6BGO

Singly PafE-capped 20S CP in Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004298	molecular_function	threonine-type endopeptidase activity
a	0005839	cellular_component	proteasome core complex
a	0010498	biological_process	proteasomal protein catabolic process
a	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0010498	biological_process	proteasomal protein catabolic process
A	0016787	molecular_function	hydrolase activity
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0019941	biological_process	modification-dependent protein catabolic process
A	0030682	biological_process	symbiont-mediated perturbation of host defenses
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005839	cellular_component	proteasome core complex
b	0010498	biological_process	proteasomal protein catabolic process
b	0051603	biological_process	proteolysis involved in protein catabolic process
c	0004298	molecular_function	threonine-type endopeptidase activity
c	0005839	cellular_component	proteasome core complex
c	0010498	biological_process	proteasomal protein catabolic process
c	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0004175	molecular_function	endopeptidase activity
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005839	cellular_component	proteasome core complex
C	0005886	cellular_component	plasma membrane
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0010498	biological_process	proteasomal protein catabolic process
C	0016787	molecular_function	hydrolase activity
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0019941	biological_process	modification-dependent protein catabolic process
C	0030682	biological_process	symbiont-mediated perturbation of host defenses
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
d	0000502	cellular_component	proteasome complex
d	0005886	cellular_component	plasma membrane
d	0009274	cellular_component	peptidoglycan-based cell wall
d	0022624	cellular_component	proteasome accessory complex
d	0051260	biological_process	protein homooligomerization
d	0061136	biological_process	regulation of proteasomal protein catabolic process
d	0070628	molecular_function	proteasome binding
d	1901800	biological_process	positive regulation of proteasomal protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0004175	molecular_function	endopeptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0005886	cellular_component	plasma membrane
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0010498	biological_process	proteasomal protein catabolic process
D	0016787	molecular_function	hydrolase activity
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0019941	biological_process	modification-dependent protein catabolic process
D	0030682	biological_process	symbiont-mediated perturbation of host defenses
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
e	0000502	cellular_component	proteasome complex
e	0005886	cellular_component	plasma membrane
e	0009274	cellular_component	peptidoglycan-based cell wall
e	0022624	cellular_component	proteasome accessory complex
e	0051260	biological_process	protein homooligomerization
e	0061136	biological_process	regulation of proteasomal protein catabolic process
e	0070628	molecular_function	proteasome binding
e	1901800	biological_process	positive regulation of proteasomal protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0004175	molecular_function	endopeptidase activity
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0005886	cellular_component	plasma membrane
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0010498	biological_process	proteasomal protein catabolic process
E	0016787	molecular_function	hydrolase activity
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0019941	biological_process	modification-dependent protein catabolic process
E	0030682	biological_process	symbiont-mediated perturbation of host defenses
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
f	0000502	cellular_component	proteasome complex
f	0005886	cellular_component	plasma membrane
f	0009274	cellular_component	peptidoglycan-based cell wall
f	0022624	cellular_component	proteasome accessory complex
f	0051260	biological_process	protein homooligomerization
f	0061136	biological_process	regulation of proteasomal protein catabolic process
f	0070628	molecular_function	proteasome binding
f	1901800	biological_process	positive regulation of proteasomal protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0005886	cellular_component	plasma membrane
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0010498	biological_process	proteasomal protein catabolic process
F	0016787	molecular_function	hydrolase activity
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0019941	biological_process	modification-dependent protein catabolic process
F	0030682	biological_process	symbiont-mediated perturbation of host defenses
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
g	0000502	cellular_component	proteasome complex
g	0005886	cellular_component	plasma membrane
g	0009274	cellular_component	peptidoglycan-based cell wall
g	0022624	cellular_component	proteasome accessory complex
g	0051260	biological_process	protein homooligomerization
g	0061136	biological_process	regulation of proteasomal protein catabolic process
g	0070628	molecular_function	proteasome binding
