAAX-box protein processing |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | HIS335 |
| A | HIS339 |
| A | GLU415 |
| A | RDF502 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | HIS335 |
| B | HIS339 |
| B | GLU415 |
| B | RDF502 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue C8E B 503 |
| Chain | Residue |
| B | THR87 |
| B | GLU86 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for PHOSPHORAMIDON chain A |
| Chain | Residue |
| A | SER264 |
| A | ASN265 |
| A | VAL332 |
| A | HIS335 |
| A | GLU336 |
| A | HIS339 |
| A | GLU415 |
| A | LEU435 |
| A | LEU438 |
| A | ASN442 |
| A | HIS459 |
| A | ARG465 |
| A | ZN501 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for PHOSPHORAMIDON chain B |
| Chain | Residue |
| B | SER264 |
| B | ASN265 |
| B | VAL332 |
| B | HIS335 |
| B | GLU336 |
| B | HIS339 |
| B | GLU415 |
| B | LEU435 |
| B | LEU438 |
| B | ASN442 |
| B | HIS459 |
| B | ARG465 |
| B | ZN501 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 264 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 72 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 91 |
| Details | Topological domain: {"description":"Nuclear","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"23539603","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23539603","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