g	1901800	biological_process	positive regulation of proteasomal protein catabolic process
G	0000502	cellular_component	proteasome complex
G	0004175	molecular_function	endopeptidase activity
G	0004298	molecular_function	threonine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005839	cellular_component	proteasome core complex
G	0005886	cellular_component	plasma membrane
G	0009274	cellular_component	peptidoglycan-based cell wall
G	0010498	biological_process	proteasomal protein catabolic process
G	0016787	molecular_function	hydrolase activity
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0019941	biological_process	modification-dependent protein catabolic process
G	0030682	biological_process	symbiont-mediated perturbation of host defenses
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0051603	biological_process	proteolysis involved in protein catabolic process
h	0000502	cellular_component	proteasome complex
h	0005886	cellular_component	plasma membrane
h	0009274	cellular_component	peptidoglycan-based cell wall
h	0022624	cellular_component	proteasome accessory complex
h	0051260	biological_process	protein homooligomerization
h	0061136	biological_process	regulation of proteasomal protein catabolic process
h	0070628	molecular_function	proteasome binding
h	1901800	biological_process	positive regulation of proteasomal protein catabolic process
H	0000502	cellular_component	proteasome complex
H	0004175	molecular_function	endopeptidase activity
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005839	cellular_component	proteasome core complex
H	0005886	cellular_component	plasma membrane
H	0009274	cellular_component	peptidoglycan-based cell wall
H	0010498	biological_process	proteasomal protein catabolic process
H	0016787	molecular_function	hydrolase activity
H	0019773	cellular_component	proteasome core complex, alpha-subunit complex
H	0019941	biological_process	modification-dependent protein catabolic process
H	0030682	biological_process	symbiont-mediated perturbation of host defenses
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0051603	biological_process	proteolysis involved in protein catabolic process
i	0000502	cellular_component	proteasome complex
i	0005886	cellular_component	plasma membrane
i	0009274	cellular_component	peptidoglycan-based cell wall
i	0022624	cellular_component	proteasome accessory complex
i	0051260	biological_process	protein homooligomerization
i	0061136	biological_process	regulation of proteasomal protein catabolic process
i	0070628	molecular_function	proteasome binding
i	1901800	biological_process	positive regulation of proteasomal protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0004175	molecular_function	endopeptidase activity
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005839	cellular_component	proteasome core complex
I	0005886	cellular_component	plasma membrane
I	0009274	cellular_component	peptidoglycan-based cell wall
I	0010498	biological_process	proteasomal protein catabolic process
I	0016787	molecular_function	hydrolase activity
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0019941	biological_process	modification-dependent protein catabolic process
I	0030682	biological_process	symbiont-mediated perturbation of host defenses
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
j	0000502	cellular_component	proteasome complex
j	0005886	cellular_component	plasma membrane
j	0009274	cellular_component	peptidoglycan-based cell wall
j	0022624	cellular_component	proteasome accessory complex
j	0051260	biological_process	protein homooligomerization
j	0061136	biological_process	regulation of proteasomal protein catabolic process
j	0070628	molecular_function	proteasome binding
j	1901800	biological_process	positive regulation of proteasomal protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0004175	molecular_function	endopeptidase activity
J	0004298	molecular_function	threonine-type endopeptidase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005839	cellular_component	proteasome core complex
J	0005886	cellular_component	plasma membrane
J	0009274	cellular_component	peptidoglycan-based cell wall
J	0010498	biological_process	proteasomal protein catabolic process
J	0016787	molecular_function	hydrolase activity
J	0019773	cellular_component	proteasome core complex, alpha-subunit complex
J	0019941	biological_process	modification-dependent protein catabolic process
J	0030682	biological_process	symbiont-mediated perturbation of host defenses
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0004175	molecular_function	endopeptidase activity
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005839	cellular_component	proteasome core complex
K	0005886	cellular_component	plasma membrane
K	0009274	cellular_component	peptidoglycan-based cell wall
K	0010498	biological_process	proteasomal protein catabolic process
K	0016787	molecular_function	hydrolase activity
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0019941	biological_process	modification-dependent protein catabolic process
K	0030682	biological_process	symbiont-mediated perturbation of host defenses
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0000502	cellular_component	proteasome complex
L	0004175	molecular_function	endopeptidase activity
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005839	cellular_component	proteasome core complex
L	0005886	cellular_component	plasma membrane
L	0009274	cellular_component	peptidoglycan-based cell wall
L	0010498	biological_process	proteasomal protein catabolic process
L	0016787	molecular_function	hydrolase activity
L	0019773	cellular_component	proteasome core complex, alpha-subunit complex
L	0019941	biological_process	modification-dependent protein catabolic process
L	0030682	biological_process	symbiont-mediated perturbation of host defenses
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0004175	molecular_function	endopeptidase activity
M	0004298	molecular_function	threonine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0005886	cellular_component	plasma membrane
M	0009274	cellular_component	peptidoglycan-based cell wall
M	0010498	biological_process	proteasomal protein catabolic process
M	0016787	molecular_function	hydrolase activity
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0019941	biological_process	modification-dependent protein catabolic process
M	0030682	biological_process	symbiont-mediated perturbation of host defenses
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0000502	cellular_component	proteasome complex
N	0004175	molecular_function	endopeptidase activity
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005839	cellular_component	proteasome core complex
N	0005886	cellular_component	plasma membrane
N	0009274	cellular_component	peptidoglycan-based cell wall
N	0010498	biological_process	proteasomal protein catabolic process
N	0016787	molecular_function	hydrolase activity
N	0019773	cellular_component	proteasome core complex, alpha-subunit complex
N	0019941	biological_process	modification-dependent protein catabolic process
N	0030682	biological_process	symbiont-mediated perturbation of host defenses
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0004175	molecular_function	endopeptidase activity
O	0004298	molecular_function	threonine-type endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005839	cellular_component	proteasome core complex
O	0005886	cellular_component	plasma membrane
O	0009274	cellular_component	peptidoglycan-based cell wall
O	0010498	biological_process	proteasomal protein catabolic process
O	0016787	molecular_function	hydrolase activity
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0019941	biological_process	modification-dependent protein catabolic process
O	0030682	biological_process	symbiont-mediated perturbation of host defenses
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
P	0004298	molecular_function	threonine-type endopeptidase activity
P	0005839	cellular_component	proteasome core complex
P	0010498	biological_process	proteasomal protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0004298	molecular_function	threonine-type endopeptidase activity
Q	0005839	cellular_component	proteasome core complex
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
R	0004298	molecular_function	threonine-type endopeptidase activity
R	0005839	cellular_component	proteasome core complex
R	0010498	biological_process	proteasomal protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0004298	molecular_function	threonine-type endopeptidase activity
S	0005839	cellular_component	proteasome core complex
S	0010498	biological_process	proteasomal protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
T	0004298	molecular_function	threonine-type endopeptidase activity
T	0005839	cellular_component	proteasome core complex
T	0010498	biological_process	proteasomal protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
U	0004298	molecular_function	threonine-type endopeptidase activity
U	0005839	cellular_component	proteasome core complex
U	0010498	biological_process	proteasomal protein catabolic process
U	0051603	biological_process	proteolysis involved in protein catabolic process
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0010498	biological_process	proteasomal protein catabolic process
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005839	cellular_component	proteasome core complex
W	0010498	biological_process	proteasomal protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0004298	molecular_function	threonine-type endopeptidase activity
X	0005839	cellular_component	proteasome core complex
X	0010498	biological_process	proteasomal protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005839	cellular_component	proteasome core complex
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005839	cellular_component	proteasome core complex
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:20711362

Chain	Residue	Details
P	THR301
Y	THR301
Z	THR301
a	THR301
b	THR301
c	THR301
Q	THR301
R	THR301
S	THR301
T	THR301
U	THR301
V	THR301
W	THR301
X	THR301

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site_id	SWS_FT_FI2
Number of Residues	14
Details	SITE: Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986

Chain	Residue	Details
P	THR301
Y	THR301
Z	THR301
a	THR301
b	THR301
c	THR301
F	THR202
G	THR84
G	THR178
G	THR202
H	THR84
Q	THR301
H	THR178
H	THR202
I	THR84
I	THR178
I	THR202
J	THR84
J	THR178
J	THR202
K	THR84
K	THR178
R	THR301
K	THR202
L	THR84
L	THR178
L	THR202
M	THR84
M	THR178
M	THR202
N	THR84
N	THR178
N	THR202
S	THR301
O	THR84
O	THR178
O	THR202
T	THR301
U	THR301
V	THR301
W	THR301
X	THR301

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